FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Rab6, TBC1D5
FlyBase ID
FBig0000103668
Interaction Network
Interactions Browser links
Rab6 network
TBC1D5 network
Reported Interactions
FBrf0226902-30.PD.WB
Reference
Gillingham et al., 2014
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
Rab6 

Rab6

bait

GST tag

Rab6 
Rab6 
TBC1D5 

TBC1D5

prey

GFP tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Rab6 
GTPase domain
mutation increasing interaction
aa 71

Q71L, GTP-locked

Rab6 
GTPase domain
mutation disrupting interaction
aa 26

T26N, GDP-locked

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Gillingham et al., 2014)

CG8449 specifically binds the GTP-bound state of Rab6, and more strongly to the GTP-bound state of Rab18 (but not the GDP-locked state).

(Gillingham et al., 2014)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (1)