FlyBase Gene Report: Dmel\CadN2

General Information

Symbol

Dmel\CadN2

Species

D. melanogaster

Name

Cadherin-N2

Annotation Symbol

CG42829

Feature Type

protein_coding_gene

FlyBase ID

FBgn0262018

Gene Model Status

Current

Stock Availability

11 publicly available

Gene Summary

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells (By similarity). (UniProt, Q9VJB6)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

NCad2, N-cadherin2, CT23007

Key Links

Genomic Location

Cytogenetic map

36D3-36E1

Sequence location

2L:17,786,971..17,875,247 [-]

Recombination map

2-53

RefSeq locus

NT_033779 REGION:17786971..17875247

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (17 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables beta-catenin binding

inferred from biological aspect of ancestor with PANTHER:PTN008601603

(GO Reference Genome Project, 2011-)

enables cadherin binding

inferred from biological aspect of ancestor with PANTHER:PTN008601603

(GO Reference Genome Project, 2011-)

enables calcium ion binding

inferred from electronic annotation with InterPro:IPR000233, InterPro:IPR001881, InterPro:IPR002126, InterPro:IPR015919

(InterPro Project Members, 2004-)

inferred from sequence model

(Hill et al., 2001)

Biological Process (11 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in axon extension involved in axon guidance

inferred from mutant phenotype

(Prakash et al., 2005)

involved_in ommatidial rotation

inferred from mutant phenotype

(Mirkovic and Mlodzik, 2006)

involved_in R7 cell development

inferred from mutant phenotype

(Yonekura et al., 2007)

involved_in R8 cell development

inferred from mutant phenotype

(Yonekura et al., 2007)

Terms Based on Predictions or Assertions (7 terms)

CV Term

Evidence

References

involved_in calcium-dependent cell-cell adhesion

inferred from sequence or structural similarity

(Hynes and Zhao, 2000)

involved_in cell adhesion

inferred from electronic annotation with InterPro:IPR020894

(InterPro Project Members, 2004-)

involved_in cell migration

inferred from biological aspect of ancestor with PANTHER:PTN008601603

(GO Reference Genome Project, 2011-)

involved_in cell-cell adhesion mediated by cadherin

inferred from sequence model

(Hill et al., 2001)

involved_in cell-cell adhesion

inferred from electronic annotation with InterPro:IPR039808

(InterPro Project Members, 2004-)

involved_in homophilic cell-cell adhesion

inferred from electronic annotation with InterPro:IPR000233, InterPro:IPR002126

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity

(Hynes and Zhao, 2000)

involved_in neuron projection development

inferred from biological aspect of ancestor with PANTHER:PTN004649584

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

part_of catenin complex

inferred from biological aspect of ancestor with PANTHER:PTN008601603

(GO Reference Genome Project, 2011-)

located_in membrane

inferred from electronic annotation with InterPro:IPR002126, InterPro:IPR015919

(InterPro Project Members, 2004-)

located_in plasma membrane

inferred from electronic annotation with InterPro:IPR020894

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity

(Hynes and Zhao, 2000)

Gene Group (FlyBase)

CADHERINS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

CADHERINS -: The cadherin superfamily represent a diverse group of transmembrane receptors which mediate cell-cell adhesion. Cadherins are defined by the presence of cadherin domains, typically organised in tandem repeats, which mediate calcium-dependent homophilic interactions between cadherin molecules. (Adapted from FBrf0146675).

Protein Function (UniProtKB)

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells (By similarity).

(UniProt, Q9VJB6)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CadN2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VJB6)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Is a partial duplication of the neighboring CadN gene. CadN2 is very similar to the carboxy-terminal half of CadN. CadN2 may be a pseudogene (FBrf0134734).

Gene model reviewed during 5.40

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.50

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CadN2-RC

FBtr0303836

NM_001042903

7220

1799

CadN2-RD

FBtr0308770

NM_136011

7914

1799

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

CadN2-PC

FBpp0292843

200.5

1799

5.01

FBpp0300935

200.5

1799

5.01

Q9VJB6

NP_609855

AAF53636

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1799 aa isoforms: CadN2-PC, CadN2-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Domain

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

(UniProt, Q9VJB6)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VJB6

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CadN2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CadN2_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.25

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CadN2 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CadN2

View exonic expression by tissue for Dmel\CadN2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35071/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0262018

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0262018

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 12 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CadN2

Transgenic constructs containing regulatory region of CadN2

Aberrations (Deficiencies and Duplications) ( 5 )

Inferred from experimentation ( 5 )

Gene disrupted in

Df(2L)CadN^Δ4

(Prakash et al., 2005)

Df(2L)CadN^Δ14

(Prakash et al., 2005)

Df(2L)Δ6

(Prakash et al., 2005)

Df(2L)Δ12

(Prakash et al., 2005)

Df(2L)E48

(Schäfer et al., 2014)

Inferred from location ( 2 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die, with Scer\GAL4^pnr-MD237

CadN2^GD2658

viable

CadN2^Δ7

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CadN2^GD14316

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

CadN2^GD14316

viable, with Scer\GAL4^tin.CΔ4

Other Phenotypes

Allele

abnormal locomotor behavior | adult stage

CadN2^MB08260

some die during pupal stage, with Scer\GAL4^pnr-MD237

CadN2^GD2658

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (63)

Hsap\CDH1

3 of 14

Yes

Hsap\CDH2

3 of 14

Yes

Hsap\CDH4

3 of 14

Yes

Hsap\CDH5

3 of 14

Yes

Hsap\CDH6

3 of 14

Yes

Hsap\CDH7

3 of 14

Yes

Hsap\CDH8

3 of 14

Yes

Hsap\CDH9

3 of 14

Yes

Hsap\CDH10

3 of 14

Yes

Hsap\CDH11

3 of 14

Yes

Hsap\CDH12

3 of 14

Yes

Hsap\CDH15

3 of 14

Yes

Hsap\CDH18

3 of 14

Yes

Hsap\CDH19

3 of 14

Yes

Hsap\CDH20

3 of 14

Yes

Hsap\CDH22

3 of 14

Yes

Hsap\CDH24

3 of 14

Yes

Hsap\DCHS1

3 of 14

Yes

Hsap\FAT4

3 of 14

Yes

Hsap\CDH3

2 of 14

Yes

Hsap\CDH13

2 of 14

Yes

Hsap\CDH17

2 of 14

Yes

Hsap\CDH23

2 of 14

Hsap\CDH26

2 of 14

Yes

Hsap\DCHS2

2 of 14

Hsap\DSC1

2 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\DSC3

1 of 14

Yes

Hsap\DSG1

1 of 14

Yes

Hsap\DSG2

1 of 14

Yes

Hsap\DSG3

1 of 14

Yes

Hsap\DSG4

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\PCDHGA9

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (42)

Rnor\Cdh1

3 of 14

Yes

Rnor\Cdh2

3 of 14

Yes

Rnor\Cdh6

3 of 14

Yes

Rnor\Cdh7

3 of 14

Yes

Rnor\Cdh8

3 of 14

Yes

Rnor\Cdh9

3 of 14

Yes

Rnor\Cdh10

3 of 14

Yes

Rnor\Cdh11

3 of 14

Yes

Rnor\Cdh12

3 of 14

Yes

Rnor\Cdh15

3 of 14

Yes

Rnor\Cdh18

3 of 14

Yes

Rnor\Cdh19

3 of 14

Yes

Rnor\Cdh20

3 of 14

Yes

Rnor\Cdh22

3 of 14

Yes

Rnor\Cdh24

3 of 14

Yes

Rnor\Dchs1

3 of 14

Yes

Rnor\Cdh5

2 of 14

Yes

Rnor\Cdh17

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Cdh13

1 of 14

Yes

Rnor\Cdh23

1 of 14

Rnor\Cdh26

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (47)

Mmus\Cdh1

3 of 14

Yes

Mmus\Cdh2

3 of 14

Yes

Mmus\Cdh4

3 of 14

Yes

Mmus\Cdh6

3 of 14

Yes

Mmus\Cdh7

3 of 14

Yes

Mmus\Cdh8

3 of 14

Yes

Mmus\Cdh9

3 of 14

Yes

Mmus\Cdh10

3 of 14

Yes

Mmus\Cdh11

3 of 14

Yes

Mmus\Cdh12

3 of 14

Yes

Mmus\Cdh18

3 of 14

Yes

Mmus\Cdh19

3 of 14

Yes

Mmus\Cdh20

3 of 14

Yes

Mmus\Cdh22

3 of 14

Yes

Mmus\Cdh24

3 of 14

Yes

Mmus\Dchs1

3 of 14

Yes

Mmus\Fat4

3 of 14

Yes

Mmus\Cdh5

2 of 14

Yes

Mmus\Cdh15

2 of 14

Yes

Mmus\Cdh17

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Cdh13

1 of 14

Yes

Mmus\Cdh23

1 of 14

Mmus\Cdh26

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (40)

Xtro\LOC100493382

8 of 13

Yes

Xtro\LOC100494953

6 of 13

Yes

Xtro\cdh3

3 of 13

Yes

Xtro\cdh5

3 of 13

Yes

Xtro\cdh7

3 of 13

Yes

Xtro\cdh8

3 of 13

Yes

Xtro\cdh9

3 of 13

Yes

Xtro\cdh10

3 of 13

Yes

Xtro\cdh12

3 of 13

Yes

Xtro\cdh18

3 of 13

Yes

Xtro\cdh2

2 of 13

Yes

Xtro\cdh6

2 of 13

Yes

Xtro\cdh11

2 of 13

Yes

Xtro\cdh13

2 of 13

Yes

Xtro\cdh15

2 of 13

Yes

Xtro\cdh16

2 of 13

Yes

Xtro\cdh19

2 of 13

Yes

Xtro\cdh20

2 of 13

Yes

Xtro\agrn

1 of 13

Xtro\ccdc88a

1 of 13

Xtro\cdh1

1 of 13

Yes

Xtro\cdh4

1 of 13

Yes

Xtro\cdh17

1 of 13

Yes

Xtro\cdh22

1 of 13

Yes

Xtro\cdh24

1 of 13

Yes

Xtro\cdh26

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (54)

Drer\si:ch211-186j3.6

9 of 14

Yes

Drer\si:dkey-22o22.2

9 of 14

Yes

Drer\cdh4

3 of 14

Yes

Drer\cdh6

3 of 14

Yes

Drer\cdh7a

3 of 14

Yes

Drer\cdh10a

3 of 14

Yes

Drer\cdh11

3 of 14

Yes

Drer\dchs1a

3 of 14

Drer\LOC101883589

3 of 14

Drer\LOC101886358

3 of 14

Yes

Drer\cdh1

2 of 14

Yes

Drer\cdh2

2 of 14

Yes

Drer\cdh12a

2 of 14

Yes

Drer\cdh15

2 of 14

Yes

Drer\cdh18a

2 of 14

Yes

Drer\cdh23

2 of 14

Drer\cdh31

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Drer\agrn

1 of 14

Drer\cdh5

1 of 14

Yes

Drer\cdh13

1 of 14

Yes

Drer\cdh16

1 of 14

Yes

Drer\cdh17

1 of 14

Yes

Drer\cdh19

1 of 14

Yes

Drer\cdh26.1

1 of 14

Yes

Drer\cdh26.2

1 of 14

Yes

Drer\cdh27

1 of 14

Yes

Drer\cdh28

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:dkey-30c15.12

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (20)

Cele\hmr-1

9 of 14

Yes

Cele\cdh-4

3 of 14

Cele\cdh-1

2 of 14

Cele\Y52B11A.11

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (42)

Agam\AgaP_AGAP009716

5 of 12

Yes

Agam\AgaP_AGAP009717

5 of 12

Yes

Agam\AgaP_AGAP009723

5 of 12

Yes

Agam\AgaP_AGAP009711

4 of 12

Yes

Agam\AgaP_AGAP009726

4 of 12

Agam\AgaP_AGAP009715

3 of 12

Agam\AgaP_AGAP009722

3 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

Yes

Agam\AgaP_AGAP009721

2 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CadN2. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (16)

CadN

9 of 13

shg

4 of 13

3 of 13

2 of 13

kug

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

eys

1 of 13

Lrp4

1 of 13

Sfp53D

1 of 13

SP2353

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 14 )

Human Ortholog

Disease

Evidence

References

DCHS1; dachsous cadherin-related 1

model of mitral valve prolapse

IEA

(FlyBase, 2019-)

model of Van Maldergem syndrome 1

IEA

(FlyBase, 2019-)

FAT4; FAT atypical cadherin 4

model of Hennekam syndrome

IEA

(FlyBase, 2019-)

model of Van Maldergem syndrome 2

IEA

(FlyBase, 2019-)

CDH11; cadherin 11

model of Elsahy-Waters syndrome

IEA

(FlyBase, 2019-)

model of Teebi hypertelorism syndrome 2

IEA

(FlyBase, 2019-)

CDH2; cadherin 2

model of agenesis of corpus callosum, cardiac, ocular, and genital syndrome

IEA

(FlyBase, 2019-)

model of arrhythmogenic right ventricular dysplasia 14

IEA

(FlyBase, 2019-)

CDH15; cadherin 15

model of autosomal dominant intellectual developmental disorder 3

IEA

(FlyBase, 2019-)

CDH1; cadherin 1

model of endometrial cancer

IEA

(FlyBase, 2019-)

model of breast cancer

IEA

(FlyBase, 2019-)

model of ovarian cancer

IEA

(FlyBase, 2019-)

model of blepharocheilodontic syndrome 1

IEA

(FlyBase, 2019-)

model of hereditary diffuse gastric cancer

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL DOMINANT 3; MRD3

autosomal dominant intellectual developmental disorder 3

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

DCHS1; dachsous cadherin-related 1

3 of 14

603057

FAT4; FAT atypical cadherin 4

3 of 14

FAT ATYPICAL CADHERIN 4; FAT4

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

kon

suppressible

CadN2

(Harrison et al., 2021)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0262018

MIST (protein-protein) - An integrated Molecular Interaction Database

35071

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

(FlyBase Genome Annotators, 2010)

protein_coding_gene

(FlyBase Genome Annotators, 2010)

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-53

Cytogenetic map

36D3-36E1

Sequence location

2L:17,786,971..17,875,247 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

36D3-36E1

Limits computationally determined from genome sequence between P{lacW}Aac11^k06710 and P{EP}CG10413^EP2164;

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-53

(FlyBase, 2016)

2-52.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

27508

y¹ v¹; P{TRiP.JF02658}attP2

40889

y¹ v¹; P{TRiP.HMS02137}attP40/CyO

41052

y¹ w^*; Mi{MIC}CadN2^MI05129

37249

y¹ w^*; Mi{MIC}CadN2^MI04133/SM6a

81201

y¹ w^*; TI{CRIMIC.TG4.1}CadN2^{CR01165-TG4.1}/SM6a

NIG-Fly

M2L-0813

y¹ w¹¹¹⁸; CadN2^SK1 P{neoFRT}40A/CyO-Tb

M2L-0814

y¹ w¹¹¹⁸; CadN2^SK4 P{neoFRT}40A/CyO-Tb

2LG-0644

y² VhaAC39-1^cho-1 v¹; P{U6-CadN2.NIG.sgRNA}attP40/CyO

VDRC

v101659

P{KK105358}VIE-260B

v36166

w¹¹¹⁸; P{GD14316}v36166

v342584

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD02347}attP40/CyO-GFP

Genomic Clones (66)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (3)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0262018

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

The CadN2 protein, along with CadN, acts to restrict ommatidial rotation.

(Mirkovic and Mlodzik, 2006)

CadN2 is required in both individual photoreceptors and their target neurons for photoreceptor axon extension. CadN and CadN2 appear to function redundantly in this process.

(Prakash et al., 2005)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Relationship to Other Genes

Source for database merge of

Additional comments

Annotation CG7527 split into CG42829 (which corresponds to CadN2) and CG42830 in release 5.30 of the genome annotation.

(FlyBase Genome Annotators, 2010)

Nomenclature History

Source for database identify of

Source for identity of: DN-Cad2 CG7527

(Hynes and Zhao, 2000)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (18)

Reported As

Symbol Synonym

CG42829

(National Institute of Genetics Fly Stocks, 2022-, Ni et al., 2010.12.1)

CG7527

(Keleman et al., 2009.8.5, Perkins et al., 2009, Hill et al., 2001)

CT23007

(Hynes and Zhao, 2000, Hynes and Zhao, 2000)

DN-Cad2

DN-cad2

(Mirkovic and Mlodzik, 2006)

DN-like

(Hynes and Zhao, 2000)

DNcad2

(Tepass and Harris, 2007)

DmNCad2

(Robertson, 2001.10.17)

N-Cad2

(Caldwell and Eberl, 2005)

NCad2

(Tajiri et al., 2007, Caldwell and Eberl, 2006, Yonekura et al., 2004)

Ncad2

(Biersmith et al., 2011)

cadN2

(Harrison et al., 2021, Mirkovic and Mlodzik, 2006, Read et al., 2005)

Name Synonyms

CadN2

(Fung et al., 2008)

Cadherin N2r

(Girard et al., 2006)

Cadherin-N2

DN-cadh-like

(Hynes and Zhao, 2000)

DN-cadherin

(Mirkovic and Mlodzik, 2006)

N-cadherin2

(Biersmith et al., 2011, Prakash et al., 2005)

Secondary FlyBase IDs

FBgn0032655
FBgn0262011

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 46 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35071

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VJB6

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VJB6

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VJB6

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35071/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0262018

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0262018

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG42829

MARRVEL_MODEL - MARRVEL (model organism gene)

35071

Linkouts

Cell Signaling Technology - Commercial vendor for primary antibodies and antibody conjugates.

4068

DroID - A comprehensive database of gene and protein interactions.

FBgn0262018

DRSC - Results frm RNAi screens

FBgn0262018

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CadN2_1

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0262018

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0262018

MIST (protein-protein) - An integrated Molecular Interaction Database

35071

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (80)

The following external sites may use different assemblies or annotations than FlyBase.

-0.25

Report Sections