FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\kon
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General Information
Symbol
Dmel\kon
Species
D. melanogaster
Name
kon-tiki
Annotation Symbol
CG10275
Feature Type
protein_coding_gene
FlyBase ID
FBgn0032683
Gene Model Status
Current
Stock Availability
14 publicly available
Gene Summary
kon-tiki (kon) (also known as perdido) encodes a single transmembrane protein required to initiate muscle-tendon attachment in a group of embryonic and adult body muscles. kon mutants are embryonic lethal with rounded ventral longitudinal muscles. It concentrates at muscle attachment sites and genetically interacts with integrins. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

perd, perdido

Key Links
Genomic Location
Cytogenetic map
36F5-36F6
Sequence location
Recombination map
2-53
RefSeq locus
NT_033779 REGION:18487747..18503978
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (13 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with FLYBASE:Grip; FB:FBgn0029830
(Estrada et al., 2007)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (7 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in muscle organ development
inferred from mutant phenotype
(Schnorrer et al., 2007)
involved_in myofibril assembly
inferred from mutant phenotype
(Pérez-Moreno et al., 2014)
involved_in positive regulation of filopodium assembly
inferred from mutant phenotype
(Schnorrer et al., 2007)
involved_in sarcomere organization
inferred from mutant phenotype
(Pérez-Moreno et al., 2014)
involved_in somatic muscle attachment to chitin-based cuticle
inferred from mutant phenotype
(Estrada et al., 2007)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in nervous system development
inferred from biological aspect of ancestor with PANTHER:PTN000804946
(GO Reference Genome Project, 2011-)
involved_in signal transduction
inferred from biological aspect of ancestor with PANTHER:PTN002309037
(GO Reference Genome Project, 2011-)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
located_in cell tip
inferred from direct assay
(Schnorrer et al., 2007)
located_in costamere
inferred from direct assay
(Pérez-Moreno et al., 2014)
located_in muscle tendon junction
inferred from direct assay
(Pérez-Moreno et al., 2014)
located_in Z disc
inferred from direct assay
(Pérez-Moreno et al., 2014)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN002309037
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
kon-tiki (kon) (also known as perdido) encodes a single transmembrane protein required to initiate muscle-tendon attachment in a group of embryonic and adult body muscles. kon mutants are embryonic lethal with rounded ventral longitudinal muscles. It concentrates at muscle attachment sites and genetically interacts with integrins. [Date last reviewed: 2019-03-14]
Summary (Interactive Fly)

conserved multi-domain transmembrane receptor required cell autonomously for myotubes to recognize their tendon cell targets - signals through the intracellular adaptor Grip in a conserved molecular pathway

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\kon for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VJ82)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
kon-RB
FBtr0300341
NM_136037
8276
2381
kon-RC
FBtr0332322
NM_001273610
8254
2381
kon-RD
FBtr0332323
NM_001273611
7530
2381
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
kon-PB
FBpp0289570
270.7
2381
5.57
Q9VJ82
NP_609881
AAF53672
kon-PC
FBpp0304600
270.7
2381
5.57
Q9VJ82
NP_001260539
AGB93074
kon-PD
FBpp0304601
270.7
2381
5.57
Q9VJ82
NP_001260540
AGB93075
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

2381 aa isoforms: kon-PB, kon-PC, kon-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\kon using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.20

Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
larval neuropil glial cell
(Losada-Perez et al., 2016)
pupal stage
precursor of adult central brain neuropil glia
(Losada-Perez et al., 2016)
Additional Descriptive Data

Early, kon is distributed along Fas2+ axonal fascicles. Later, kon colocalizes with ScerGAL4alrm.PD expression within and around the neuropil. In pupae, kon is prominent within the neuropil and also colocalizes with Gs2 in cell bodies wrapping the neuropil.

(Losada-Perez et al., 2016)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cell tip
inferred from direct assay
(Schnorrer et al., 2007)
located_in costamere
inferred from direct assay
(Pérez-Moreno et al., 2014)
located_in muscle tendon junction
inferred from direct assay
(Pérez-Moreno et al., 2014)
located_in Z disc
inferred from direct assay
(Pérez-Moreno et al., 2014)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\kon in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 27 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of kon
Transgenic constructs containing regulatory region of kon
Aberrations (Deficiencies and Duplications) ( 9 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4insc-Mz1407
lethal (with Df(2L)M36F-S5)
lethal (with konA04)
lethal (with konA49)
lethal (with konC25)
lethal (with konC41)
lethal (with konC452)
lethal (with konC1115)
lethal (with konC1139)
lethal (with konC2263)
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
viable (with Df(2L)BSC149)
Other Phenotypes
Allele
abnormal eclosion, with Scer\GAL4Mef2.PR
abnormal neuroanatomy | larval stage, with Scer\GAL4insc-Mz1407
decreased size | pupal stage, with Scer\GAL4Mef2.PR
increased cell number | larval stage, with Scer\GAL4repo.PU
increased size | larval stage, with Scer\GAL4elav.PU
increased size | larval stage, with Scer\GAL4repo.PU
some die during pupal stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4Bx-MS1096
Phenotype manifest in
Allele
abdominal dorsal muscle cell, with Scer\GAL41151
abdominal dorsal muscle cell, with Scer\GAL4Mef2.PR
dorsal transverse muscle | embryonic stage
embryonic somatic muscle cell, with Scer\GAL4Mef2.PR
epithelium, with Scer\GAL4NP1624
exuvial fluid | pupal stage, with Scer\GAL4Mef2.PR
female germline cyst, with Scer\GAL4NP1624
filopodium | ectopic, with Scer\GAL4Mef2.PR
ganglion mother cell | larval stage, with Scer\GAL4insc-Mz1407
hypodermal muscle of A1-7 | embryonic stage
hypodermal muscle of A1-7 | embryonic stage (with kon2986)
hypodermal muscle of A1-7 | embryonic stage (with konsj11)
hypodermal muscle of A1-7 | embryonic stage (with konsj204)
hypodermal muscle of A1-7 | embryonic stage (with konsj525)
H zone, with Scer\GAL4Mef2.PR
indirect flight muscle cell | pupal stage, with Scer\GAL4Mef2.PR
larval glial cell | increased number | larval stage, with Scer\GAL4repo.PU
larval neuroblast | larval stage, with Scer\GAL4insc-Mz1407
larval somatic muscle cell
larval ventral nerve cord, with Scer\GAL4elav.PU
larval ventral nerve cord, with Scer\GAL4repo.PU
muscle cell of A1-7 ventral longitudinal muscle 1
muscle cell of A1-7 ventral longitudinal muscle 1 (with Df(2L)TW137)
muscle cell of A1-7 ventral longitudinal muscle 1 (with konC25)
muscle cell of A1-7 ventral longitudinal muscle 1 (with konC41)
muscle cell of A1-7 ventral longitudinal muscle 1 (with konC452)
muscle cell of A1-7 ventral longitudinal muscle 1 (with konC1139)
muscle cell of A1-7 ventral longitudinal muscle 2 (with konC41)
muscle cell of A1-7 ventral longitudinal muscle 2 (with konC452)
muscle cell of A1-7 ventral longitudinal muscle 3 (with konC41)
muscle cell of A1-7 ventral longitudinal muscle 3 (with konC452)
muscle cell of A1-7 ventral longitudinal muscle 4 (with konC41)
muscle cell of A1-7 ventral longitudinal muscle 4 (with konC452)
myotube | pupal stage, with Scer\GAL4Mef2.PR
sarcomere, with Scer\GAL4Mef2.PR
segment border muscle cell
temporary eclosion muscle cell, with Scer\GAL4Mef2.PR
ventral acute muscle 2 | embryonic stage
ventral acute muscle 2 | embryonic stage (with kon2986)
ventral acute muscle 2 | embryonic stage (with konsj11)
ventral acute muscle 2 | embryonic stage (with konsj204)
ventral acute muscle 2 | embryonic stage (with konsj525)
ventral acute muscle 3 | embryonic stage
ventral longitudinal muscle cell
wing, with Scer\GAL4Bx-MS1096
Z disc, with Scer\GAL4Mef2.PR
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (19)
Hsap\CSPG4
12 of 14
Yes
Yes
Hsap\FRAS1
3 of 14
No
Yes
Hsap\FREM2
3 of 14
No
Yes
Hsap\FREM3
3 of 14
No
Yes
Hsap\FREM1
2 of 14
No
Yes
Hsap\CNTNAP1
1 of 14
No
No
1  
Hsap\CNTNAP2
1 of 14
No
No
Hsap\CNTNAP3B
1 of 14
No
No
Hsap\CNTNAP3C
1 of 14
No
No
Hsap\CNTNAP3
1 of 14
No
No
Hsap\CNTNAP4
1 of 14
No
No
Hsap\CNTNAP5
1 of 14
No
No
Hsap\EGFLAM
1 of 14
No
No
1  
Hsap\LAMA1
1 of 14
No
No
Hsap\LAMA3
1 of 14
No
No
Hsap\NRXN1
1 of 14
No
No
5  
Hsap\NRXN2
1 of 14
No
No
Hsap\NRXN3
1 of 14
No
No
Hsap\SLIT3
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (16)
Rnor\Cspg4b
12 of 14
Yes
Yes
Rnor\Cspg4
12 of 14
Yes
Yes
Rnor\Fras1
3 of 14
No
Yes
Rnor\Frem1
3 of 14
No
Yes
Rnor\Frem2
3 of 14
No
Yes
Rnor\Frem3
3 of 14
No
Yes
Rnor\Cntnap1
1 of 14
No
No
Rnor\Cntnap3
1 of 14
No
No
Rnor\Cntnap4
1 of 14
No
No
Rnor\Cntnap5a
1 of 14
No
No
Rnor\Cntnap5b
1 of 14
No
No
Rnor\Cntnap5c
1 of 14
No
No
Rnor\LOC304725
1 of 14
No
No
Rnor\Nrxn1
1 of 14
No
No
Rnor\Nrxn2
1 of 14
No
No
Rnor\Nrxn3
1 of 14
No
No
Mus musculus (laboratory mouse) (18)
Mmus\Cspg4b
11 of 14
Yes
Yes
Mmus\Cspg4
11 of 14
Yes
Yes
Mmus\Fras1
3 of 14
No
Yes
Mmus\Frem1
3 of 14
No
Yes
Mmus\Frem2
3 of 14
No
Yes
Mmus\Frem3
3 of 14
No
Yes
Mmus\Agrn
1 of 14
No
No
Mmus\Cntnap1
1 of 14
No
No
Mmus\Cntnap2
1 of 14
No
No
Mmus\Cntnap3
1 of 14
No
No
Mmus\Cntnap4
1 of 14
No
No
Mmus\Cntnap5a
1 of 14
No
No
Mmus\Cntnap5b
1 of 14
No
No
Mmus\Cntnap5c
1 of 14
No
No
Mmus\Egflam
1 of 14
No
No
Mmus\Nrxn1
1 of 14
No
No
Mmus\Nrxn2
1 of 14
No
No
Mmus\Nrxn3
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (14)
Xtro\cspg4b
10 of 13
Yes
Yes
Xtro\LOC116409763
5 of 13
No
Yes
Xtro\slc16a10
2 of 13
No
No
Xtro\asic2
1 of 13
No
Yes
Xtro\b3galt6
1 of 13
No
No
Xtro\cntnap1
1 of 13
No
No
Xtro\cntnap4
1 of 13
No
No
Xtro\ddr1
1 of 13
No
No
Xtro\egflam
1 of 13
No
No
Xtro\frem2
1 of 13
No
Yes
Xtro\htr6
1 of 13
No
Yes
Xtro\lama1
1 of 13
No
No
Xtro\slit3
1 of 13
No
No
Xtro\smarca1
1 of 13
No
No
Danio rerio (Zebrafish) (22)
Drer\cspg4
12 of 14
Yes
Yes
Drer\cspg4ba
11 of 14
No
Yes
Drer\cspg4bb
7 of 14
No
Yes
Drer\frem1a
3 of 14
No
Yes
Drer\frem1b
3 of 14
No
Yes
Drer\frem2a
3 of 14
No
Yes
Drer\frem3
3 of 14
No
Yes
Drer\fras1
2 of 14
No
No
Drer\frem2b
2 of 14
No
Yes
Drer\cntnap1
1 of 14
No
No
Drer\cntnap2a
1 of 14
No
No
Drer\cntnap2b
1 of 14
No
No
Drer\cntnap3
1 of 14
No
No
Drer\cntnap5b
1 of 14
No
No
Drer\cntnap5l
1 of 14
No
No
Drer\egflam
1 of 14
No
No
Drer\LOC110440062
1 of 14
No
Yes
Drer\nrxn1a
1 of 14
No
No
Drer\nrxn1b
1 of 14
No
No
Drer\nrxn2a
1 of 14
No
No
Drer\nrxn3a
1 of 14
No
No
Drer\nrxn3b
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (7)
Cele\C48E7.6
13 of 14
Yes
Yes
Cele\epi-1
1 of 14
No
No
Cele\itx-1
1 of 14
No
No
Cele\lam-3
1 of 14
No
No
Cele\nlr-1
1 of 14
No
No
Cele\nrx-1
1 of 14
No
No
Cele\T19D12.6
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (8)
Agam\AgaP_AGAP008400
12 of 12
Yes
Yes
Agam\AgaP_AGAP001418
1 of 12
No
No
Agam\AgaP_AGAP002793
1 of 12
No
No
Agam\AgaP_AGAP003656
1 of 12
No
No
Agam\AgaP_AGAP004066
1 of 12
No
No
Agam\AgaP_AGAP004993
1 of 12
No
No
Agam\AgaP_AGAP006513
1 of 12
No
No
Agam\AgaP_AGAP007545
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:kon. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (6)
axo
1 of 13
CG31195
1 of 13
ft
1 of 13
LanA
1 of 13
Nrx-1
1 of 13
Nrx-IV
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 3 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CSPG4; chondroitin sulfate proteoglycan 4
    12 of 14
    601172
        FRAS1; Fraser extracellular matrix complex subunit 1
        3 of 14
        607830
        FREM2; FRAS1 related extracellular matrix 2
        3 of 14
        608945
        FREM3; FRAS1 related extracellular matrix 3
        3 of 14
        608946
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            Summary of Genetic Interactions
            Interaction Browsers
            View in FlyBase Interactions Browser   View in MIST tool (external link)
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            kon
            suppressible
            Akap200
            (Harrison et al., 2021)
            kon
            suppressible
            Akt
            (Harrison et al., 2021)
            kon
            suppressible
            CadN2
            (Harrison et al., 2021)
            kon
            suppressible
            eya
            (Harrison et al., 2021)
            kon
            suppressible
            Fak
            (Harrison et al., 2021)
            kon
            suppressible
            ft
            (Harrison et al., 2021)
            kon
            suppressible
            Grip
            (Harrison et al., 2021)
            kon
            suppressible
            IA-2
            (Harrison et al., 2021)
            kon
            suppressible
            Kul
            (Harrison et al., 2021)
            kon
            suppressible
            kuz
            (Harrison et al., 2021)
            kon
            suppressible
            Lar
            (Harrison et al., 2021)
            kon
            suppressible
            metro
            (Harrison et al., 2021)
            kon
            suppressible
            mtm
            (Harrison et al., 2021)
            kon
            suppressible
            mys
            (Harrison et al., 2021)
            kon
            suppressible
            PRL-1
            (Harrison et al., 2021)
            kon
            suppressible
            Ptp4E
            (Harrison et al., 2021)
            kon
            suppressible
            Ptp61F
            (Harrison et al., 2021)
            kon
            suppressible
            Ptp69D
            (Harrison et al., 2021)
            kon
            suppressible
            Ptp99A
            (Harrison et al., 2021)
            kon
            suppressible
            shg
            (Harrison et al., 2021)
            kon
            suppressible
            Ssu72
            (Harrison et al., 2021)
            kon
            suppressible
            Wnt5
            (Harrison et al., 2021)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            LanB2
            enhanceable
            kon
            (Wolfstetter and Holz, 2012)
            qsm
            suppressible
            kon
            (Chu and Hayashi, 2021)
            External Data
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            FlyBase
            External Links
            Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
            External Data
            Class of Gene
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            2L
            Recombination map
            2-53
            Cytogenetic map
            36F5-36F6
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            36F5-36F6
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            Experimentally Determined Recombination Data
            Location

            2-53

            (FlyBase, 2016)

            2-53.3

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (14)
            Genomic Clones (23)
            cDNA Clones (21)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
                Other clones
                RNAi and Array Information
                Linkouts
                DRSC - Results frm RNAi screens
                Antibody Information
                Laboratory Generated Antibodies
                 
                Commercially Available Antibodies
                 
                Cell Line Information
                Publicly Available Cell Lines
                 
                  Other Stable Cell Lines
                   
                    Other Comments

                    Some ventral muscles fail to reach their attachment sites and instead form rounded multinucleated myotubes.

                    (Estrada et al., 2007)

                    kon is required for myotubes to recognise their tendon cell targets and to establish a stable connection during muscle development.

                    (Schnorrer et al., 2007)
                    Relationship to Other Genes
                    Source for database merge of
                    Additional comments
                    Nomenclature History
                    Source for database identify of

                    Source for identity of: perd CG10275

                    (Estrada, 2007.2.25)

                    Source for identity of: kon CG10275

                    (Schnorrer et al., 2007)
                    Nomenclature comments
                    Etymology

                    Named "perdido" ("lost" in Spanish) because muscles fail to find their attachment sites in mutant embryos.

                    (Estrada et al., 2007)

                    The gene is named "perdido", meaning "lost" in Spanish, since the morphology of muscles in mutant embryos indicates that they are not attached to the epidermal tendon cells.

                    (Estrada et al., 2007)

                    The gene is named "kon-tiki" after the raft on which explorer Thor Heyerdahl sailed to Polynesia.

                    (Schnorrer et al., 2007)
                    Synonyms and Secondary IDs (12)
                    Reported As
                    Symbol Synonym
                    CG10275
                    (National Institute of Genetics Fly Stocks, 2022-, Kondo et al., 2017, Hosono et al., 2015, Rebeiz et al., 2011, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2008, Estrada, 2007.2.25, Estrada et al., 2007, Schnorrer et al., 2007, Estrada et al., 2006, Zimmermann et al., 2006)
                    CT28869
                    (Hynes and Zhao, 2000)
                    Kon
                    (Valdivia et al., 2017, Steele et al., 2015, Liu et al., 2011)
                    kon
                    (Reim, 2024.4.19, Sun et al., 2024, Tam and Rand, 2024, National Institute of Genetics Fly Stocks, 2022-, Harrison et al., 2021, Hayes and Melrose, 2021, Ou et al., 2021, Peppriell et al., 2021, Pérez-Moreno et al., 2021, Winbush and Singh, 2021, Nishihara, 2020, Sun et al., 2020, Lavoy et al., 2018, Lee et al., 2018, Loison et al., 2018, Spletter et al., 2018, Bataillé et al., 2017, Losada-Perez et al., 2017, Pérez-Moreno et al., 2017, Gene Disruption Project members, 2016-, Losada-Perez et al., 2016, Wang et al., 2015, Montgomery et al., 2014, Weitkunat and Schnorrer, 2014, Kwon et al., 2013, Wolfstetter and Holz, 2012, Cherbas et al., 2011, Chen et al., 2008, Schnorrer et al., 2007)
                    perd
                    (Pérez-Moreno et al., 2017, Pérez-Moreno et al., 2014, Japanese National Institute of Genetics, 2012.5.21, Estrada et al., 2007, Estrada et al., 2007)
                    Name Synonyms
                    CG10275
                    Kon-Tiki
                    (Kato et al., 2018)
                    Kon-tiki
                    (Dubey et al., 2020, Nishihara, 2020, Losada-Perez, 2018, Pérez-Moreno et al., 2017)
                    Kontiki
                    (Jawkar and Nongthomba, 2020)
                    NG2-like
                    (Hynes and Zhao, 2000)
                    kon-tiki
                    (Ayukawa et al., 2022, Pérez-Moreno et al., 2021, Kondo et al., 2017, Losada-Perez et al., 2017, Losada-Perez et al., 2016, Maartens and Brown, 2015, Wang et al., 2015, Berns et al., 2014, Montgomery et al., 2014, Perkins and Tanentzapf, 2014, Deng et al., 2010, Schnorrer et al., 2008, Schnorrer et al., 2007)
                    kontiki
                    (Dequéant et al., 2015)
                    perdido
                    (Perkins and Tanentzapf, 2014, Estrada, 2007.2.25, Estrada et al., 2007, Estrada et al., 2007)
                    Secondary FlyBase IDs
                      Datasets (0)
                      Study focus (0)
                      Experimental Role
                      Project
                      Project Type
                      Title
                      Study result (0)
                      Result
                      Result Type
                      Title
                      External Crossreferences and Linkouts ( 49 )
                      Sequence Crossreferences
                      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                      Other crossreferences
                      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                      FlyMine - An integrated database for Drosophila genomics
                      InterPro - A database of protein families, domains and functional sites
                      KEGG Genes - Molecular building blocks of life in the genomic space.
                      MARRVEL_MODEL - MARRVEL (model organism gene)
                      Linkouts
                      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                      DroID - A comprehensive database of gene and protein interactions.
                      DRSC - Results frm RNAi screens
                      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                      Flygut - An atlas of the Drosophila adult midgut
                      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                      MIST (protein-protein) - An integrated Molecular Interaction Database
                      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                      Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
                      References (90)