BG:DS07473.3 , PRL
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.45
gene_with_dicistronic_mRNA ; SO:0000722
Gene model reviewed during 6.13
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\PRL-1 using the Feature Mapper tool.
Prior to cellularization, PRL-1 is evenly expressed throughout the syncytium. Following cellularization, PRL-1 levels are relatively low in the newly formed blastoderm, but can be seen in the cytoplasm. As embryogenesis proceeds, PRL-1 remains ubiquitously and cytoplasmically expressed, though most abundant in the amnioserosa in later stages of embryogenesis. Analysis of the first through third larval instar tissues showed that PRL-1 becomes localized to and more abundant at the plasma membrane though cytoplasmic staining is still detected. The larval midgut demonstrated the most dynamic expression, with some cells showing predominant PRL-1 staining at plasma membrane and others showing very high levels of PRL-1 in the cytoplasm. PRL-1 appears to be ubiquitously expressed throughout larval development although with variable levels; the gastric caecum consistently demonstrated very strong staining for PRL-1, while the larval brain was consistently among the lowest. In the developing eye and wing discs, PRL-1 is most abundant at the plasma membrane. Staining in the developing eye demonstrates that PRL-1 levels and localization are similar in both actively dividing cells (anterior to the morphogenetic furrow) and differentiated cells (posterior to the morphogenetic furrow).
GBrowse - Visual display of RNA-Seq signalsView Dmel\PRL-1 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: PRL-1 CG4993
Source for merge of: PRL-1 BcDNA:RE40268
One or more of the processed transcripts for these genes contain several non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by CG46309 (FBgn0284225) and CG4993 (FBgn0024734).
Source for merge of PRL-1 BcDNA:RE40268 was a shared cDNA ( date:030728 ).