FlyBase Allele Report: Dmel\PRL-1[6]

General Information

Symbol

Dmel\PRL-1⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0349224

Feature type

allele

Associated gene

Dmel\PRL-1

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Urwyler et al., 2019)

Progenitor genotype

Cytology

Description

A small in-frame deletion within PRL-1.

(Urwyler et al., 2019)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

2L:16,248,858..16,248,866 [-]

Comment:

Deletion of 9 bases (CGACCATCA0) and insertion of three bases (GAT) causes an in-frame deletion.

Inserted_sequence:

GAT

(Urwyler et al., 2019)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage (with Df(2L)r10)

(Urwyler et al., 2019)

abnormal size | adult stage (with Df(2L)r10)

(Urwyler et al., 2019)

Phenotype Manifest In

mechanosensory neuron | adult stage (with PRL-1²)

(Urwyler et al., 2019)

mechanosensory neuron of posterior dorsocentral bristle (with Df(2L)r10)

(Urwyler et al., 2019)

mechanosensory neuron of posterior dorsocentral bristle (with PRL-1²)

(Urwyler et al., 2019)

neuron projection | adult stage (with Df(2L)r10)

(Urwyler et al., 2019)

neuron projection | adult stage (with PRL-1²)

(Urwyler et al., 2019)

synapse (with PRL-1²)

(Urwyler et al., 2019)

Detailed Description

Statement

Reference

In PRL-1⁶/Df(2L)r10 posterior dorsocentral bristle neurons, terminal arbors on the contralateral branch cover significantly less territory, as compared to controls.

PRL-1²/PRL-1⁶ posterior dorsocentral bristle neurons show a significant decrease in the number of synapses (Brp-positive puncta) in the contralateral branch, but not in the anterior branch, as compared to controls; mechanosensory neurons show a significant decrease in terminal arbor territory, as compared to controls.

(Urwyler et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

PRL-1⁶/PRL-1² has abnormal neuroanatomy | adult stage phenotype, suppressible | partially by Scer\GAL4^pnr-MD237/Avic\GFP^{EGFP.UAS.Tag:PH(hPLCD1)}

(Urwyler et al., 2019)

PRL-1⁶/PRL-1² has abnormal size | adult stage phenotype, suppressible | partially by Scer\GAL4^pnr-MD237/Avic\GFP^{EGFP.UAS.Tag:PH(hPLCD1)}