FB2021_01, released Feb 18, 2021

Gene Group : DUAL SPECIFICITY PHOSPHATASES

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General Information
Name
DUAL SPECIFICITY PHOSPHATASES
Species
D. melanogaster
Symbol
DSP
FlyBase ID
FBgg0000265
Date last reviewed
2015-06-08
Number of members
23
Description
Description

Dual Specificity Phosphatases (DSP) can dephosphorylate both tyrosine and serine/threonine residues. Additionally, DSPs may target a much larger and diverse set of substrates, including phosphoinositide lipids, RNA 5'-triphosphate and carbohydrates. (Adapted from FBrf0227974).

Notes on Group

CG14411, CG5026 and Sbf are predicted to be pseudophosphatases in FBrf0227974.

CG3632, mtm, CG3530, Pten and Plip are also members of the PHOSPHATIDYLINOSITOL PHOSPHATE AND INOSITOL PHOSPHATE PHOSPHATASES gene group.

Source Material
The DUAL SPECIFICITY PHOSPHATASES Gene Group has been compiled by FlyBase curators using the following publication(s): Hatzihristidis et al., 2015, Morrison et al., 2000, and Walchli et al., 2000 .
Key Gene Ontology (GO) terms
Molecular Function
protein tyrosine/serine/threonine phosphatase activity
Biological Process
protein dephosphorylation
Cellular Component
Related Gene Groups
Parent group(s)
PROTEIN TYROSINE PHOSPHATASES
Other related group(s)
PHOSPHATIDYLINOSITOL PHOSPHATE AND INOSITOL PHOSPHATE PHOSPHATASES
Members (23)
For all members:
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
cdc14
cell division cycle 14
(Hatzihristidis et al., 2015, Morrison et al., 2000, Walchli et al., 2000)
CG3632
(Hatzihristidis et al., 2015, Morrison et al., 2000)
CG5026
(Hatzihristidis et al., 2015, Morrison et al., 2000)
CG7378
MKP-like
(Hatzihristidis et al., 2015, Morrison et al., 2000)
CG10089
(Hatzihristidis et al., 2015, Morrison et al., 2000)
CG13197
(Hatzihristidis et al., 2015, Morrison et al., 2000)
CG14411
(Hatzihristidis et al., 2015, Morrison et al., 2000)
CG15528
(Hatzihristidis et al., 2015, Morrison et al., 2000)
EDTP
Egg-derived tyrosine phosphatase
(Hatzihristidis et al., 2015)
Mkp
MAP kinase-specific phosphatase
DMKP
(Hatzihristidis et al., 2015)
Mkp3
Mitogen-activated protein kinase phosphatase 3
DMKP-3, MAP Kinase Phosphatase 3
(Hatzihristidis et al., 2015, Morrison et al., 2000, Walchli et al., 2000)
MKP-4
MAPK Phosphatase 4
(Hatzihristidis et al., 2015, Morrison et al., 2000)
mRNA-cap
mRNA-capping-enzyme
(Hatzihristidis et al., 2015, Morrison et al., 2000)
mtm
myotubularin
(Hatzihristidis et al., 2015, Morrison et al., 2000, Walchli et al., 2000)
Mtmr6
Myotubularin related protein 6
BcDNA:GH04637
(Hatzihristidis et al., 2015, Morrison et al., 2000, Walchli et al., 2000)
PRL-1
PRL-1 phosphatase
PRL, BG:DS07473.3
(Hatzihristidis et al., 2015, Morrison et al., 2000, Walchli et al., 2000)
Pten
Phosphatase and tensin homolog
dPTEN
(Hatzihristidis et al., 2015, Morrison et al., 2000, Walchli et al., 2000)
PTPMT1
Protein tyrosine phosphatase, mitochondrial 1
Plip
(Hatzihristidis et al., 2015, Morrison et al., 2000)
puc
puckered
hrt, l(3)84Eh, vco, hearty
(Hatzihristidis et al., 2015, Morrison et al., 2000, Walchli et al., 2000)
Sbf
SET domain binding factor
Sbf1
(Hatzihristidis et al., 2015)
ssh
slingshot
l(3)01207, Mkph, MKP
(Hatzihristidis et al., 2015, Morrison et al., 2000)
stg
string
cdc25, cdc25string, l(3)01235, EP1213, string/cdc25
(Hatzihristidis et al., 2015, Morrison et al., 2000, Walchli et al., 2000)
twe
twine
Cdc25, twn, mat(2)synHB5, BG:DS02740.1, l(2)35Fh
(Hatzihristidis et al., 2015, Morrison et al., 2000)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
DSP
DUAL SPECIFICITY PHOSPHATASES
Dual specificity protein phosphatases
DUSP
Secondary FlyBase ID(s)
References (4)