Gene Group: PHOSPHATIDYLINOSITOL PHOSPHATE AND INOSITOL PHOSPHATE PHOSPHATASES

General Information

Name

PHOSPHATIDYLINOSITOL PHOSPHATE AND INOSITOL PHOSPHATE PHOSPHATASES

Species

D. melanogaster

Symbol

PI-IPP

FlyBase ID

FBgg0000255

Date last reviewed

2022-11-01

Number of members

Description

Phosphoinositide phosphate (PtdInsP) phosphatases and Inositol phosphate (InsP) phosphatases are enzymes that catalyze the hydrolysis of phosphate groups from inositol. Many of these phosphatases can act on both PtdInsP and InsP substrates. (Adapted from PMID:23681533).

Notes on Group

FBrf0227909 Table I contains a good analysis of PtdIns phosphatase specificity.

CG3632, mtm, Mtmr6, Pten and PTPMT1 are also members of the DUAL SPECIFICITY PHOSPHATASES gene group.

FBrf0246666 includes CG15743, CG7789, CG5026 and CG14411 in a list of 'predicted Drosophila PI phosphatases based on FlyBase annotations and human orthologs' (Table S1). However, these genes are excluded from this group because: (i) CG15743 and CG7789 are the orthologs of BPNT1 & BPNT2, which function primarily as nucleotidases; and (ii) CG5026 and CG14411 are predicted to encode pseudophosphatases in FBrf0227974.

Source Material

The PHOSPHATIDYLINOSITOL PHOSPHATE AND INOSITOL PHOSPHATE PHOSPHATASES Gene Group has been compiled using the following publication(s): Allen et al., 2020, Balakrishnan et al., 2015, Pagliarini et al., 2004, Seeds et al., 2004, Morrison et al., 2000, Chi et al., 1999, and Acharya et al., 1998 .

Key Gene Ontology (GO) terms

Molecular Function

phosphatidylinositol phosphate phosphatase activity

inositol phosphate phosphatase activity

Biological Process

phospholipid dephosphorylation

phosphatidylinositol dephosphorylation

Cellular Component

Related Gene Groups

Parent group(s)

PHOSPHATASES

Other related group(s)