FlyBase Gene Report: Dmel\Kul

General Information

Symbol

Dmel\Kul

Species

D. melanogaster

Name

Kuzbanian-like

Annotation Symbol

CG1964

Feature Type

protein_coding_gene

FlyBase ID

FBgn0039688

Gene Model Status

Current

Stock Availability

9 publicly available

Enzyme Name (EC)

neprilysin (3.4.24.11)

procollagen N-endopeptidase (3.4.24.14)

stromelysin 1 (3.4.24.17)

meprin A (3.4.24.18)

procollagen C-endopeptidase (3.4.24.19)

astacin (3.4.24.21)

stromelysin 2 (3.4.24.22)

matrilysin (3.4.24.23)

gelatinase A (3.4.24.24)

microbial collagenase (3.4.24.3)

neutrophil collagenase (3.4.24.34)

gelatinase B (3.4.24.35)

saccharolysin (3.4.24.37)

pitrilysin (3.4.24.55)

insulysin (3.4.24.56)

O-sialoglycoprotein endopeptidase (3.4.24.57)

mitochondrial intermediate peptidase (3.4.24.59)

nardilysin (3.4.24.61)

macrophage elastase (3.4.24.65)

bontoxilysin (3.4.24.69)

interstitial collagenase (3.4.24.7)

oligopeptidase A (3.4.24.70)

endothelin-converting enzyme 1 (3.4.24.71)

fibrolase (3.4.24.72)

Gene Summary

Kuzbanian-like (Kul) encodes an ADAM metalloprotease involved in regulation of the Notch signaling pathway by cleaving the product of Delta. [Date last reviewed: 2019-07-11] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Gene Group
Interactive Fly

Also Known As

ADAM10

Key Links

Genomic Location

Cytogenetic map

99B9-99B9

Sequence location

3R:29,725,830..29,735,360 [+]

Recombination map

3-99

RefSeq locus

NT_033777 REGION:29725830..29735360

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables metalloendopeptidase activity

inferred from direct assay

(Sapir et al., 2005)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables metalloendopeptidase activity

inferred from electronic annotation with InterPro:IPR001590

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN005236519

(GO Reference Genome Project, 2011-)

enables metallopeptidase activity

inferred from electronic annotation with InterPro:IPR024079, InterPro:IPR034025

(InterPro Project Members, 2004-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in membrane protein ectodomain proteolysis

inferred from direct assay

(Sapir et al., 2005)

involved_in Notch signaling pathway

inferred from mutant phenotype

(Fic et al., 2019, Sapir et al., 2005)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in membrane protein ectodomain proteolysis

inferred from biological aspect of ancestor with PANTHER:PTN005236519

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with UniProtKB:P78536

(Gene Ontology Curators, 2002-)

involved_in Notch signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN001374824

(GO Reference Genome Project, 2011-)

involved_in proteolysis

inferred from electronic annotation with InterPro:IPR001590

(InterPro Project Members, 2004-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in membrane

inferred from sequence or structural similarity with UniProtKB:P78536

(Gene Ontology Curators, 2002-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN005236519

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

ADAM METALLOPROTEASES

Pathway (FlyBase)

POSITIVE REGULATORS OF NOTCH SIGNALING PATHWAY

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

metalloendopeptidase activity

Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1' (3.4.24.11)

Cleaves the N-propeptide of collagen chain alpha1(I) at Pro-|-Gln and of alpha1(II) and alpha2(I) at Ala-|-Gln (3.4.24.14)

Preferential cleavage where P1', P2' and P3' are hydrophobic residues (3.4.24.17)

Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues (3.4.24.18)

Cleavage of the C-terminal propeptide at Ala-|-Asp in type I and II procollagens and at Arg-|-Asp in type III (3.4.24.19)

Hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2' (3.4.24.21)

Similar to stromelysin 1, but action on collagen types III, IV and V is weak (3.4.24.22)

Cleavage of 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in B chain of insulin (3.4.24.23)

No action on collagen types I, II, IV, V (3.4.24.23)

Cleaves gelatin chain alpha2(I) > alpha1(I) (3.4.24.23)

Cleavage of gelatin type I and collagen types IV, V, VII, X (3.4.24.24)

Cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln (3.4.24.24)

Digestion of native collagen in the triple helical region at Xaa-|-Gly bonds (3.4.24.3)

With synthetic peptides, a preference is shown for Gly at P3 and P1', Pro and Ala at P2 and P2', and hydroxyproline, Ala or Arg at P3' (3.4.24.3)

Cleavage of interstitial collagens in the triple helical domain (3.4.24.34)

Unlike EC 3 (3.4.24.34)

4 (3.4.24.34)

24 (3.4.24.34)

7, this enzyme cleaves type III collagen more slowly than type I (3.4.24.34)

Cleavage of gelatin types I and V and collagen types IV and V (3.4.24.35)

Cleavage of Pro-|-Phe and Ala-|-Ala bonds (3.4.24.37)

Preferential cleavage of 16-Tyr-|-Leu-17 and 25-Phe-|-Tyr-26 bonds of oxidized insulin B chain (3.4.24.55)

Also acts on other substrates of Mw less than 7 kDa such as insulin and glucagon (3.4.24.55)

Degradation of insulin, glucagon and other polypeptides (3.4.24.56)

No action on proteins (3.4.24.56)

Hydrolysis of O-sialoglycoproteins (3.4.24.57)

Cleaves 31-Arg-|-Asp-32 bond in glycophorin A (3.4.24.57)

Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated (3.4.24.57)

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion (3.4.24.59)

Hydrolysis of polypeptides, preferably at -Xaa-|-Arg-Lys-, and less commonly at -Arg-|-Arg-Xaa-, in which Xaa is not Arg or Lys (3.4.24.61)

Hydrolysis of soluble and insoluble elastin (3.4.24.65)

Specific cleavages are also produced at 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in the B chain of insulin (3.4.24.65)

Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin (3.4.24.69)

No detected action on small molecule substrates (3.4.24.69)

Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at 775-Gly-|-Ile-776 in the alpha1(I) chain (3.4.24.7)

Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue (3.4.24.7)

Hydrolysis of oligopeptides, with broad specificity (3.4.24.70)

Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-|-Gly-Pro-Ala is cleaved, but not Z-(Gly)(5) (3.4.24.70)

Hydrolysis of the 21-Trp-|-Val-22 bond in big endothelin to form endothelin 1 (3.4.24.71)

Hydrolysis of 14-Ala-|-Leu-15 in insulin B chain and 413-Lys-|-Leu-414 in alpha-chain of fibrinogen (3.4.24.72)

Summaries

Gene Snapshot

Kuzbanian-like (Kul) encodes an ADAM metalloprotease involved in regulation of the Notch signaling pathway by cleaving the product of Delta. [Date last reviewed: 2019-07-11]

Gene Group (FlyBase)

ADAM METALLOPROTEASES -: A Disintegrin And Metalloprotease (ADAM) proteins belong to the metzincin superfamily of metalloproteases. ADAM proteins are characterized by a highly conserved domain organization that generally includes a prodomain, metalloprotease domain, disintegrin-like domain, cysteine rich domain, EGF-like domain, transmembrane domain and a cytoplasmic domain. The metalloprotease domain is attributed to a process known as ectodomain shedding in which it cleaves at cell surfaces to release the ectodomains of membrane proteins. ADAM proteases are included in MEROPS family M12, subfamily B. (Adapted from FBrf0214506 and FBrf0211961).

Pathway (FlyBase)

POSITIVE REGULATORS OF NOTCH SIGNALING PATHWAY -: The Notch receptor signaling pathway is activated by the binding of the transmembrane receptor Notch (N) to transmembrane ligands, Dl or Ser, presented on adjacent cells. This results in the proteolytic cleavage of N, releasing the intracellular domain (NICD). NICD translocates into the nucleus, interacting with Su(H) and mam to form a transcription complex, which up-regulates transcription of Notch-responsive genes. Positive regulators of the pathway enhance the signal from the sending cell or the response in the receiving cell. (Adapted from FBrf0225731 and FBrf0192604).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Kul for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VAI2)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.49

Multiphase exon postulated: exon reading frame differs in alternative transcripts.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Kul-RA

FBtr0085460

NM_143459

7577

1537

Kul-RB

FBtr0339717

NM_001300660

7623

1537

Kul-RC

FBtr0339718

NM_001300661

7650

985

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Kul-PA

FBpp0084826

168.8

1537

9.47

FBpp0308774

168.8

1537

9.47

FBpp0308775

110.3

985

6.53

A0A0B4LHU2

NP_001287590

AHN57589

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1537 aa isoforms: Kul-PA, Kul-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Kul using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Kul_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.83

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Kul in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Kul

View exonic expression by tissue for Dmel\Kul

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43501/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039688

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039688

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039688

Flygut - An atlas of the Drosophila adult midgut

FBgn0039688

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 4 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Kul

Transgenic constructs containing regulatory region of Kul

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Kul^GD12729

viable

Kul^{CR00477-TG4.1}

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Kul^GD12729

viable, with Scer\GAL4^tin.CΔ4

Kul^GD12729

Sterility

Allele

fertile

Kul^{CR00477-TG4.1}

Other Phenotypes

Allele

abnormal size | embryonic stage, with Scer\GAL4^sns.PK

Kul^GD12729

abnormal size | embryonic stage, with Scer\GAL4^twi.PB

Kul^GD12729

some die during pupal stage, with Scer\GAL4^pnr-MD237

Kul^GD12729

visible, with Scer\GAL4^dome-PG14

Kul^HMC03803

visible, with Scer\GAL4^nub-AC-62

Kul^HMC03803

visible, with Scer\GAL4^pnr-MD237

Kul^GD12729

Phenotype manifest in

Allele

larval muscle system | embryonic stage, with Scer\GAL4^how-24B

Kul^GD12729

larval muscle system | embryonic stage, with Scer\GAL4^sns.PK

Kul^GD12729

larval muscle system | embryonic stage, with Scer\GAL4^twi.PB

Kul^GD12729

mesonotum, with Scer\GAL4^pnr-MD237

Kul^GD12729

stalk follicle cell | increased number, with Scer\GAL4^how-24B

Kul^RNAi.UAS.pro

stalk follicle cell | increased number, with Scer\GAL4^neur-P72

Kul^RNAi.UAS.pro

trichogen cell, with Scer\GAL4^pnr-MD237

Kul^GD12729

wing, with Scer\GAL4^Bx-MS1096

Kul^RNAi.UAS.pro

wing, with Scer\GAL4^dome-PG14

Kul^HMC03803

wing, with Scer\GAL4^nub-AC-62

Kul^HMC03803

wing, with Scer\GAL4^sd-SG29.1

Kul^RNAi.UAS.pro

wing hair | increased number, with Scer\GAL4^salm-459.2

Kul^RNAi.UAS.pro

wing margin, with Scer\GAL4^sd-SG29.1

Kul^RNAi.UAS.pro

wing vein, with Scer\GAL4^salm-459.2

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (39)

Hsap\ADAM10

6 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (36)

Rnor\Adam10

5 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Yes

Rnor\Adam5

1 of 14

Rnor\Adam6

1 of 14

Rnor\Adam26a

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\LOC103690152

1 of 14

Yes

Mus musculus (laboratory mouse) (40)

Mmus\Adam10

6 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Gm33242

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (25)

Xtro\adam10

4 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (20)

Drer\adam10a

7 of 14

Yes

6 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Drer\si:ch1073-396h14.1

2 of 14

Yes

Drer\zgc:174164

2 of 14

Drer\adam12

1 of 14

Yes

Drer\adam19a

1 of 14

Drer\adam28

1 of 14

Drer\LOC101882358

1 of 14

Yes

Drer\LOC101884782

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (7)

Cele\sup-17

5 of 14

Yes

3 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (9)

Agam\AgaP_AGAP003070

11 of 12

Yes

4 of 12

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Kul. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (7)

kuz

4 of 13

Tace

4 of 13

Meltrin

2 of 13

mmd

2 of 13

AdamTS-A

1 of 13

CG34298

1 of 13

stl

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

ADAM10; ADAM metallopeptidase domain 10

model of reticulate acropigmentation of Kitamura

IEA

(FlyBase, 2019-)

model of Alzheimer's disease 18

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ADAM10; ADAM metallopeptidase domain 10

6 of 14

602192

ADAM17; ADAM metallopeptidase domain 17

3 of 14

603639

neonatal inflammatory skin and bowel disease 1

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

kon

suppressible

Kul

(Harrison et al., 2021)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0039688

Pathways

Signaling Pathways (FlyBase)

POSITIVE REGULATORS OF NOTCH SIGNALING PATHWAY

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Efferocytosis

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-99

Cytogenetic map

99B9-99B9

Sequence location

3R:29,725,830..29,735,360 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

99B9-99B9

Limits computationally determined from genome sequence between P{PZ}l(3)06743⁰⁶⁷⁴³ and P{PZ}ncd⁰⁵⁸⁸⁴

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-99

(FlyBase, 2016)

3-96.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

30071

w¹¹¹⁸; P{EP}Kul^G4260

62319

y¹ v¹; P{TRiP.HMJ23676}attP40/CyO

78922

y¹ w^*; TI{CRIMIC.TG4.1}Kul^{CR00477-TG4.1}

55653

y¹ sc^* v¹ sev²¹; P{TRiP.HMC03803}attP40

NIG-Fly

1964R-2

P{NIG.1964R}2

1964R-3

P{NIG.1964R}3

HMJ23676

y¹ v¹; P{TRiP.HMJ23676}attP40/CyO

VDRC

v105983

P{KK101858}VIE-260B

v28347

w¹¹¹⁸; P{GD12729}v28347

Genomic Clones (13)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (16)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0039688

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0039688

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

ADAM10

(Lieber et al., 2002)

CG1964

(Hosono et al., 2015, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009)

CT3146

(Hynes and Zhao, 2000)

Kul

(Bossen et al., 2023, Anqueira-González et al., 2021, Mukherjee et al., 2020, Gene Disruption Project members, 2018-, Wu et al., 2018, Japanese National Institute of Genetics, 2012.5.21, Xu and Gridley, 2012, Assa-Kunik et al., 2007)

kul

(Harrison et al., 2021, Petri et al., 2019, Reinhardt et al., 2019, Yan and Perrimon, 2015)

Name Synonyms

ADAM10

(Revici et al., 2022)

Kuzbanian-like

(Pinot and Le Borgne, 2024, Xu and Gridley, 2012, Meyer et al., 2011, Assa-Kunik et al., 2007, Assa-Kunik et al., 2005, Sapir et al., 2005)

kuzbanian

(Josserand et al., 2023)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 36 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43501

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VAI2

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VAI2

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43501/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039688

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039688

FlyMine - An integrated database for Drosophila genomics

FBgn0039688

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1964

MARRVEL_MODEL - MARRVEL (model organism gene)

43501

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0039688

DroID - A comprehensive database of gene and protein interactions.

FBgn0039688

DRSC - Results frm RNAi screens

FBgn0039688

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Kul_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039688

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0039688

Flygut - An atlas of the Drosophila adult midgut

FBgn0039688

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC032184

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Efferocytosis

References (54)

The following external sites may use different assemblies or annotations than FlyBase.

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