FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term metallopeptidase activity ID (Ontology) GO:0008237 (Gene Ontology)
Definition Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
Comment
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  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION      58
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 metallopeptidase activity (all annotations which use CV term, excluding "NOT" statements)       4     58
     enables | metallopeptidase activity       --      58
 NOT | enables | metallopeptidase activity       --       5
Spanning Tree (Parents/Children)
Only view relationship: 
hydrolase activity_______________________
catalytic activity, acting on a protein__|
                                         peptidase activity
                                          |__metallopeptidase activity  150 rec.
                                              |__metal-dependent deNEDDylase activity 2 rec.
                                              |__metal-dependent deubiquitinase activity 7 rec.
                                              |__metalloendopeptidase activity 64 rec.
                                              |   |__metalloendopeptidase activity involved in amyloid precursor protein catabolic process
                                              |__metalloexopeptidase activity 70 rec.
                                                  |__metalloaminopeptidase activity 26 rec.
                                                  |__metallocarboxypeptidase activity(+) 22 rec.
                                                  |__metallodipeptidase activity 5 rec.
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Is a peptidase activity
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Synonyms
  • "metalloprotease activity" NARROW
    "metalloproteinase activity" NARROW
Secondary IDs
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Reactome:R-HSA-157629 "NOTCH2-ligand complex is cleaved to produce NEXT2"
Reactome:R-HSA-157632 "Complex of NOTCH1 with its ligand is cleaved to produce NEXT1"
Reactome:R-HSA-193679 "alpha-secretase cleaves the p75NTR extracellular domain"
Reactome:R-HSA-2022368 "MME:Zn2+ (Neprilysin) hydrolyses AGT(34-42)"
Reactome:R-HSA-2022393 "ANPEP:Zn2+ hydrolyzes Angiotensin-(2-8) to Angiotensin-(3-8)"
Reactome:R-HSA-2022396 "MME:Zn2+ (Neprilysin) hydrolyses AGT(34-43)"
Reactome:R-HSA-2022399 "ENPEP:Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8)"
Reactome:R-HSA-2220944 "ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants"
Reactome:R-HSA-2220976 "NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding"
Reactome:R-HSA-2666278 "NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1"
Reactome:R-HSA-2730752 "NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding"
Reactome:R-HSA-3928660 "ADAM10 cleaves EFNAs"
Reactome:R-HSA-5211340 "Anthrax lef cleaves target cell MAP2K1 (MEK1)"
Reactome:R-HSA-5211356 "Anthrax lef cleaves target cell MAP2K2 (MEK2)"
Reactome:R-HSA-5211387 "Anthrax lef cleaves target cell MAP2K7 (MEK7)"
Reactome:R-HSA-5211391 "Anthrax lef cleaves target cell MAP2K4 (MEK4)"
Reactome:R-HSA-5211400 "Anthrax lef cleaves target cell MAP2K3 (MEK3)"
Reactome:R-HSA-5211405 "Anthrax lef cleaves target cell MAP2K6 (MEK6)"
Reactome:R-HSA-8986181 "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)"
Reactome:R-HSA-9013284 "NOTCH3-ligand complex is cleaved to produce NEXT3"
Reactome:R-HSA-9604264 "ADAM10 cleaves NOTCH4"
Reactome:R-HSA-9662837 "p-S,T-ADAM17(215-827):Zn2+ cleaves CD163"
Reactome:R-HSA-9759522 "Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform"