FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term metallopeptidase activity ID (Ontology) GO:0008237 (Gene Ontology)
Definition Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Gene Groups Genes
 metallopeptidase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | metallopeptidase activity       --
 NOT | enables | metallopeptidase activity       --
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hydrolase activity_______________________
catalytic activity, acting on a protein__|
                                         peptidase activity
                                          |__metallopeptidase activity  168 rec.
                                              |__metal-dependent deNEDDylase activity 2 rec.
                                              |__metal-dependent deubiquitinase activity 8 rec.
                                              |__metalloendopeptidase activity 74 rec.
                                              |   |__metalloendopeptidase activity involved in amyloid precursor protein catabolic process
                                              |__metalloexopeptidase activity 75 rec.
                                                  |__metalloaminopeptidase activity 31 rec.
                                                  |__metallocarboxypeptidase activity(+) 22 rec.
                                                  |__metallodipeptidase activity 5 rec.
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Synonyms
  • "metalloprotease activity" NARROW
    "metalloproteinase activity" NARROW
Secondary IDs
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Reactome:R-HSA-157629 "NOTCH2-ligand complex is cleaved to produce NEXT2"
Reactome:R-HSA-157632 "Complex of NOTCH1 with its ligand is cleaved to produce NEXT1"
Reactome:R-HSA-193679 "alpha-secretase cleaves the p75NTR extracellular domain"
Reactome:R-HSA-2022368 "MME:Zn2+ (Neprilysin) hydrolyses AGT(25-33) (Angiotensin-(1-9)) to AGT(25-31) (Angiotensin-(1-7)"
Reactome:R-HSA-2022393 "ANPEP:Zn2+ hydrolyzes AGT(26-32) (Angiotensin-(2-8)) to AGT(27-32) (Angiotensin-(3-8))"
Reactome:R-HSA-2022396 "MME:Zn2+ (Neprilysin) hydrolyses AGT(25-34) (Angiotensin-(1-10)) to AGT(25-31) (Angiotensin-(1-7))"
Reactome:R-HSA-2022399 "ENPEP:Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(26-32) (Angiotensin-(2-8))"
Reactome:R-HSA-2220944 "ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants"
Reactome:R-HSA-2220976 "NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding"
Reactome:R-HSA-2666278 "NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1"
Reactome:R-HSA-2730752 "NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding"
Reactome:R-HSA-3928660 "ADAM10 cleaves EFNAs"
Reactome:R-HSA-5211340 "Anthrax lef cleaves target cell MAP2K1 (MEK1)"
Reactome:R-HSA-5211356 "Anthrax lef cleaves target cell MAP2K2 (MEK2)"
Reactome:R-HSA-5211387 "Anthrax lef cleaves target cell MAP2K7 (MEK7)"
Reactome:R-HSA-5211391 "Anthrax lef cleaves target cell MAP2K4 (MEK4)"
Reactome:R-HSA-5211400 "Anthrax lef cleaves target cell MAP2K3 (MEK3)"
Reactome:R-HSA-5211405 "Anthrax lef cleaves target cell MAP2K6 (MEK6)"
Reactome:R-HSA-8986181 "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)"
Reactome:R-HSA-9013284 "NOTCH3-ligand complex is cleaved to produce NEXT3"
Reactome:R-HSA-9604264 "ADAM10 cleaves NOTCH4"
Reactome:R-HSA-9662837 "p-S,T-ADAM17(215-827):Zn2+ cleaves CD163"
Reactome:R-HSA-9759522 "Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform"