FlyBase Gene Report: Dmel\Tace

General Information

Symbol

Dmel\Tace

Species

D. melanogaster

Name

Tace

Annotation Symbol

CG7908

Feature Type

protein_coding_gene

FlyBase ID

FBgn0039734

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Summary

Tace (Tace) encodes a transmembrane anchored, cell surface metalloprotease and member of the ADAM family of proteins. The product of Tace, along with the related ADAM protease encoded by kuz, performs ectodomain shedding by cleaving cell surface receptors and/or ligands to affect cell-cell signaling or adhesion. Both proteases are implicated in the Notch signaling pathway. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

99D1-99D1

Sequence location

3R:30,000,530..30,003,678 [+]

Recombination map

3-100

RefSeq locus

NT_033777 REGION:30000530..30003678

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables metalloendopeptidase activity

inferred from direct assay

(Zang et al., 2022, Muliyil et al., 2020, Sapir et al., 2005)

inferred from mutant phenotype

(Agrawal et al., 2016)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables metalloendopeptidase activity

inferred from electronic annotation with InterPro:IPR001590

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN005236519

(GO Reference Genome Project, 2011-)

enables metallopeptidase activity

inferred from electronic annotation with InterPro:IPR024079, InterPro:IPR034025

(InterPro Project Members, 2004-)

Biological Process (9 terms)

Terms Based on Experimental Evidence (8 terms)

CV Term

Evidence

References

involved_in commissural neuron axon guidance

inferred from mutant phenotype

(Zang et al., 2022)

involved_in membrane protein ectodomain proteolysis

inferred from direct assay

(Zang et al., 2022, Muliyil et al., 2020, Sapir et al., 2005)

inferred from mutant phenotype

(Agrawal et al., 2016)

involved_in negative regulation of multicellular organism growth

inferred from mutant phenotype

(Agrawal et al., 2016)

acts_upstream_of negative regulation of reactive oxygen species biosynthetic process

inferred from mutant phenotype

(Muliyil et al., 2020)

involved_in Notch receptor processing

inferred from mutant phenotype

(Lieber et al., 2002)

involved_in Notch signaling pathway

inferred from mutant phenotype

(Delwig and Rand, 2008)

acts_upstream_of positive regulation of programmed cell death

inferred from genetic interaction with FLYBASE:egr; FB:FBgn0033483

(Chabu and Xu, 2014)

involved_in tumor necrosis factor-mediated signaling pathway

inferred from genetic interaction with FLYBASE:egr; FB:FBgn0033483

(Chabu and Xu, 2014)

inferred from mutant phenotype

(Agrawal et al., 2016)

inferred from direct assay

(Muliyil et al., 2020)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in membrane protein ectodomain proteolysis

inferred from sequence or structural similarity with UniProtKB:P78536

(Gene Ontology Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN005236519

(GO Reference Genome Project, 2011-)

involved_in Notch signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN001374824

(GO Reference Genome Project, 2011-)

involved_in proteolysis

inferred from electronic annotation with InterPro:IPR001590

(InterPro Project Members, 2004-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in membrane

inferred from sequence or structural similarity with UniProtKB:P78536

(Gene Ontology Curators, 2002-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN005236519

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

ADAM METALLOPROTEASES

Pathway (FlyBase)

NOTCH SIGNALING PATHWAY CORE COMPONENTS

TNFalpha-EIGER SIGNALING PATHWAY CORE COMPONENTS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

ADAM METALLOPROTEASES -: A Disintegrin And Metalloprotease (ADAM) proteins belong to the metzincin superfamily of metalloproteases. ADAM proteins are characterized by a highly conserved domain organization that generally includes a prodomain, metalloprotease domain, disintegrin-like domain, cysteine rich domain, EGF-like domain, transmembrane domain and a cytoplasmic domain. The metalloprotease domain is attributed to a process known as ectodomain shedding in which it cleaves at cell surfaces to release the ectodomains of membrane proteins. ADAM proteases are included in MEROPS family M12, subfamily B. (Adapted from FBrf0214506 and FBrf0211961).

Pathway (FlyBase)

NOTCH SIGNALING PATHWAY CORE COMPONENTS -: The Notch receptor signaling pathway is activated by the binding of the transmembrane receptor Notch (N) to transmembrane ligands, Delta or Ser, presented on adjacent cells. This results in the proteolytic cleavage of N, releasing the intracellular domain (NICD). NICD translocates into the nucleus, interacting with Su(H) and mam to form a transcription complex, which up-regulates transcription of Notch-responsive genes. Core pathway components are required for signaling from the sending cell and response in the receiving cell. (Adapted from FBrf0225731 and FBrf0192604).
TNFalpha-EIGER SIGNALING PATHWAY CORE COMPONENTS -: The Tumor Necrosis Factor α (TNFα) signaling pathway is activated by Eiger (egr) binding to a member of the TNF receptor superfamily. The signal is primarily transduced via the Jun N-terminal kinase (JNK) cascade, leading to cell death. (Adapted from FBrf0225608.)

Summary (Interactive Fly)

an active metalloprotease - causes the shedding of cell surface proteins including the Drosophila TNF homologue Eiger - cleaves Fra to regulate midline crossing of commissural axons - ADAM17, TNF and the TNF receptor acts in pigmented glial cells of the Drosophila retina - mutation leads to age-related degeneration of both glia and neurons, preceded by an abnormal accumulation of glial lipid droplets - cleaves Neuroligin3 at its extracellular acetylcholinesterase-like domain to generate the N-terminal fragment essential for maintaining proper locomotor activity - active in fat body allowing the cleavage and release of adipose Eiger into the hemolymph - in the brain IPCs, Eiger activates its receptor Grindelwald, leading to JNK-dependent inhibition of insulin production - activates Notch in a ligand-independent manner - targets Delta

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Tace for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VAC5)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Tace-RA

FBtr0085551

NM_170455

2408

732

Tace-RB

FBtr0085550

NM_143502

2322

262

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Tace-PA

FBpp0084917

83.1

732

7.19

FBpp0084916

30.0

262

7.25

NP_651759

AAN14205

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Domain

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

(UniProt, Q9VAC5)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tace using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Tace_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.19

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13 -- 14

ventral nerve cord

(Mushtaq et al., 2022)

Additional Descriptive Data

Tace transcripts are maternally deposited. They are broadly expressed from embryonic stage 13, particularly in the ventral nerve cord.

(Mushtaq et al., 2022)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Tace in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Tace

View exonic expression by tissue for Dmel\Tace

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43558/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039734

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039734

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039734

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7908

Flygut - An atlas of the Drosophila adult midgut

FBgn0039734

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Tace

Transgenic constructs containing regulatory region of Tace

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3R)Exel6213

(Ryder, 2004.4.26)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

viable

Tace¹

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Tace^GD572

viable, with Scer\GAL4^Mef2.PR

Tace^GD572

viable, with Scer\GAL4^pnr-MD237

Tace^GD572

viable, with Scer\GAL4^tin.CΔ4

Tace^GD572

Other Phenotypes

Allele

abnormal locomotor behavior | adult stage

Tace^KO

abnormal neuroanatomy | adult stage, with Scer\GAL4^GMR.PFa

Tace^GD572

abnormal neuroanatomy | adult stage, with Scer\GAL4^sv.PJ

Tace^GD572

abnormal neuroanatomy | adult stage | progressive

Tace¹

abnormal neuroanatomy | adult stage | progressive (with Df(3R)BSC794)

Tace¹

abnormal neuroanatomy | embryonic stage

Tace¹⁹

abnormal neuroanatomy | embryonic stage (with Tace¹⁷)

Tace¹⁹

abnormal neuroanatomy | embryonic stage (with Tace¹⁹)

Tace¹⁷

decreased cell number | adult stage, with Scer\GAL4^GMR.PFa

Tace^GD572

decreased cell number | adult stage, with Scer\GAL4^sv.PJ

Tace^GD572

decreased cell number | adult stage | progressive

Tace¹

decreased cell number | adult stage | progressive (with Df(3R)BSC794)

Tace¹

increased cell size | adult stage

Tace¹

increased cell size | adult stage (with Df(3R)BSC794)

Tace¹

short lived

Tace¹

wild-type, with Scer\GAL4^Bx-MS1096

Tace^RNAi.UAS.cSa

Phenotype manifest in

Allele

axon | embryonic stage

Tace¹⁹

axon | embryonic stage (with Tace¹⁷)

Tace¹⁹

axon | embryonic stage (with Tace¹⁹)

Tace¹⁷

commissure | embryonic stage

Tace¹⁹

connective | embryonic stage

Tace¹⁹

eye photoreceptor cell | decreased number

Tace¹

eye photoreceptor cell | decreased number, with Scer\GAL4^GMR.PFa

Tace^GD572

eye photoreceptor cell | decreased number, with Scer\GAL4^sv.PJ

Tace^GD572

eye photoreceptor cell | decreased number (with Df(3R)BSC794)

Tace¹

larval EW neuron | embryonic stage

Tace¹⁹

larval interneuron | embryonic stage

Tace¹⁹

larval interneuron | embryonic stage (with Tace¹⁷)

Tace¹⁹

larval interneuron | embryonic stage (with Tace¹⁹)

Tace¹⁷

lipid droplet | adult stage | increased number

Tace¹

lipid droplet | adult stage | increased number, with Scer\GAL4^Act5C.PI

Tace^GD572

lipid droplet | adult stage | increased number, with Scer\GAL4^sv.PJ

Tace^GD572

lipid droplet | adult stage | increased number (with Df(3R)BSC794)

Tace¹

pigment cell | decreased number

Tace¹

pigment cell | decreased number, with Scer\GAL4^GMR.PFa

Tace^GD572

pigment cell | decreased number (with Df(3R)BSC794)

Tace¹

retina

Tace¹

retina, with Scer\GAL4^GMR.PFa

Tace^GD572

retina, with Scer\GAL4^sv.PJ

Tace^GD572

retina (with Df(3R)BSC794)

Tace¹

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (39)

Hsap\ADAM17

14 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (36)

Rnor\Adam17

13 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Yes

Rnor\Adam5

1 of 14

Rnor\Adam6

1 of 14

Rnor\Adam26a

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\LOC103690152

1 of 14

Yes

Mus musculus (laboratory mouse) (40)

Mmus\Adam17

14 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Gm33242

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (26)

Xtro\adam17

8 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (20)

Drer\adam17a

14 of 14

Yes

Drer\adam17b

14 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Drer\si:ch1073-396h14.1

2 of 14

Yes

Drer\zgc:174164

2 of 14

Drer\adam12

1 of 14

Yes

Drer\adam19a

1 of 14

Drer\adam28

1 of 14

Drer\LOC101882358

1 of 14

Yes

Drer\LOC101884782

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (10)

Cele\adm-4

14 of 14

Yes

3 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (9)

Agam\AgaP_AGAP002381

12 of 12

Yes

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Tace. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (7)

Kul

4 of 13

kuz

4 of 13

mmd

3 of 13

Meltrin

2 of 13

AdamTS-A

1 of 13

CG34298

1 of 13

stl

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

ADAM17; ADAM metallopeptidase domain 17

model of neonatal inflammatory skin and bowel disease 1

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ADAM17; ADAM metallopeptidase domain 17

14 of 14

603639

neonatal inflammatory skin and bowel disease 1

ADAM10; ADAM metallopeptidase domain 10

3 of 14

602192

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Tace - fra

anti tag coimmunoprecipitation, anti tag western blot, western blot

(Zang et al., 2022)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Tace

suppressible

bmm

(Muliyil et al., 2020)

Tace

suppressible

bsk

(Muliyil et al., 2020)

Tace

suppressible

Cat

(Muliyil et al., 2020)

Tace

enhanceable

comm

(Zang et al., 2022)

Tace

enhanceable

fra

(Zang et al., 2022)

Tace

enhanceable

Psn

(Zang et al., 2022)

Tace

suppressible

Sod1

(Muliyil et al., 2020)

Tace

suppressible

Sod2

(Muliyil et al., 2020)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

egr

suppressible

Tace

(Chabu and Xu, 2014)

egr|bsk

enhanceable

Tace

(Chabu and Xu, 2014)

fra

enhanceable

Tace

(Zang et al., 2022)

fra

suppressible

Tace

(Zang et al., 2022)

Pgam1

suppressible

Tace

(Rodríguez-Vázquez et al., 2024)

Ras85D

suppressible

Tace

(Chabu and Xu, 2014)

robo1|sli

suppressible

Tace

(Zang et al., 2022)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0039734

Pathways

Signaling Pathways (FlyBase)

NOTCH SIGNALING PATHWAY CORE COMPONENTS
TNFalpha-EIGER SIGNALING PATHWAY CORE COMPONENTS

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9VAC5

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-100

Cytogenetic map

99D1-99D1

Sequence location

3R:30,000,530..30,003,678 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

99D1-99D1

Limits computationally determined from genome sequence between P{PZ}ncd⁰⁵⁸⁸⁴ and P{lacW}l(3)s2500^s2500

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-100

(FlyBase, 2016)

3-97.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

91497

y¹ w^*; TI{CRIMIC.TG4.1}Tace^{CR02267-TG4.1}

78153

y¹ sc^* v¹ sev²¹; P{TOE.GS01297}attP40

79840

y¹ sc^* v¹ sev²¹; P{TKO.GS01786}attP40

77183

y¹ sc^* v¹ sev²¹; P{TRiP.HMC06496}attP40

VDRC

v106335

P{KK109440}VIE-260B

v2733

w¹¹¹⁸; P{GD572}v2733

Genomic Clones (16)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (31)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_RE65757

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0039734

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0039734

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Tace CG7908

(Sapir, 2004.1.14)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

ADAM17

(Muliyil et al., 2020)

CG7908

(Zacharioudaki and Bray, 2014, Keleman et al., 2009.8.5, Perkins et al., 2009, Burgler and Macdonald, 2005)

CT23908

(Hynes and Zhao, 2000)

DTACE

(Sapir et al., 2005)

TACE

(De Groef et al., 2024, Pinot and Le Borgne, 2024, Sachan et al., 2024, Ratnaparkhi and Sudhakaran, 2022, Meschi and Delanoue, 2021, Ohhara et al., 2021, Manière et al., 2020, Wu et al., 2018, Agrawal et al., 2016, Palmer and Deng, 2015, Guruharsha et al., 2012, Meyer et al., 2011, Delwig and Rand, 2008, Sapir, 2004.1.14, Lieber et al., 2002, Lee et al., 2001)

TNF-α converting enzyme

(Agrawal et al., 2016)

Tace

(GenetiVision Corporation, 2026-, Rodríguez-Vázquez et al., 2024, Bossen et al., 2023, De Groef et al., 2021, Gene Disruption Project members, 2018-, Transgenic RNAi Project members, 2017-, Chabu and Xu, 2014, Zacharioudaki and Bray, 2014, Pecot et al., 2013, Nfonsam et al., 2012, Rettie and Dorus, 2012, Slattery et al., 2011, Wasbrough et al., 2010, Ayroles et al., 2009)

tace

(Zang et al., 2022, Pathak and Varghese, 2021)

Name Synonyms

Tace

tumor necrosis factor-alpha-converting enzyme

(Pecot et al., 2013)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 47 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43558

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VAC5

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VAC5

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VAC5

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43558/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039734

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039734

FlyMine - An integrated database for Drosophila genomics

FBgn0039734

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG7908

MARRVEL_MODEL - MARRVEL (model organism gene)

43558

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0039734

DroID - A comprehensive database of gene and protein interactions.

FBgn0039734

DRSC - Results frm RNAi screens

FBgn0039734

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Tace_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039734

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0039734

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7908

Flygut - An atlas of the Drosophila adult midgut

FBgn0039734

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC001039

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9VAC5

References (69)

The following external sites may use different assemblies or annotations than FlyBase.

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