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General Information
Name
Notch Signaling Pathway Core Components
Species
D. melanogaster
Symbol
NTCH-C
FlyBase ID
FBgg0001064
Date last reviewed
2019-01-23
Number of members
12
Description
Description
The Notch receptor signaling pathway is activated by the binding of the transmembrane receptor Notch (N) to transmembrane ligands, Dl or Ser, presented on adjacent cells. This results in the proteolytic cleavage of N, releasing the intracellular domain (NICD). NICD translocates into the nucleus, interacting with Su(H) and mam to form a transcription complex, which up-regulates transcription of Notch-responsive genes. (Adapted from FBrf0225731 and FBrf0192604). Core pathway components are required for signaling from the sending cell and response in the receiving cell.
Notes and selected reviews
Biological Process Gene Ontology (GO) term(s)
Related Gene Groups
Other related group(s)
Physical Interaction Network
Members (12)
For all members:
External Data
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
NTCH-C
Notch Signaling Pathway Core Components
Secondary FlyBase ID(s)
References (52)