The Notch receptor signaling pathway is activated by the binding of the transmembrane receptor Notch (N
) to transmembrane ligands, Dl
, presented on adjacent cells. This results in the proteolytic cleavage of N
, releasing the intracellular domain (NICD). NICD translocates into the nucleus, interacting with Su(H)
to form a transcription complex, which up-regulates transcription of Notch-responsive genes. (Adapted from FBrf0225731
). Core pathway components are required for signaling from the sending cell and response in the receiving cell.