FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term metalloendopeptidase activity ID (Ontology) GO:0004222 (Gene Ontology)
Definition Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
Comment
Links to External Ontologies
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Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION      48
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 metalloendopeptidase activity (all annotations which use CV term, excluding "NOT" statements)      16     48
     enables | metalloendopeptidase activity       --      48
Spanning Tree (Parents/Children)
Only view relationship: 
peptidase activity
 |__endopeptidase activity_____
 |__metallopeptidase activity__|
                               metalloendopeptidase activity  64 rec.
                                |__metalloendopeptidase activity involved in amyloid precursor protein catabolic process
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Is a endopeptidase activity
metallopeptidase activity
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Synonyms
  • "metalloendoprotease activity" NARROW
    "metalloendoproteinase activity" NARROW
Secondary IDs
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EC:3.4.24.-
EC:3.4.24.11
EC:3.4.24.14
EC:3.4.24.17
EC:3.4.24.18
EC:3.4.24.19
EC:3.4.24.21
EC:3.4.24.22
EC:3.4.24.23
EC:3.4.24.24
EC:3.4.24.3
EC:3.4.24.34
EC:3.4.24.35
EC:3.4.24.37
EC:3.4.24.55
EC:3.4.24.56
EC:3.4.24.57
EC:3.4.24.59
EC:3.4.24.61
EC:3.4.24.65
EC:3.4.24.69
EC:3.4.24.7
EC:3.4.24.70
EC:3.4.24.71
EC:3.4.24.72
MetaCyc:3.4.24.11-RXN
MetaCyc:3.4.24.14-RXN
MetaCyc:3.4.24.17-RXN
MetaCyc:3.4.24.18-RXN
MetaCyc:3.4.24.19-RXN
MetaCyc:3.4.24.21-RXN
MetaCyc:3.4.24.22-RXN
MetaCyc:3.4.24.23-RXN
MetaCyc:3.4.24.24-RXN
MetaCyc:3.4.24.35-RXN
MetaCyc:3.4.24.37-RXN
MetaCyc:3.4.24.55-RXN
MetaCyc:3.4.24.56-RXN
MetaCyc:3.4.24.57-RXN
MetaCyc:3.4.24.59-RXN
MetaCyc:3.4.24.61-RXN
MetaCyc:3.4.24.64-RXN
MetaCyc:3.4.24.69-RXN
MetaCyc:3.4.24.70-RXN
MetaCyc:3.4.24.71-RXN
MetaCyc:3.4.24.72-RXN
Reactome:R-HSA-1168777 "Metalloprotease cleavage of GHR"
Reactome:R-HSA-1251992 "Cleavage of P-ERBB4jmA isoforms by ADAM17"
Reactome:R-HSA-1299476 "MPP cleaves targeting peptide (presequence) of inner membrane precursors"
Reactome:R-HSA-1299478 "MPP cleaves targeting peptide (presequence) of matrix precursors"
Reactome:R-HSA-1454757 "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13"
Reactome:R-HSA-1454822 "Collagen type I degradation by MMP1,2,8,13, PRSS2"
Reactome:R-HSA-1458433 "Collagen type I degradation by MMP14"
Reactome:R-HSA-1474196 "Collagen type II degradation by MMP14"
Reactome:R-HSA-1474210 "Collagen type III degradation by MMP14"
Reactome:R-HSA-1474213 "Collagen type III degradation by MMP1,8,9,13"
Reactome:R-HSA-1564112 "Collagen type VI degradation by MMP2,9,11"
Reactome:R-HSA-1564117 "Collagen type XIV degradation by MMP9,13"
Reactome:R-HSA-1564120 "Collagen type VII degradation by MMP1,2,3"
Reactome:R-HSA-1564142 "Collagen type IV degradation by MMP2,3,4,9,10,12"
Reactome:R-HSA-1564143 "Collagen type X degradation by MMP1,2"
Reactome:R-HSA-1564164 "Collagen type V degradation by MMP2,9,10"
Reactome:R-HSA-1564169 "Collagen type VIII degradation by MMP1"
Reactome:R-HSA-1564179 "Collagen type XI degradation by MMP1,2,3,9"
Reactome:R-HSA-1564184 "Collagen type IX degradation by MMP3,13"
Reactome:R-HSA-1592310 "Aggrecan degradation by ADAMTSs"
Reactome:R-HSA-1655851 "S2P hydrolyzes SREBP1A,1C,2"
Reactome:R-HSA-177946 "Pro-EGF is cleaved to form mature EGF"
Reactome:R-HSA-181567 "botC LC cleaves target cell STX1"
Reactome:R-HSA-194793 "botC LC cleaves target cell SNAP25"
Reactome:R-HSA-194796 "botB LC cleaves target cell VAMP2"
Reactome:R-HSA-194800 "botE LC cleaves target cell SNAP25"
Reactome:R-HSA-194808 "botF LC cleaves target cell VAMP1"
Reactome:R-HSA-194809 "botD LC cleaves target cell VAMP1"
Reactome:R-HSA-194818 "botA LC cleaves target cell SNAP25"
Reactome:R-HSA-2002428 "Removal of fibrillar collagen N-propeptides"
Reactome:R-HSA-2002440 "Removal of fibrillar collagen C-propeptides"
Reactome:R-HSA-2022141 "Prolysyl oxidase activation"
Reactome:R-HSA-2168046 "Collagen type XII degradation by MMP12"
Reactome:R-HSA-2168982 "Collagen type XVI degradation by MMP9"
Reactome:R-HSA-2179402 "Active MMP3 can cleave pro-HBEGF to form active HBEGF"
Reactome:R-HSA-2473584 "Collagen type III degradation by MMP15"
Reactome:R-HSA-2473594 "Collagen type II degradation by MMP15"
Reactome:R-HSA-2473596 "Collagen type I degradation by MMP15"
Reactome:R-HSA-2484882 "Collagen type X degradation by MMP3, 13"
Reactome:R-HSA-2485111 "Collagen type III degradation by MMP10"
Reactome:R-HSA-2485148 "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13"
Reactome:R-HSA-2514790 "Elastin degradation by MMP14"
Reactome:R-HSA-2514831 "Fibrillin-1 degradation by MMP14"
Reactome:R-HSA-2533874 "Laminin-511 degradation by MMP14"
Reactome:R-HSA-2533944 "Fibronectin degradation by MMP10"
Reactome:R-HSA-2533950 "Fibronectin degradation by MMP14"
Reactome:R-HSA-2533965 "NID1 degradation by MMP14, MMP15"
Reactome:R-HSA-2533970 "NID1 degradation by MMP3, 7"
Reactome:R-HSA-2534240 "HSPG2 (perlecan) degradation by MMP14, MMP15"
Reactome:R-HSA-2534248 "DCN (decorin) degradation by MMP2, MMP3, MMP7"
Reactome:R-HSA-2537499 "Gelatin degradation by MMP19"
Reactome:R-HSA-264758 "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1"
Reactome:R-HSA-3371385 "TNF- is cleaved by ADAM17 (TACE)"
Reactome:R-HSA-3788075 "Brevican degradation by ADAMTS4, ADAMTS5"
Reactome:R-HSA-3791149 "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19"
Reactome:R-HSA-3791155 "Laminin-322 degradation by MMP14"
Reactome:R-HSA-3791295 "Aggrecan degradation by MMP1,2,3,7,9,12,13"
Reactome:R-HSA-3791319 "NID1 degradation by MMP19"
Reactome:R-HSA-381435 "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS"
Reactome:R-HSA-381518 "PAAP-A proteolyzes IGF:IGFBP4"
Reactome:R-HSA-381537 "PAPP-A2 proteolyzes IGF:IGFBP5:ALS"
Reactome:R-HSA-3827958 "E-cadherin degradation by MMP9, KLK7"
Reactome:R-HSA-3828025 "DCN (decorin) degradation by MMP14"
Reactome:R-HSA-4086205 "OPN (osteopontin) degradation by MMP3, MMP7"
Reactome:R-HSA-420818 "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)"
Reactome:R-HSA-4224014 "E-cadherin degradation by ADAM10, ADAM15"
Reactome:R-HSA-5228578 "tetX LC cleaves target cell VAMP2"
Reactome:R-HSA-5250606 "botD LC cleaves target cell VAMP2"
Reactome:R-HSA-5250892 "botF LC cleaves target cell VAMP2"
Reactome:R-HSA-5250962 "botG LC cleaves target cell VAMP2"
Reactome:R-HSA-5250978 "botG LC cleaves target cell VAMP1"
Reactome:R-HSA-5333671 "CLCAs self cleave"
Reactome:R-HSA-5362793 "Hh-Np is cleaved by ADAM17 to promote ligand shedding"
Reactome:R-HSA-5694082 "XK:KEL:Zn2+ cleaves EDN3"
Reactome:R-HSA-6784620 "MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461)"
Reactome:R-HSA-8867344 "OMA1 hydrolyses OPA1"
Reactome:R-HSA-8874122 "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta)"
Reactome:R-HSA-8874187 "MBTPS2 (S2P) cleaves CREB3L2"
Reactome:R-HSA-8874192 "MBTPS2 (S2P) cleaves CREB3"
Reactome:R-HSA-8874194 "MBTPS2 (S2P) cleaves CREB3L1"
Reactome:R-HSA-8874195 "MBTPS2 (S2P) cleaves CREB3L4"
Reactome:R-HSA-8874201 "MBTPS2 (S2P) cleaves CREB3L3"
Reactome:R-HSA-8876868 "ECE1 cleaves EDN1(53-90)"
Reactome:R-HSA-8877620 "ECE2 cleaves EDN1(53-90)"
Reactome:R-HSA-8940554 "MMP2 cleaves OPTC"
Reactome:R-HSA-8940561 "MMP7 cleaves OPTC"
Reactome:R-HSA-8940641 "THOP1 cleaves oligopeptide fragment (8-16aa)"
Reactome:R-HSA-8940959 "Neurolysin degrades neurotensin"
Reactome:R-HSA-8942302 "MMP13 cleaves OPTC"
Reactome:R-HSA-8943959 "MMP2, MMP9 cleave SCUBE3"
Reactome:R-HSA-8949649 "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)"
Reactome:R-HSA-8949659 "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU"
Reactome:R-HSA-8949668 "YME1L1 proteolyzes unassembled proSMDT1"
Reactome:R-HSA-9624272 "MMPs cleave HB-EGF"
Reactome:R-HSA-9822532 "ADAMTS13 cleaves VWF multimer"
Reactome:R-HSA-9824402 "ADAMTS13 variant does not cleave VWF multimer"
Reactome:R-HSA-9840408 "OMA1 cleaves DELE1"
Reactome:R-HSA-9840532 "OMA1 self-cleaves"
Reactome:R-HSA-9840564 "OMA1 hydrolyzes YME1L1"
Reactome:R-HSA-9844241 "ADAMTS13 cleaves VWF variant multimer"