FlyBase Gene Report: Dmel\Ptp69D

General Information

Symbol

Dmel\Ptp69D

Species

D. melanogaster

Name

Protein tyrosine phosphatase 69D

Annotation Symbol

CG10975

Feature Type

protein_coding_gene

FlyBase ID

FBgn0014007

Gene Model Status

Current

Stock Availability

41 publicly available

Enzyme Name (EC)

protein-tyrosine-phosphatase (3.1.3.48)

Gene Summary

Protein tyrosine phosphatase 69D (Ptp69D) encodes a transmembrane receptor tyrosine phosphatase (RPTP). It genetically interacts with the other RPTP genes and its mutants have embryonic motor axon guidance phenotypes. In particular, Ptp10D-Ptp69D double mutants have a strong phenotype in which embryonic CNS axons abnormally cross the ventral midline. The product of Ptp69D physically and genetically interacts with the product of Dscam1 to regulate arborization of mechanosensory neurons. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

DPTP69D, DPTP

Key Links

Genomic Location

Cytogenetic map

69D6-69E1

Sequence location

3L:12,734,945..12,741,568 [+]

Recombination map

3-39

RefSeq locus

NT_037436 REGION:12734945..12741568

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables transmembrane receptor protein tyrosine phosphatase activity

inferred from direct assay

(Streuli et al., 1989)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables protein tyrosine phosphatase activity

inferred from biological aspect of ancestor with PANTHER:PTN008567661

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR000242

(InterPro Project Members, 2004-)

Biological Process (8 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in axon guidance

inferred from genetic interaction with FLYBASE:sas; FB:FBgn0002306

(Lee et al., 2013)

inferred from genetic interaction with FLYBASE:Ptp10D; FB:FBgn0004370

(Lee et al., 2013)

involved_in defasciculation of motor neuron axon

inferred from mutant phenotype

(Desai et al., 1996)

inferred from genetic interaction with FLYBASE:Ptp99A; FB:FBgn0004369

(Desai et al., 1996)

involved_in dendrite morphogenesis

inferred from mutant phenotype

(Grueber et al., 2007)

involved_in fasciculation of sensory neuron axon

inferred from mutant phenotype

(Grueber et al., 2007)

involved_in motor neuron axon guidance

inferred from genetic interaction with FLYBASE:Ptp4E; FB:FBgn0004368,FLYBASE:Ptp10D; FB:FBgn0004370

(Jeon et al., 2008)

inferred from genetic interaction with FLYBASE:Ptp10D; FB:FBgn0004370

(Sun et al., 2001)

inferred from mutant phenotype

(Desai et al., 1996)

inferred from genetic interaction with FLYBASE:Ptp99A; FB:FBgn0004369

(Desai et al., 1996)

involved_in synaptic target inhibition

inferred from mutant phenotype

(Oliva et al., 2016)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in neuron projection development

inferred from biological aspect of ancestor with PANTHER:PTN000439254

(GO Reference Genome Project, 2011-)

involved_in signal transduction

inferred from biological aspect of ancestor with PANTHER:PTN008567661

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

located_in axon

inferred from direct assay

(Jeon et al., 2008)

located_in cell surface

inferred from direct assay

(Tong et al., 2011)

located_in plasma membrane

inferred from high throughput direct assay

(Lye et al., 2014, Tan et al., 2009)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

RECEPTOR PROTEIN TYROSINE PHOSPHATASES

Protein Family (UniProt)

Belongs to the protein-tyrosine phosphatase family. Receptor class subfamily. (P16620)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

protein tyrosine phosphatase activity

O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate (3.1.3.48)

RHEA 10684:

Summaries

Gene Snapshot

Gene Group (FlyBase)

RECEPTOR PROTEIN TYROSINE PHOSPHATASES -: Receptor Protein Tyrosine Phosphatases possess a single transmembrane domain and are localized to the plasma membrane. The Protein Tyrosine Phosphatases are defined by the active-site signature motif Cys-X5-Arg. (Adapted from FBrf0129980 and PMID:17057753).

Protein Function (UniProtKB)

Possible cell adhesion receptor.

(UniProt, P16620)

Summary (Interactive Fly)

receptor tyrosine phosphatase involved in axon guidance - Ptp10D-Ptp69D double mutants have a strong phenotype in which embryonic CNS axons abnormally cross the ventral midline - Ptp69D physically and genetically interacts with Dscam1 to regulate arborization of mechanosensory neurons

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Ptp69D for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P16620)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Ptp69D-RA

FBtr0075913

NM_079324

5168

1462

Ptp69D-RB

FBtr0075914

NM_176324

5165

1461

Additional Transcript Data and Comments

Reported size (kB)

4.477 (longest cDNA)

(Streuli et al., 1989)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Ptp69D-PA

FBpp0075645

167.5

1462

6.55

FBpp0075646

167.4

1461

6.55

NP_788502

AAO41254

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

1462 (aa)

(Streuli et al., 1989)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

P16620

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ptp69D using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ptp69D_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.63

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

central brain primordium

(Fisher et al., 2012)

embryonic central brain glial cell

(Fisher et al., 2012)

larval lateral VNC glial cell

(Fisher et al., 2012)

lateral cord neuron

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

larval nervous system

(Fisher et al., 2012)

larval lateral VNC glial cell

(Fisher et al., 2012)

lateral cord neuron

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

lamina plexus

(Garrity et al., 1999)

medulla anlage

(Garrity et al., 1999)

third instar larval stage

lamina plexus | anterior

(Garrity et al., 1999)

lamina anlage

(Garrity et al., 1999)

medulla anlage

(Garrity et al., 1999)

embryonic/larval optic lobe

(Garrity et al., 1999)

pupal stage P6

lamina

• cell surface

(Tong et al., 2011)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Ptp69D protein labels the cell surface of lamina cells in pupa.

(Tong et al., 2011)

In the third instar larval brain, Ptp69D is detected in the lamina plexus between the epithelial and marginal glia, and along the anterior edge of the lamina plexus where newly arriving R1-R6 axons terminate.

(Garrity et al., 1999)

Marker for

cell surface

(Tong et al., 2011)

Subcellular Localization

CV Term

Evidence

References

located_in axon

inferred from direct assay

(Jeon et al., 2008)

located_in cell surface

inferred from direct assay

(Tong et al., 2011)

located_in plasma membrane

inferred from high throughput direct assay

(Lye et al., 2014, Tan et al., 2009)

Expression Deduced from Reporters

Reporter: PBac{602.P.SVS-1}Ptp69D^CPTI000720

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain cell body rind | faint

(Knowles-Barley, 2011.8.24)

adult brain | ubiquitous

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Ptp69D in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ptp69D

View exonic expression by tissue for Dmel\Ptp69D

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0014007

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39443/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0014007

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0014007

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0014007

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10975

Flygut - An atlas of the Drosophila adult midgut

FBgn0014007

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Ptp69D

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 40 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 41 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ptp69D

Transgenic constructs containing regulatory region of Ptp69D

Aberrations (Deficiencies and Duplications) ( 6 )

Inferred from experimentation ( 6 )

Gene disrupted in

Df(3L)8ex25

(Desai et al., 1997)

Df(3L)BSC10

(Deal and Cook, 2002.1.4)

Df(3L)BSC381

(Christensen et al., 2007.10.29)

Df(3L)BSC413

(Christensen et al., 2008.4.15)

Df(3L)BSC730

(Christensen et al., 2009.2.28)

Df(3L)Exel6117

(Ryder, 2004.4.26)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^elav.PLu

lethal (with Df(3L)8ex34)

lethal (with Ptp69D¹)

lethal (with Ptp69D⁴)

lethal (with Ptp69D⁵)

lethal (with Ptp69D⁶)

lethal (with Ptp69D⁷)

lethal (with Ptp69D⁸)

lethal (with Ptp69D^8ex25)

lethal (with Ptp69D⁹)

lethal (with Ptp69D¹¹)

lethal (with Ptp69D¹³)

lethal (with Ptp69D¹⁴)

lethal (with Ptp69D¹⁵)

lethal (with Ptp69D¹⁶)

lethal (with Ptp69D¹⁷)

lethal (with Ptp69D¹⁹)

lethal (with Ptp69D²¹)

lethal (with Ptp69D²²)

lethal (with Ptp69D^D1515)

lethal (with Ptp69D^D1689)

lethal (with Ptp69D^H24)

lethal | heat sensitive (with Df(3L)8ex34)

lethal | heat sensitive (with Ptp69D¹)

lethal | heat sensitive (with Ptp69D⁴)

lethal | heat sensitive (with Ptp69D^8ex25)

lethal | heat sensitive (with Ptp69D¹²)

lethal | heat sensitive (with Ptp69D¹⁸)

lethal | recessive

lethal | recessive | heat sensitive

lethal - all die before end of pupal stage | heat sensitive

Ptp69D^10A1

partially lethal | heat sensitive (with Df(3L)8ex34)

partially lethal | heat sensitive (with Ptp69D¹)

partially lethal | heat sensitive (with Ptp69D⁴)

partially lethal | heat sensitive (with Ptp69D^8ex25)

partially lethal | heat sensitive (with Ptp69D¹⁰)

partially lethal | heat sensitive (with Ptp69D²⁰)

partially lethal | recessive

Ptp69D⁵

viable

Ptp69D²⁰

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

Sterility

Allele

female semi-sterile, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

Ptp69D^HMS01839

Other Phenotypes

Allele

abnormal body color, with Scer\GAL4^pnr-MD237

Ptp69D^GD2577

abnormal neuroanatomy

abnormal neuroanatomy (with Df(3L)8ex34)

Ptp69D¹

abnormal neuroanatomy | adult stage, with Scer\GAL4^Pdf.PU

abnormal neuroanatomy | adult stage, with Scer\GAL4^pnr-MD237

abnormal neuroanatomy | adult stage (with Ptp69D¹)

Ptp69D¹⁰

abnormal neuroanatomy | adult stage (with Ptp69D¹⁰)

Ptp69D¹

abnormal neuroanatomy | adult stage | cell autonomous, with Scer\GAL4^Or10a.PF

Ptp69D^HMS01839

abnormal neuroanatomy | larval stage

Ptp69D¹⁸

abnormal neuroanatomy | larval stage, with Scer\GAL4^ey-OK107

abnormal neuroanatomy | somatic clone | third instar larval stage

abnormal neuroanatomy | third instar larval stage (with Df(3L)8ex25)

Ptp69D¹

abnormal neuroanatomy | third instar larval stage (with Df(3L)8ex34)

Ptp69D^CRISPR.14

abnormal planar polarity, with Scer\GAL4^pnr-MD237

Ptp69D^GD81

abnormal size | adult stage, with Scer\GAL4^Pdf.PU

decreased size | adult stage, with Scer\GAL4^pnr-MD237

decreased size | adult stage (with Ptp69D¹)

Ptp69D¹⁰

decreased size | adult stage (with Ptp69D¹⁰)

Ptp69D¹

some die during larval stage (with Df(3L)8ex25)

Ptp69D¹

some die during pupal stage | heat sensitive

Ptp69D^10A1

visible, with Scer\GAL4^pnr-MD237

Ptp69D^GD14427

wild-type

Phenotype manifest in

Allele

adult olfactory receptor neuron | cell autonomous, with Scer\GAL4^Or10a.PF

Ptp69D^HMS01839

adult s-LNv neuron | adult stage, with Scer\GAL4^Pdf.PU

adult thoracic mechanosensory chaeta neuron, with Scer\GAL4^pnr-MD237

adult thoracic mechanosensory chaeta neuron (with Ptp69D¹)

Ptp69D¹⁰

adult thoracic mechanosensory chaeta neuron (with Ptp69D¹⁰)

Ptp69D¹

antennal lobe glomerulus VA7m | cell autonomous, with Scer\GAL4^Or10a.PF

Ptp69D^HMS01839

axon

Ptp69D¹⁰³⁶³

axon | adult stage, with Scer\GAL4^Pdf.PU

axon | adult stage | cell autonomous, with Scer\GAL4^Or10a.PF

Ptp69D^HMS01839

axon | larval stage

Ptp69D¹⁸

axon | larval stage, with Scer\GAL4^ey-OK107

axon | somatic clone | third instar larval stage

Ptp69D^D1689

axon collateral | adult stage, with Scer\GAL4^pnr-MD237

axon collateral | adult stage (with Ptp69D¹)

Ptp69D¹⁰

axon collateral | adult stage (with Ptp69D¹⁰)

Ptp69D¹

axon terminus | adult stage | decreased number, with Scer\GAL4^pnr-MD237

axon terminus | adult stage | decreased number (with Ptp69D¹)

Ptp69D¹⁰

axon terminus | adult stage | decreased number (with Ptp69D¹⁰)

Ptp69D¹

central nervous system

chaeta | increased number, with Scer\GAL4^pnr-MD237

Ptp69D^GD14427

dendrite

Ptp69D¹⁰³⁶³

dendritic arborizing neuron

Ptp69D¹⁰³⁶³

dendritic tree | somatic clone | third instar larval stage

dendritic tree | third instar larval stage (with Df(3L)8ex34)

Ptp69D^CRISPR.14

distal dendrite | third instar larval stage (with Df(3L)8ex34)

Ptp69D^CRISPR.14

embryonic/larval mushroom body | larval stage

Ptp69D¹⁸

embryonic/larval mushroom body | larval stage, with Scer\GAL4^ey-OK107

embryonic/larval mushroom body | third instar larval stage (with Df(3L)8ex25)

Ptp69D¹

glial cell & lamina

Ptp69D^unspecified

lamina plexus

Ptp69D^unspecified

larval abdominal segmental nerve (with Df(3L)8ex34)

Ptp69D¹

larval brain | third instar larval stage (with Df(3L)8ex25)

Ptp69D¹

larval intersegmental nerve

larval intersegmental nerve (with Df(3L)8ex34)

Ptp69D¹

larval multidendritic class IV neuron | somatic clone | third instar larval stage

larval multidendritic class IV neuron | third instar larval stage (with Df(3L)8ex34)

Ptp69D^CRISPR.14

larval RP5 motor neuron (with Df(3L)8ex25)

Ptp69D¹

larval VL3/4 motor neuron (with Df(3L)8ex25)

Ptp69D¹

larval VO1 motor neuron (with Df(3L)8ex25)

Ptp69D¹

larval VO2 motor neuron (with Df(3L)8ex25)

Ptp69D¹

lobe system of larval mushroom body, with Scer\GAL4^ey-OK107

Ptp69D^GD2577

medial lobe of larval mushroom body, with Scer\GAL4^ey-OK107

Ptp69D^{DA1DA2.UAS.Tag:MYC}

medial lobe of larval mushroom body | absent | somatic clone | third instar larval stage

Ptp69D^D1689

medulla

Ptp69D^unspecified

medulla | somatic clone

mesonotum, with Scer\GAL4^pnr-MD237

Ptp69D^GD2577

pedunculus of larval mushroom body

Ptp69D¹⁸

pedunculus of larval mushroom body, with Scer\GAL4^ey-OK107

photoreceptor cell & axon | somatic clone

photoreceptor cell R1 & axon

Ptp69D^unspecified

photoreceptor cell R1 & axon | somatic clone

photoreceptor cell R2 & axon

Ptp69D^unspecified

photoreceptor cell R2 & axon | somatic clone

photoreceptor cell R3 & axon

Ptp69D^unspecified

photoreceptor cell R3 & axon | somatic clone

photoreceptor cell R4 & axon

Ptp69D^unspecified

photoreceptor cell R4 & axon | somatic clone

photoreceptor cell R5 & axon

Ptp69D^unspecified

photoreceptor cell R5 & axon | somatic clone

photoreceptor cell R6 & axon

Ptp69D^unspecified

photoreceptor cell R6 & axon | somatic clone

photoreceptor cell R7 & axon | somatic clone

presynapse | adult stage | decreased number, with Scer\GAL4^pnr-MD237

presynapse | adult stage | decreased number (with Ptp69D¹)

Ptp69D¹⁰

presynapse | adult stage | decreased number (with Ptp69D¹⁰)

Ptp69D¹

RP neuron & axon

spur of larval mushroom body, with Scer\GAL4^ey-OK107

Ptp69D^{DA1DA2.UAS.Tag:MYC}

spur of larval mushroom body | somatic clone | third instar larval stage

Ptp69D^D1689

vertical lobe of larval mushroom body, with Scer\GAL4^ey-OK107

Ptp69D^{DA1DA2.UAS.Tag:MYC}

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (45)

Hsap\PTPRC

2 of 14

Yes

Hsap\PTPRD

2 of 14

Yes

Hsap\PTPRE

2 of 14

Yes

Hsap\PTPRF

2 of 14

Yes

Hsap\PTPRG

2 of 14

Yes

Hsap\PTPRK

2 of 14

Yes

Hsap\PTPRM

2 of 14

Yes

Hsap\PTPRT

2 of 14

Yes

Hsap\PTPRU

2 of 14

Yes

Hsap\PTPRZ1

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (34)

Rnor\Ptpra

2 of 14

Yes

Rnor\Ptprc

2 of 14

Yes

Rnor\Ptpre

2 of 14

Yes

Rnor\Ptprf

2 of 14

Yes

Rnor\Ptprg

2 of 14

Yes

Rnor\Ptprk

2 of 14

Yes

Rnor\Ptprm

2 of 14

Yes

Rnor\Ptprs

2 of 14

Yes

Rnor\Ptprt

2 of 14

Yes

Rnor\Ptpru

2 of 14

Yes

Rnor\Ptprz1

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (35)

Mmus\Ptpra

2 of 14

Yes

Mmus\Ptprc

2 of 14

Yes

Mmus\Ptprd

2 of 14

Yes

Mmus\Ptpre

2 of 14

Yes

Mmus\Ptprf

2 of 14

Yes

Mmus\Ptprg

2 of 14

Yes

Mmus\Ptprk

2 of 14

Yes

Mmus\Ptprm

2 of 14

Yes

Mmus\Ptprq

2 of 14

Yes

Mmus\Ptprs

2 of 14

Yes

Mmus\Ptprt

2 of 14

Yes

Mmus\Ptpru

2 of 14

Yes

Mmus\Ptprz1

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (15)

Xtro\ptprz1

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (39)

Drer\ca16b

2 of 14

Yes

Drer\ptprc

2 of 14

Yes

Drer\ptprea

2 of 14

Yes

Drer\ptprfb

2 of 14

Yes

Drer\ptprga

2 of 14

Yes

Drer\ptprsa

2 of 14

Yes

Drer\ptprua

2 of 14

Yes

Drer\ptprz1a

2 of 14

Yes

Drer\ptprz1b

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\ptpn18

1 of 14

Drer\ptpn21

1 of 14

Drer\ptpn22

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (77)

Cele\clr-1

7 of 14

Yes

Cele\F55H12.5

2 of 14

Yes

Cele\ptp-4

2 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\C55B7.3

1 of 14

Cele\dep-1

1 of 14

Cele\dig-1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\F57H12.5

1 of 14

Cele\hpo-7

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\Y22D7AR.7

1 of 14

Yes

Cele\Y39A3A.4

1 of 14

Cele\Y39B6A.30

1 of 14

Cele\Y48G1C.5

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (20)

Agam\AgaP_AGAP003187

12 of 12

Yes

Agam\AgaP_AGAP012901

5 of 12

Yes

3 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (1)

Atha\PTP1

3 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\PTP1

3 of 13

Yes

Scer\PTP3

1 of 13

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\pyp3

3 of 12

Yes

Spom\pyp2

2 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Ptp69D. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (20)

Lar

6 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

4 of 13

4 of 13

3 of 13

3 of 13

csw

2 of 13

Pez

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

fra

1 of 13

sdk

1 of 13

Wsck

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

PTPRC; protein tyrosine phosphatase receptor type C

model of severe combined immunodeficiency 105

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

Ptp69D¹

exacerbates muscular dystrophy-dystroglycanopathy

modeled by tw¹

(Monagas-Valentin et al., 2023)

Ptp69D^JF03399

ameliorates C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

modeled by Zzzz\GGGGCC^30.UAS.EGFP

(Pun et al., 2022)

exacerbates muscular dystrophy-dystroglycanopathy

modeled by tw^GD1160

(Monagas-Valentin et al., 2023)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

Ptp69D - msi

anti tag coimmunoprecipitation, quantitative reverse transcription pcr, anti bait coimmunoprecipitation

(Landínez-Macías et al., 2021)

protein-protein

Physical Interaction

Assay

References

Ptp69D

anti tag coimmunoprecipitation, anti tag western blot

(Garrity et al., 1999)

Ptp69D - Abl

enzymatic study, autoradiography

(Wills et al., 1999)

Ptp69D - Dscam1

anti tag coimmunoprecipitation, western blot

(Dascenco et al., 2015)

Ptp69D - Hmg-2

two hybrid

(Bugga et al., 2009)

Ptp69D - ena

pull down, western blot

(Wills et al., 1999)

Ptp69D - robo3

anti tag coimmunoprecipitation, anti tag western blot

(Oliva et al., 2016)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Ptp69D

suppressible

Lar::Ptp69D

(Maurel-Zaffran et al., 2001)

Ptp69D

suppressible

Lar

(Maurel-Zaffran et al., 2001)

Ptp69D

enhanceable

Ptp52F

(Schindelholz et al., 2001)

Ptp69D

enhanceable

Ptp99A

(Desai et al., 1996)

Ptp69D

suppressible

Ptp99A

(Desai and Purdy, 2003)

enhanceable

(Sun et al., 2000)

enhanceable

(Poe et al., 2017)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Sun et al., 2000)

suppressible

(Harrison et al., 2021)

enhanceable

(Poe et al., 2017)

suppressible

(Landínez-Macías et al., 2021)

msi

enhanceable

Ptp69D

(Landínez-Macías et al., 2021)

Ptp52F

enhanceable

Ptp69D

(Schindelholz et al., 2001)

robo2

enhanceable

Ptp69D

(Oliva et al., 2016)

robo2

suppressible

Ptp69D

(Oliva et al., 2016)

robo3

suppressible

Ptp69D

(Oliva et al., 2016)

enhanceable

(Lee et al., 2013)

enhanceable

(Poe et al., 2017)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

64791

DroID - A comprehensive database of gene and protein interactions.

FBgn0014007

MIST (genetic) - An integrated Molecular Interaction Database

39443

MIST (protein-protein) - An integrated Molecular Interaction Database

39443

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-39

Cytogenetic map

69D6-69E1

Sequence location

3L:12,734,945..12,741,568 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

69D6-69E1

Limits computationally determined from genome sequence between P{PZ}l(3)05088⁰⁵⁰⁸⁸ and P{PZ}l(3)06924⁰⁶⁹²⁴

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-39

(FlyBase, 2016)

3-33.2

(Comeron et al., 2012)

Left of (cM)

Diap1

(Desai and Purdy, 2003)

Right of (cM)

(Desai and Purdy, 2003)

Notes

Stocks and Reagents

Stocks (41)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

64138

P{UAS-Ptp69D.DA1}1, w^*

8488

w¹¹¹⁸; Ptp69D²⁰

64139

P{UAS-Ptp69D.DA1DA2}1, w^*

54766

w¹¹¹⁸; P{GMR29C02-lexA}attP40

64137

y¹ w^*; P{UAS-Ptp69D.DA1}2

29462

y¹ v¹; P{TRiP.JF03399}attP2

80893

y¹, v¹; P{TKO.GS04797}attP40

64135

y¹ w^*; P{UAS-Ptp69D.myc}2/CyO

81921

w^*; PBac{U6:3-Ptp4E-Ptp69D.gRNA}VK00027

81922

w^*; PBac{U6:3-Ptp10D-Ptp69D.gRNA}VK00027

VDRC

v104761

P{KK105220}VIE-260B

v27090

w¹¹¹⁸; P{GD14427}v27090

More stocks available...

Genomic Clones (18)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (63)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE06719

Other clones

RT02603

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0014007

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0014007

Antibody Information

Laboratory Generated Antibodies

monoclonal

(Garrity et al., 1999)

Commercially Available Antibodies

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

3F11

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Ptp69D is required for correct targeting of R7 axons.

(Newsome et al., 2000)

Ptp10D and Ptp69D are necessary for repulsion of growth cones from the midline of the embryonic central nervous system.

(Sun et al., 2000)

The phosphatase and FN3 domains of Ptp69D are required for R1-R6 targeting.

(Garrity et al., 1999)

Ptp69D is required, though not sufficient for targeting of R1-R6 axons to the lamina.

(Garrity et al., 1999)

In Ptp69D mutants R1-R6 project through the lamina, terminating in the medulla.

(Garrity et al., 1999)

Requirements of Lar, Ptp69D and Ptp99A in growth cone guidance decisions along the ISN and SNb motor pathways demonstrates relationships among the tyrosine phosphatases are complex and dependent on cellular context. At growth cone choice points along one nerve, two phosphatases cooperate, while along another nerve these same phosphatases can act in opposition to one another. Lar is central to ISN guidance, Ptp69D and Ptp99A are not essential but do participate in guidance processes involving Lar.

(Desai et al., 1997)

The products of the Ptp69D and Ptp99A genes are required for motor axon guidance and have partially redundant functions during development of the neuromuscular junction.

(Desai et al., 1996)

Ptp69D is a member of a family of receptor linked protein tyrosine phosphatases.

(Streuli et al., 1989)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (22)

Reported As

Symbol Synonym

69D

(Lee et al., 2013)

CG10975

(Christis and Munro, 2012, Khanna et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Schiess et al., 2009, Berger et al., 2008, Morrison et al., 2000)

CT30751

(Hynes and Zhao, 2000)

DPTP

(Halaby and Mornon, 1998, Chiba and Keshishian, 1996, Sells and Chernoff, 1995, Oon et al., 1993, Tian et al., 1991)

Dptp69D

(Jeong, 2021, Bateman and Van Vactor, 2001)

PTP69D

(Kawakami et al., 2022, Bali et al., 2019, Lee and Godenschwege, 2015, Cameron et al., 2013, Tong et al., 2011, Song et al., 2008, Bazigou et al., 2007, Hofmeyer et al., 2007, Morey et al., 2005, Andersen et al., 2004, Rao et al., 2002, Chiba, 2001, Newsome et al., 1999)

PTPase

(Hynes and Zhao, 2000)

Ptp

Ptp69D

(Bischoff et al., 2025, Huang et al., 2024, Titlow et al., 2023, Pun et al., 2022, Bilder et al., 2021, Landínez-Macías et al., 2021, Ostalé et al., 2021, Hall et al., 2019, Poe et al., 2019, Williamson and Vale, 2018, Hakeda-Suzuki et al., 2017, Poe et al., 2017, Transgenic RNAi Project members, 2017-, Shen et al., 2016, Hatzihristidis et al., 2015, Pogson et al., 2014, Sopko et al., 2014, Carter, 2013, Kwon et al., 2013, Lee et al., 2013, Ozkan et al., 2013, Sen et al., 2013, Hadjieconomou et al., 2011, Weng et al., 2011, Wasbrough et al., 2010, Wright et al., 2010, Bugga et al., 2009, Christensen et al., 2009.2.28, Hofmeyer and Treisman, 2009, Tan et al., 2009, Berger et al., 2008, Christensen et al., 2008.4.15, Jeon et al., 2008, Kurusu and Zinn, 2008, Christensen et al., 2007.10.29, Dietzl et al., 2007, Xing et al., 2007, Rehwinkel et al., 2005, Sun et al., 2001)

Ptp69d

(Bakal et al., 2008, Tayler and Garrity, 2003)

R-PTP 69D

(Morrison et al., 2000)

RPTP69D

(Sanhueza et al., 2025)

RPtp69D

(Dascenco et al., 2015)

dptp69D

(Ackley and Jin, 2004, Landgraf et al., 1999, Netter et al., 1998, Garrity et al., 1997, Desai et al., 1996, Stoker, 1996)

dptp69d

(Babu et al., 2005)

ptp69

(Harrison et al., 2021)

ptp69D

(Weng et al., 2011, Berger et al., 2008, Grueber et al., 2007, Newsome et al., 1999)

ptp69d

(Mattila et al., 2008)

rptp69d

(Oliva et al., 2016)

Name Synonyms

Protein tyrosine phosphatase 69D

(Khanna et al., 2010, Xing et al., 2007)

protein tyrosine phosphatase PTP69D

(Song et al., 2008)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 52 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39443

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P16620

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P16620

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P16620

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0014007

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39443/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0014007

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0014007

FlyMine - An integrated database for Drosophila genomics

FBgn0014007

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG10975

MARRVEL_MODEL - MARRVEL (model organism gene)

39443

Linkouts

BioGRID - A database of protein and genetic interactions.

64791

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0014007

DroID - A comprehensive database of gene and protein interactions.

FBgn0014007

DRSC - Results frm RNAi screens

FBgn0014007

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

3F11

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ptp69D_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0014007

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0014007

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10975

Flygut - An atlas of the Drosophila adult midgut

FBgn0014007

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC004289

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

39443

MIST (protein-protein) - An integrated Molecular Interaction Database

39443

References (196)

The following external sites may use different assemblies or annotations than FlyBase.

-0.63

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