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FB2026_01
,
released March 12, 2026
naked
EF-hand calcium-binding domain protein involved in Wingless pathway - targets dishevelled to antagonize Wnt signal transduction
Please see the JBrowse view of Dmel\nkd for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.45
Multiphase exon postulated: exon reading frame differs in alternative transcripts; overlap >20aa.
5.0 (northern blot)
None of the polypeptides share 100% sequence identity.
928 (aa); 102 (kD predicted)
Interacts with dsh. This interaction may be stabilized by zinc.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\nkd using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: anlage in statu nascendi
Comment: reported as head epidermis primordium
Comment: reported as head epidermis primordium
Comment: reported as head epidermis primordium
nkd RNA is not detected in 0-2hr embryo RNA. It is detected in 2-4hr RNA, peaks in 4-8hr RNA and then declines. By in situ hybridization, nkd transcripts are observed in broad anterior and posterior domains reminiscent of a gap gene pattern in the late cellular blastoderm. During germ band extension, nkd transcription is nearly ubiquitous with higher levels in the 2-3 rows posterior to the hh/en stripe. During full germ band extension, nkd transcript levels are highest just anterior to and lower just posterior to the hh/en stripe. The level is even lower in the hh/en-producing cells. After stage 10, wg and nkd are co-expressed in many tissues. They are expressed in overlapping patterns in imaginal discs and other larval tissues where the nkd domain is slightly broader than the wg domain.
nkd protein is detected in a segmentally repeated cytoplasmic pattern very similar to the mRNA distribution pattern.
JBrowse - Visual display of RNA-Seq signals
View Dmel\nkd in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Segment polarity gene expression is necessary for the survival of specific rows of epidermal cells.
Wild type activity of five segment polarity genes, wg, ptc, en, nkd and hh, can account for most of the ventral pattern elements in the embryo. wg is required for naked cuticle and en is required for the first row of denticles in each abdominal denticle belt. Remaining cell types are produced by different combinations of the five gene activities. wg generates the diversity of cell types within the segment but each specific cell identity depends on the activity of ptc, en, nkd and hh. ptc and nkd may affect wg autoregulation, and restrict wg activity within the segment.
Dfd expression unaffected by mutations at this locus.
Mutations in zygotic polarity gene nkd do not interact with RpII140wimp.
nkd mutants display deleted denticle belts.
Source for merge of: nkd CG18224 CG11614
Release 1 annotation CG18224 corresponds to part of the release 3.2 annotation for nkd (CG11614).
