FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\nkdΔhis
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General Information
Symbol
Dmel\nkdΔhis
Species
D. melanogaster
Name
FlyBase ID
FBal0363931
Feature type
allele
Associated gene
Dmel\nkd
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Gammons et al., 2020)
Mutagen
CRISPR/Cas9
(Gammons et al., 2020)
Progenitor genotype
Cytology
Description

Deletion of base pairs 1916-1926 resulting in a frameshift at P639 and a truncation at codon 677.

(Mieszczanek and Bienz, 2021.2.9)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:19,005,784..19,005,794 [-]
Comment:

Deletion of base pairs 1916-1926 of the nkd-RA CDS resulting in a frameshift at codon P639 of nkd-PA and a truncation at codon 677.

(Mieszczanek and Bienz, 2021.2.9)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      nkdΔhis/nkdΔhis embryos exhibit several abnormal denticle belts with disordered denticle rows, misoriented denticles as well as excess small denticles in their anterior regions.

      nkdΔhis/nkd13 transheterozygous embryos exhibit defective denticle belts.

      (Gammons et al., 2020)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      nkdDeltahis
      (Mieszczanek and Bienz, 2021.2.9)
      nkdΔhis
      (Gammons et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)