FB2026_03 , released September 17, 2026
Aberration: Dmel\In(2LR)SM5
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General Information
Symbol
In(2LR)SM5
Species
D. melanogaster
Name
FlyBase ID
FBab0004817
Feature type
chromosomal_inversion
Computed Cytological Breakpoints (relative to progenitor)

21D2-21D3;29C-29E;36C;40F;42D;53C;58F

Sequenced Breakpoints (relative to progenitor)
Member of large scale dataset(s)
Nature of Aberration
Cytological Order

2Lt - 21D2 | 36C - 40F | 29C - 22D2 | 34A1 - 36C | 21D3 - 22A3 | 60B - 58B1 | 42A3 - 42D | 42D - 42A3 | 58B1 - 58F | 53C - 42D | 53C - 58A4 | 42A2 - 40F | 29E - 33F5 | 22D1 - 22B1 | 60C - 2Rt

Progenitor
In(2L)SM5-1
(Miller et al., 2018)
In(2L)SM5-2
(Miller et al., 2018)
Dp(2;2)SM5
(Miller et al., 2018)
Mutagen
X ray
Class of aberration (relative to wild type)
chromosomal_inversion
Class of aberration (relative to progenitor)
Cytological Breakpoints (relative to progenitor)
Causes alleles
ds55
(Clark et al., 1995, Craymer, 1980)
Carries alleles
Transposon Insertions
Formalized genetic data

bk1 hits ds

Genetic mapping information
Comments
Comments on Cytology

All limits from polytene analysis (citation unavailable)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
ds
(Craymer, 1980)
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Complementation Data
 
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (0)
    If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
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    Phenotypic Data
    In combination with other aberrations

    Df(2L)TW50/SM5 shows reduced viability: only 4% of expected progeny survive. Ddc1/SM5 also shows reduced viability: only 24% of expected progeny survive.

    (Wright et al., 1976)

    In(2LR)SM5/M(2)58F lethal(C. Hinton); probably related to break in 58F.

    NOT in combination with other aberrations

    Homozygous lethal. Heterozygote usually has good viability and fertility, although may not be as good as SM1.

    (Lindsley and Zimm, 1992)
    Stocks (0)
    Notes on Origin
    Discoverer

    Craymer.

    (Craymer, 1980)

    R.F. Grell, 1955.

     

    Irradiation of SM1 resulted in transpositions and additional inversions on the SM1 chromosome. Two regions are duplicated on the chromosome: 2R:6 ,012,459-6,916,8092 (predicted cytology 42A7-42E1) and 2R:21 ,972,072-22,689,962 (predicted cytology 58A4-59A2). The distal duplicated segment allows deficiencies for the haploinsufficient gene RpS24 to be maintained as simple balanced stocks (FBrf0205398).

    (Parks and Cook, 2026.8.6)

    SM5 arose from SM1 through two inversions (In(2L)SM5-1 followed by In(2L)SM5-2) and a complex rearrangement - the symbol Dp(2;2)SM5 was chosen for the complex rearrangement to emphasize the duplicated segment from the progenitor over the inverted segment.

    (Miller et al., 2018)
    Balancer / Genotype Variants of the Aberration
    Separable Components
     
    Other Comments
     
    Synonyms and Secondary IDs (4)
    Reported As
    Symbol Synonym
    Dp(2;2)SM5
    In(2LR)SM5
    SM5
    (Parks and Cook, 2026.8.6)
    Name Synonyms
    Duplication(2;2)Second Multiple
    Secondary FlyBase IDs
    • FBab0010278
    • FBab0003503
    References (21)