FlyBase Allele Report: Dmel\ds[1]

General Information

Symbol

Dmel\ds¹

Species

D. melanogaster

Name

FlyBase ID

FBal0003119

Feature type

allele

Associated gene

Dmel\ds

Associated Insertion(s)

412{}ds¹

Carried in Construct

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

(Clark et al., 1995)

Progenitor genotype

Associated Insertion(s)

412{}ds¹

Cytology

Description

7.6kb insertion of the 412 element within the region encoding the eleventh cadherin domain very close to the 3' end of the fifth exon. Analysis of cDNAs reveals that the wild type splice donor of the fifth intron is inactivated by the insertion. As a result three cryptic splice donor sites are uncovered, two upstream of and close to the 412 and a third site 30bp within the 412 element. The result is that two out of three of these variants encode a product which is deleted for just 23 amino acids of the eleventh cadherin domain.

(Clark et al., 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage

(Revilla-Yates et al., 2015)

visible

(Revilla-Yates et al., 2015)

visible | recessive

(Clark et al., 1995)

Phenotype Manifest In

anterior crossvein

(Clark et al., 1995)

axon & larval optic lobe

(Dearborn and Kunes, 2004)

eye

(Clark et al., 1995)

glial cell & larval optic lobe

(Dearborn and Kunes, 2004)

leg

(Clark et al., 1995)

leg (with ds^38k)

(Rodriguez, 2004)

leg (with ds⁰⁵¹⁴²)

(Rodriguez, 2004)

leg joint (with ds^38k)

(Rodriguez, 2004)

leg joint (with ds⁰⁵¹⁴²)

(Rodriguez, 2004)

tarsal segment (with ds^38k)

(Rodriguez, 2004)

tarsal segment (with ds⁰⁵¹⁴²)

(Rodriguez, 2004)

thorax

(Clark et al., 1995)

wing

(Revilla-Yates et al., 2015, Clark et al., 1995)

wing | proximal

(Adler et al., 1998)

wing hair

(Revilla-Yates et al., 2015, Adler et al., 1998)

wing vein

(Revilla-Yates et al., 2015)

Detailed Description

Statement

Reference

The wings of ds¹ homozygote adults are slightly smaller and rounder than in controls, and have vein and hair patterning defects.

(Revilla-Yates et al., 2015)

Scaffold axons project aberrantly in the larval optic lobes if ds¹ mutants. Glia line these aberrant pathways and accumulate in abnormal destinations such as the lobula cortex.

(Dearborn and Kunes, 2004)

ds⁰⁵¹⁴²/ds¹ and ds^38k/ds¹ flies have legs with reduced segment size and fusion of the tarsal segments and partial elimination of the tarsal joints.

(Rodriguez, 2004)

Approximately half the wings of either ds^UAO71/ds¹ or ds^33k/ds¹ flies have a very weak tissue polarity phenotype, consisting of a couple of multiple hair cells and/or a small region of polarity disruption in the proximal part of the wing.

(Adler et al., 1998)

Viable allele. In addition to 100% penetrant defects in leg, wing and thorax, rough patches in the eye appear at low frequency. Anterior crossvein is displaced posteriorly.

(Clark et al., 1995)

ds^38k/ds¹ flies have an extreme ds phenotype.

(Curry, 1939)

Wings shorter, blunter and broader; crossveins uniformly very close together. Abdomen and legs chunky. Slight dominance of close crossveins. Stronger alleles may exhibit enhanced dominance, reduced viability, female sterility, delayed emergence, widely spaced scutellar bristles and erect costal bristles. Strong interaction with d, fj and cg; double homozygotes often have excessive growth of thoracic parts and sometimes conversion of one organ into another (e.g., hypertrophy of notum, duplication of wings and antennae and transformations of tarsus to arista, eye to antenna or palpus, or wing to notum (Waddington, 1943; Waddington, 1962). Tarsal shortening enhanced by homozygous ss^a and ss^aB (Villee, 1945). RK1.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

ds¹/ds^UAO71 has abnormal planar polarity phenotype, enhanceable by fj^d1/fj^d1

(Strutt et al., 2004)

Enhancer of

Statement

Reference

ds¹/ds^UAO71 is an enhancer of abnormal planar polarity phenotype of fj^d1

(Strutt et al., 2004)

NOT Enhancer of

Statement

Reference

ds¹/ds[+] is a non-enhancer of visible | dominant phenotype of sog^EP11

(Araujo et al., 2003)

ds¹/ds[+] is a non-enhancer of visible | dominant phenotype of sog^EP7

(Araujo et al., 2003)

NOT Suppressor of

Statement

Reference

ds¹/ds[+] is a non-suppressor of visible | dominant phenotype of sog^EP11

(Araujo et al., 2003)

ds¹/ds[+] is a non-suppressor of visible | dominant phenotype of sog^EP7

(Araujo et al., 2003)

Other

Statement

Reference

ds¹/ds^UAO71, fj^d1 has abnormal planar polarity phenotype

(Strutt et al., 2004)

Phenotype Manifest In

Enhanced by

Statement

Reference

ds¹/ds⁰⁵¹⁴² has leg joint phenotype, enhanceable by dsh³/dsh[+]

(Rodriguez, 2004)

ds¹/ds⁰⁵¹⁴² has leg phenotype, enhanceable by dsh³/dsh[+]

(Rodriguez, 2004)

ds¹/ds⁰⁵¹⁴² has tarsal segment phenotype, enhanceable by dsh³/dsh[+]

(Rodriguez, 2004)

ds¹/ds^UAO71 has wing phenotype, enhanceable by fj^d1/fj^d1

(Strutt et al., 2004)

Suppressed by

Statement

Reference

ds¹/ds^38k has leg joint phenotype, suppressible by nkd²/nkd[+]

(Rodriguez, 2004)

ds¹/ds^38k has tarsal segment phenotype, suppressible | partially by nkd²/nkd[+]

(Rodriguez, 2004)

ds¹/ds^38k has leg phenotype, suppressible | partially by nkd²/nkd[+]

(Rodriguez, 2004)

Enhancer of

Statement

Reference

ds¹/ds[+] is an enhancer of wing phenotype of fj^d1

(Strutt et al., 2004)

ds¹/ds^UAO71 is an enhancer of wing phenotype of fj^d1

(Strutt et al., 2004)

ds¹/ds[+] is an enhancer of crossvein phenotype of fj^d1

(Strutt et al., 2004)

ds^33k/ds¹ is an enhancer of phenotype of fz²⁴

(Adler et al., 1998)

ds¹ is an enhancer of phenotype of fz²⁴

(Adler et al., 1998)

ds^33k/ds¹ is an enhancer of phenotype of fz^unspecified

(Adler et al., 1998)

ds¹ is an enhancer of phenotype of Alu¹

NOT Enhancer of

Statement

Reference

ds¹/ds[+] is a non-enhancer of wing vein phenotype of sog^EP11

(Araujo et al., 2003)

ds¹/ds[+] is a non-enhancer of wing vein phenotype of sog^EP7

(Araujo et al., 2003)

NOT Suppressor of

Statement

Reference

ds¹/ds[+] is a non-suppressor of wing vein phenotype of sog^EP11

(Araujo et al., 2003)

ds¹/ds[+] is a non-suppressor of wing vein phenotype of sog^EP7

(Araujo et al., 2003)

Other

Statement

Reference

ds¹/ds^UAO71, fj^d1 has ommatidium phenotype

(Strutt et al., 2004)

ds¹/ds^UAO71, fj^d1 has wing hair phenotype

(Strutt et al., 2004)

ds¹/ds^UAO71, fj^d1 has posterior crossvein phenotype

(Strutt et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

nkd²/+ partially suppresses the leg phenotype of ds^38k/ds¹ flies: tarsal joint formation is completely rescued and the size of the tarsal segments is recovered almost to that of wild type. dsh³/+ enhances the severity of leg phenotypes in ds⁰⁵¹⁴²/ds¹ animals: The length of the segments is reduced and most of the tarsal joints very reduced or completely absent.

(Rodriguez, 2004)

Unlike either single mutant, 'fj^d1 ds¹/fj^d1 ds^UAO71' flies completely lack a posterior crossvein and have defects in wing hair polarity. 16% of ommatidia in these double mutants are inverted compared to less than 1% in either single mutant. The wing shortening phenotype of fj^d1 homozygotes is also enhanced by ds¹/+. Like ds^38k/ds^UAO71 flies, ds^38k/ds^UAO71; fj^{109-583.Scer\UAS.T:Hsap\GALNT3} ; Scer\GAL4^bi-omb-Gal4 flies have inverted ommatidia scattered throughout their eyes.