FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\dsΔICD.UAS
Open Close
General Information
Symbol
Dmel\dsΔICD.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0193594
Feature type
allele
Associated gene
Dmel\ds
Associated Insertion(s)
Carried in Construct
P{UAS-ds.ΔICD}
Also Known As
UAS-dsΔICD
Key Links
Transgenic product class
inframe_deletion
(Matakatsu and Blair, 2006)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Matakatsu and Blair, 2006)
Mutagen
in vitro construct
(Matakatsu and Blair, 2006)
Progenitor genotype
dsUAS.cTa
(Matakatsu and Blair, 2006)
Carried in construct
P{UAS-ds.ΔICD}
Cytology
Description

UASt regulatory sequences drive expression of ds amino acid residues 1-3134, producing a truncated protein that lacks the regions with high homology to the intracellular domains of vertebrate dachsous 1 and 2.

(Matakatsu and Blair, 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
ds
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of dsΔICD.Scer\UAS in the wing causes hairs to orient away from the region of misexpression when driven by Scer\GAL4salm-459.2, Scer\GAL4Dll-md23 or Scer\GAL4en-e16E.

      Wings that express dsΔICD.Scer\UAS under the control of Scer\GAL4αTub84B.PL causes a foreshortening along the proximodistal axis of the wing blade as the anterior and posterior crossveins are abnormally close.

      (Matakatsu and Blair, 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      S2 cells that express ftScer\UAS.cMa and dsΔICD.Scer\UAS, under the control of Scer\GAL4Act5C.PI, aggregate.

      (Matakatsu and Blair, 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      dsΔICD.UAS/Scer\GAL4ds-gal4 partially rescues ds05142

      (Matakatsu and Blair, 2006)

      dsΔICD.UAS/Scer\GAL4αTub84B.PL partially rescues ds05142

      (Matakatsu and Blair, 2006)
      Comments

      Expression of dsΔICD.Scer\UAS, under the control of Scer\GAL4αTub84B.PL, rescues the planar cell polarity defects of ds05142 wings in all areas except the most proximal regions of the wing blade. Expression driven by Scer\GAL4ds-gal4 partially rescues planar cell polarity in the proximal wing.

      (Matakatsu and Blair, 2006)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Carried in a plasmid and transfected into S2 cells for use in cell aggregation assays.

      (Matakatsu and Blair, 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      dsΔICD.Scer\UAS
      dsΔICD.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (4)