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Citation
Geisbrecht, E.R., Montell, D.J. (2004). A role for Drosophila IAP1-mediated caspase inhibition in Rac-dependent cell migration.  Cell 118(1): 111--125.
FlyBase ID
FBrf0179220
Publication Type
Research paper
Abstract

Border cell migration in the Drosophila ovary is a relatively simple and genetically tractable model for studying the conversion of epithelial cells to migratory cells. Like many cell migrations, border cell migration is inhibited by a dominant-negative form of the GTPase Rac. To identify new genes that function in Rac-dependent cell motility, we screened for genes that when overexpressed suppressed the migration defect caused by dominant-negative Rac. Overexpression of the Drosophila inhibitor of apoptosis 1 (DIAP1), which is encoded by the thread (th) gene, suppressed the migration defect. Moreover, loss-of-function mutations in th caused migration defects but, surprisingly, did not cause apoptosis. Mutations affecting the Dark protein, an activator of the upstream caspase Dronc, also rescued RacN17 migration defects. These results indicate an apoptosis-independent role for DIAP1-mediated Dronc inhibition in Rac-mediated cell motility.

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Note

Migrate, differentiate, proliferate, or die: pleiotropic functions of an apical 'apoptotic caspase'.
Kumar, 2004, Sci. STKE 2004(254): pe49 [FBrf0180674]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference