FlyBase Allele Report: Dmel\Dronc[CARD.UAS]

General Information

Symbol

Dmel\Dronc^CARD.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0104747

Feature type

allele

Associated gene

Dmel\Dronc

Associated Insertion(s)

Carried in Construct

P{UAS-dronc-CARD}

Also Known As

UAS-dronc^CARD, UAS-Dronc-CARD

Key Links

Transgenic product class

inframe_deletion

(Meier, 2000.4.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Meier, 2000.4.5)

Mutagen

in vitro construct

(Meier, 2000.4.5)

Progenitor genotype

Carried in construct

P{UAS-dronc-CARD}

Cytology

Description

The Dronc prodomain sequences alone (nucleotides 369-786) are expressed under the control of UASt sequences.

(Meier, 2000.4.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Dronc

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

The addition of Nc^{CARD.Scer\UAS} driven by Scer\GAL4^GMR.PF, to rpr^GMR.PW embryos completely suppresses cell killing in the eye.

(Meier et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Dronc^CARD.UAS, Scer\GAL4^GMR.PU is a suppressor of visible phenotype of DCAF12^UAS.cHa, Scer\GAL4^GMR.PU

(Hwangbo et al., 2016)

Scer\GAL4^en.PU/Dronc^CARD.UAS is a suppressor | partially of cell lethal | somatic clone phenotype of RpS3^Plac92

(Kale et al., 2015)

Scer\GAL4^sca-537.4/Dronc^CARD.UAS is a suppressor | partially of visible phenotype of Rala^35d

(Balakireva et al., 2006)

Dronc^CARD.UAS, Scer\GAL4^GMR.PF is a suppressor of increased cell death phenotype of Scer\GAL4^GMR.PF, egr^UAS.cMa

(Moreno et al., 2002)

NOT Suppressor of

Statement

Reference

Scer\GAL4^en.PU/Dronc^CARD.UAS is a non-suppressor of increased cell death | somatic clone phenotype of RpS3^Plac92

(Kale et al., 2015)

Phenotype Manifest In

Suppressor of

Statement

Reference

Dronc^CARD.UAS, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of DCAF12^UAS.cHa, Scer\GAL4^GMR.PU

(Hwangbo et al., 2016)

Scer\GAL4^sca-537.4/Dronc^CARD.UAS is a suppressor | partially of microchaeta phenotype of Rala^35d

(Balakireva et al., 2006)

Scer\GAL4^sca-537.4/Dronc^CARD.UAS is a suppressor of macrochaeta phenotype of Rala^35d

(Balakireva et al., 2006)

Dronc^CARD.UAS, Scer\GAL4^slbo.2.6 is a suppressor | partially of border follicle cell phenotype of Rac1^N17.UAS, Scer\GAL4^slbo.2.6

(Geisbrecht and Montell, 2004)

Dronc^CARD.UAS, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, egr^UAS.cMa

(Moreno et al., 2002)

Scer\GAL4^GMR.PF/Dronc^CARD.UAS is a suppressor of phenotype of rpr^GMR.PW

(Meier et al., 2000)

NOT Suppressor of

Statement

Reference

Scer\GAL4^T80/Dronc^CARD.UAS is a non-suppressor of wing disc | somatic clone phenotype of Myc⁴

(Neto-Silva et al., 2010)

yki^UAS.cHa, Scer\GAL4^T80, Dronc^CARD.UAS is a non-suppressor of wing disc | somatic clone phenotype of Myc⁴

(Neto-Silva et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Dronc^{CARD.Scer\UAS} suppresses eye phenotypes in flies with expression of DCAF12^Scer\UAS.cHa driven by Scer\GAL4^GMR.PU.

(Hwangbo et al., 2016)

Cell death is similar in the posterior compartment expressing Dronc^{CARD.Scer\UAS} (via Scer\GAL4^en.PU) to the control anterior compartment in RpS3^Plac92/+ wing discs in which wild type clones have been induced. However, some homozygous RpS3^Plac92 cell clones are observed.

(Kale et al., 2015)

Expression of Nc^{CARD.Scer\UAS} under the control of Scer\GAL4^T80 in dm⁴ mutant wing disc clones does not rescue clone size.

Expression of yki^Scer\UAS.cHa and Nc^{CARD.Scer\UAS} under the control of Scer\GAL4^T80 in dm⁴ mutant wing disc clones does not rescue clone size.

(Neto-Silva et al., 2010)

The border follicle cell migration defect seen in egg chambers expressing Rac1^N17.Scer\UAS under the control of Scer\GAL4^slbo.2.6 is partially suppressed by coexpression of Nc^{CARD.Scer\UAS}.

(Geisbrecht and Montell, 2004)

The presence of Nc^{CARD.Scer\UAS} partially supresses the eye ablation phenotype seen in egr^Scer\UAS.cMa; Scer\GAL4^GMR.PF flies. This supression is dose dependent: 2 copies suppress more effectivley than 1.

(Moreno et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to rescue

Dronc^CARD.UAS fails to rescue Dronc^I29/Dronc^L32

(Napoletano et al., 2017)

Comments

The expression of Dronc^{CARD.Scer\UAS} under the control of Scer\GAL4^nos.PU fails to rescue either the significant proportion of hyperplastic adult testes and the increased necrosis at the apical tip of testes observed in Dronc^I29/Dronc^L32 transheterozygotes.

(Napoletano et al., 2017)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

DRONC^DN

(Balakireva et al., 2006)

Dronc^{CARD.Scer\UAS}

Dronc^CARD.UAS

Nc^{CARD.Scer\UAS}

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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