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Citation
Hwangbo, D.S., Biteau, B., Rath, S., Kim, J., Jasper, H. (2016). Control of apoptosis by Drosophila DCAF12.  Dev. Biol. 413(1): 50--59.
FlyBase ID
FBrf0232014
Publication Type
Research paper
Abstract

Regulated Apoptosis (Programmed Cell Death, PCD) maintains tissue homeostasis in adults, and ensures proper growth and morphogenesis of tissues during development of metazoans. Accordingly, defects in cellular processes triggering or executing apoptotic programs have been implicated in a variety of degenerative and neoplastic diseases. Here, we report the identification of DCAF12, an evolutionary conserved member of the WD40-motif repeat family of proteins, as a new regulator of apoptosis in Drosophila. We find that DCAF12 is required for Diap1 cleavage in response to pro-apoptotic signals, and is thus necessary and sufficient for RHG (Reaper, Hid, and Grim)-mediated apoptosis. Loss of DCAF12 perturbs the elimination of supernumerary or proliferation-impaired cells during development, and enhances tumor growth induced by loss of neoplastic tumor suppressors, highlighting the wide requirement for DCAF12 in PCD.

PubMed ID
PubMed Central ID
PMC5106244 (PMC) (EuropePMC)
Related Publication(s)
Personal communication to FlyBase

Location data for DCAF12[Delta1] excision deletion.
Hwangbo and Jasper, 2016.6.30, Location data for DCAF12[Delta1] excision deletion. [FBrf0232792]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Biol.
    Title
    Developmental Biology
    Publication Year
    1959-
    ISBN/ISSN
    0012-1606
    Data From Reference