FlyBase Allele Report: Dmel\Diap1[GMR.PH]

General Information

Symbol

Dmel\Diap1^GMR.PH

Species

D. melanogaster

Name

glass multimer reporter construct of Hay

FlyBase ID

FBal0050600

Feature type

allele

Associated gene

Dmel\Diap1

Associated Insertion(s)

Carried in Construct

P{GMR-DIAP1}

Also Known As

GMR-diap1

Key Links

Transgenic product class

cDNA

(Hay et al., 1995)

wild_type

(Hay et al., 1995)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Hay et al., 1995)

wild_type

(Hay et al., 1995)

Mutagen

in vitro construct

(Hay et al., 1995)

Progenitor genotype

Carried in construct

P{GMR-DIAP1}

Cytology

Description

GMR regulatory sequences drive expression of a Diap1 cDNA.

(Hay et al., 1995)

Allele components

Component

Use(s)

Regulatory region(s)

GMR

engineered transcription regulatory region

Encoded product / tool

Diap1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates tauopathy

modeled by Hsap\MAPT^GMR.Ex.PJ

(Jackson et al., 2002)

ameliorates Parkinson's disease

modeled by HtrA2^ΔPDZ.GMR

(Khan et al., 2008)

ameliorates cancer

modeled by Alk^UAS.cLa

(Wolfstetter et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

eye | P-stage

(Hay et al., 1995)

pigment cell

(Hay et al., 1995)

Detailed Description

Statement

Reference

Expression of th^GMR.PH does not cause retinal degeneration.

(Hsu et al., 2004)

Flies expressing th^GMR.PH have normal eye morphology.

(Yu et al., 2002)

Normally occurring cell death (35-50hr postpupation) is blocked in eye development, giving rise to extra cells. Also blocks a second wave of normally occurring cell death that takes place between 60 and 70 hrs postpupation.

(Hay et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Diap1^GMR.PH is a suppressor of visible phenotype of DCAF12^UAS.cHa, Scer\GAL4^GMR.PU

(Hwangbo et al., 2016)

Diap1^GMR.PH is a suppressor of abnormal neuroanatomy | progressive phenotype of YME1L^del

(Qi et al., 2016)

Diap1^GMR.PH is a suppressor of visible | heat sensitive phenotype of HtrA2^GMR.PK

(Khan et al., 2008)

Diap1^GMR.PH is a suppressor of visible phenotype of Rfx2^{202-480.UAS.Tag:HA}, Scer\GAL4^GMR.PS

(Otsuki et al., 2004)

Diap1^GMR.PH is a suppressor of visible phenotype of Scer\GAL4^GMR.APP, grim^UAS.cYa

(Guo et al., 2003)

Diap1^GMR.PH is a suppressor of visible phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Diap1^GMR.PH is a suppressor of increased cell death phenotype of Prx4^AKP.Ub.GMR

(Tenev et al., 2002)

Diap1^GMR.PH is a suppressor of visible phenotype of BacA\p35^GMR.PH

(Yu et al., 2002)

Diap1^GMR.PH is a suppressor of increased cell death phenotype of Dref^UAS.cSa, Scer\GAL4^GMR.PS

(Hirose et al., 2001)

Diap1^GMR.PH is a suppressor of abnormal eye color phenotype of Dronc^GMR.PH

(Hawkins et al., 2000)

Diap1^GMR.PH is a suppressor of visible phenotype of Dronc^GMR.PH

(Hawkins et al., 2000)

Diap1^GMR.PH is a suppressor of visible phenotype of Dronc^UAS.EGFP, Scer\GAL4^GMR.PF

(Quinn et al., 2000)

Diap1^GMR.PH is a suppressor of increased cell death phenotype of Fmr1^sev.PW

(Wan et al., 2000)

Diap1^GMR.PH is a suppressor of visible phenotype of Psn^+14.UAS, Scer\GAL4^GMR.PF

(Ye and Fortini, 1999)

Diap1^GMR.PH is a suppressor of abnormal cell death phenotype of hid^GMR.PG

(Hay et al., 1995)

Diap1^GMR.PH is a suppressor of abnormal cell death phenotype of rpr^GMR.PH

(Hay et al., 1995)

NOT Suppressor of

Statement

Reference

Diap1^GMR.PH is a non-suppressor of increased cell death phenotype of norpA^P24

(Hsu et al., 2004)

Phenotype Manifest In

Suppressor of

Statement

Reference

Diap1^GMR.PH is a suppressor of eye phenotype of DCAF12^UAS.cHa, Scer\GAL4^GMR.PU

(Hwangbo et al., 2016)

Diap1^GMR.PH is a suppressor of rhabdomere | progressive phenotype of YME1L^del

(Qi et al., 2016)

Diap1^GMR.PH is a suppressor of eye | heat sensitive phenotype of HtrA2^GMR.PK

(Khan et al., 2008)

Diap1^GMR.PH is a suppressor of eye phenotype of Rfx2^{202-480.UAS.Tag:HA}, Scer\GAL4^GMR.PS

(Otsuki et al., 2004)

Diap1^GMR.PH is a suppressor of eye phenotype of Scer\GAL4^GMR.APP, grim^UAS.cYa

(Guo et al., 2003)

Diap1^GMR.PH is a suppressor of eye phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Diap1^GMR.PH is a suppressor of ommatidium phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Diap1^GMR.PH is a suppressor of eye phenotype of rpr^GMR.PH

(Lohmann et al., 2002)

Diap1^GMR.PH is a suppressor of eye phenotype of Dfd^UAS.cLa, Scer\GAL4^GMR.PF

(Lohmann et al., 2002)

Diap1^GMR.PH is a suppressor of eye phenotype of Dfd^VP16.UAS, Scer\GAL4^GMR.PF

(Lohmann et al., 2002)

Diap1^GMR.PH is a suppressor of eye phenotype of Prx4^AKP.Ub.GMR

(Tenev et al., 2002)

Diap1^GMR.PH is a suppressor of eye phenotype of rpr^AKP.Ub.GMR

(Tenev et al., 2002)

Diap1^GMR.PH is a suppressor of eye phenotype of rpr^AVA.Ub.GMR

(Tenev et al., 2002)

Diap1^GMR.PH is a suppressor of ommatidium phenotype of BacA\p35^GMR.PH

(Yu et al., 2002)

Diap1^GMR.PH is a suppressor of eye phenotype of Dref^UAS.cSa, Scer\GAL4^GMR.PS

(Hirose et al., 2001)

Diap1^GMR.PH is a suppressor of eye phenotype of Dronc^GMR.PH

(Hawkins et al., 2000)

Diap1^GMR.PH is a suppressor of pigment cell phenotype of Dronc^GMR.PH

(Hawkins et al., 2000)

Diap1^GMR.PH is a suppressor of pigment cell phenotype of Dronc^pro.UAS, Scer\GAL4^GMR.PF

(Meier et al., 2000)

Diap1^GMR.PH is a suppressor of ommatidium phenotype of Dronc^pro.UAS, Scer\GAL4^GMR.PF

(Meier et al., 2000)

Diap1^GMR.PH is a suppressor of eye phenotype of Dronc^pro.UAS, Scer\GAL4^GMR.PF

(Meier et al., 2000)

Diap1^GMR.PH is a suppressor of eye phenotype of Dronc^ΔN.UAS, Scer\GAL4^GMR.PF

(Meier et al., 2000)

Diap1^GMR.PH is a suppressor of eye phenotype of Dronc^UAS.EGFP, Scer\GAL4^GMR.PF

(Quinn et al., 2000)

Diap1^GMR.PH is a suppressor of eye phenotype of Fmr1^sev.PW

(Wan et al., 2000)

Diap1^GMR.PH is a suppressor of ommatidium phenotype of Fmr1^sev.PW

(Wan et al., 2000)

Diap1^GMR.PH is a suppressor | partially of eye photoreceptor cell phenotype of Cele\ced-4^GMR.PK

(Kanuka et al., 1999)

Diap1^GMR.PH is a suppressor | partially of pigment cell phenotype of Cele\ced-4^GMR.PK

(Kanuka et al., 1999)

Diap1^GMR.PH is a suppressor | partially of eye phenotype of Cele\ced-4^GMR.PK

(Kanuka et al., 1999)

Diap1^GMR.PH is a suppressor of eye phenotype of Psn^+14.UAS, Scer\GAL4^GMR.PF

(Ye and Fortini, 1999)

Diap1^GMR.PH is a suppressor of eye phenotype of hid^Ala3.GMR

(Bergmann et al., 1998)

Diap1^GMR.PH is a suppressor of eye phenotype of hid^Ala5.GMR

(Bergmann et al., 1998)

Diap1^GMR.PH is a suppressor of eye phenotype of hid^GMR.PG

(Bergmann et al., 1998)

Diap1^GMR.PH is a suppressor of ommatidium phenotype of hid^GMR.PG

(Bergmann et al., 1998)

Diap1^GMR.PH is a suppressor of eye phenotype of aos^GMR.PS

(Sawamoto et al., 1998)

Diap1^GMR.PH is a suppressor of photoreceptor neuron phenotype of aos^GMR.PS

(Sawamoto et al., 1998)

Diap1^GMR.PH is a suppressor of pigment cell phenotype of aos^GMR.PS

(Sawamoto et al., 1998)

Diap1^GMR.PH is a suppressor of cone cell phenotype of aos^GMR.PS

(Sawamoto et al., 1998)

NOT Suppressor of

Statement

Reference

Diap1^GMR.PH is a non-suppressor of retina phenotype of norpA^P24

(Hsu et al., 2004)

Diap1^GMR.PH is a non-suppressor of pigment cell phenotype of Dronc^ΔN.UAS, Scer\GAL4^GMR.PF

(Meier et al., 2000)

Diap1^GMR.PH is a non-suppressor of ommatidium phenotype of Dronc^ΔN.UAS, Scer\GAL4^GMR.PF

(Meier et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Diap1^GMR.PH suppresses apoptotic eye phenotypes in flies with DCAF12^Scer\UAS.cHa driven by Scer\GAL4^GMR.PU.

(Hwangbo et al., 2016)

Diap1^GMR.PH suppresses the locomotor defect and age-dependent loss of rhabdomeres seen in YME1L^del homozygotes.

(Qi et al., 2016)

Co-expression of th^GMR.PH suppresses the eye ablation phenotype seen in animals in which HtrA2^GMR.PK has been expressed under heat-stress conditions (30[o]C for 5 days).

(Khan et al., 2008)

Expression of th^GMR.PH does not alter the degeneration of norpA³⁶ rhabdomeres.

(Hsu et al., 2004)

The enlarged eye phenotype seen in flies carrying one copy of upd1^GMR.PB is not modified by Diap1^GMR.PH.

(Bach et al., 2003)

The small eye phenotype caused by expression of grim^Scer\UAS.cYa under the control of Scer\GAL4^{GMR.T:Hsap\APP} is completely suppressed by co-expression of th^GMR.PH.

(Guo et al., 2003)

The addition of th^GMR.PH suppresses the eye phenotype in Hsap\MAPT^GMR.Ex.PJ animals.

(Jackson et al., 2002)

When th^GMR.PH is added to Dfd^Scer\UAS.cLa, Scer\GAL4^GMR.PF animals the eye phenotype is almost completely suppressed. When th^GMR.PH is added to Dfd^{Scer\UAS.T:Hsim\VP16}, Scer\GAL4^GMR.PF animals the eye phenotype is suppressed. When th^GMR.PH is added to rpr^GMR.PH animals the eye phenotype is almost completely suppressed.

(Lohmann et al., 2002)

The rough eye phenotype of BacA\p35^GMR.PH animals is suppressed by th^GMR.PH. Flies expressing Nc^C318S.GMR and th^GMR.PH have normal eye morphology. Flies expressing Nc^GMR.PH and th^GMR.PH have normal eye morphology.

(Yu et al., 2002)

The rough eye phenotype seen upon expression of Dref^Scer\UAS.cSa in the developing eye under the control of Scer\GAL4^GMR.PS is suppressed by co-expression of th^GMR.PH.

(Hirose et al., 2001)

The small eye and pigment loss phenotypes of flies expressing high levels of Nc^GMR.PH is suppressed by co-expression of th^GMR.PH.

(Hawkins et al., 2000)

The addition of th^GMR.PH to Nc^pro.Scer\UAS,Scer\GAL4^GMR.PF completely rescues the phenotypes seen in these flies. The addition of th^GMR.PH to Nc^ΔN.Scer\UAS,Scer\GAL4^GMR.PF fails to rescue the phenotypes seen in these flies.

(Meier et al., 2000)

Largely suppresses the rough eye phenotype caused by expression of two copies of Psn^+14.Scer\UAS under the control of Scer\GAL4^GMR.PF.

(Ye and Fortini, 1999)

Suppresses the rough eye phenotype of argos^GMR.PS : normal number of cone cells and primary pigment cells are restored in most ommatidia.

(Sawamoto et al., 1998)

Xenogenetic Interactions

Statement

Reference

The rough eye phenotype caused by expression of Hsap\MAPT^{V337M.Scer\UAS} under the control of Scer\GAL4^GMR.PF is suppressed by co-expression of th^GMR.PH.

(Shulman and Feany, 2003)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

5782

w^*; P{GMR-DIAP1}1/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Diap1^GMR.PH

th^GMR.PH

Name Synonyms

glass multimer reporter construct of Hay

(Hay et al., 1995)

Secondary FlyBase IDs

References (28)

Report Sections

Open Close