FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\hidAla3.GMR
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General Information
Symbol
Dmel\hidAla3.GMR
Species
D. melanogaster
Name
FlyBase ID
FBal0093997
Feature type
allele
Associated gene
Dmel\hid
Associated Insertion(s)
Carried in Construct
P{GMR-hid.Ala3}
Key Links
Transgenic product class
missense_variant
(Bergmann et al., 1998)
polypeptide_post_translational_processing_variant
(Bergmann et al., 1998)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Bergmann et al., 1998)
polypeptide_post_translational_processing_variant
(Bergmann et al., 1998)
Mutagen
in vitro construct
(Bergmann et al., 1998)
Progenitor genotype
Carried in construct
P{GMR-hid.Ala3}
Cytology
Description

Three out of five phosphorylation sites mutated. Amino acid replacement: T148A. Amino acid replacement: T180A. Amino acid replacement: S251A. Expression is governed by GMR regulatory sequences.

(Bergmann et al., 1998)
Allele components
Component
Use(s)
Regulatory region(s)
GMR
Encoded product / tool
hid
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Eye reduced. Phenotypes of WGMR.PG, WAla3.GMR and WAla5.GMR are comparable. Some lines completely lack eye structures. Phenotype is slightly suppressed by hemizygosity at the endogenous W locus.

      (Bergmann et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      hidAla3.GMR has increased cell death phenotype, suppressible by Ras85DR68Q

      (Gafuik and Steller, 2011)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      hidAla3.GMR has eye phenotype, suppressible by Diap1GMR.PH

      (Bergmann et al., 1998)

      hidAla3.GMR has eye phenotype, suppressible by rlSem

      (Bergmann et al., 1998)
      NOT suppressed by
      Statement
      Reference

      hidAla3.GMR has phenotype, non-suppressible by Ras85DV12.sev

      (Bergmann et al., 1998)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Ras85DR68Q suppresses WAla3.GMR (which lacks 3 of the 5 predicted MAPK phosphorylation sites) induced cell death.

      (Gafuik and Steller, 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      WAla3.GMR
      hidAla3.GMR
      Name Synonyms
      Secondary FlyBase IDs
        References (2)