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General Information
Symbol
Dmel\DfdUAS.cLa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Li
FlyBase ID
FBal0094850
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Dfd
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of the entire Dfd open reading frame.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of DfdScer\UAS.cLa under the control of Scer\GAL4rn.PU suppresses wing formation.

Expression of DfdScer\UAS.cLa under the control of Scer\GAL4dpp.blk1 results in transformation of the arista to tarsus.

When DfdScer\UAS.cLa is driven by Scer\GAL4arm.PS the number of apoptotic cells seen in the embryonic head and abdominal segments increases substantially. When DfdScer\UAS.cLa is driven in the eye by Scer\GAL4GMR.PF a mild eye ablation phenotype is seen.

Embryos expressing DfdScer\UAS.cLa under the control of Scer\GAL4arm.PS have ectopic mouth hook fragments and cirri. When the Scer\GAL4arm.PS driver is provided paternally, development of these ectopic maxillary structures is restricted largely to the labial and thoracic segments. When the Scer\GAL4arm.PS driver is provided maternally, development of these ectopic maxillary structures occurs throughout the trunk, including the abdominal segments. The number and segment-specific features of the thoracic and abdominal cuticle develop nearly normally in both cases.

Strong DfdScer\UAS.cLa expression in the antenna disc driven by Scer\GAL4dpp.blk1 causes ingrowth of antennal disc tissue and produces adults with antennal third segments that are enlarged but not transformed into leg structures.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of pbScer\UAS.T:Avic\GFP-EGFP suppresses the arista-to-tarsus transformation seen in flies expressing DfdScer\UAS.cLa under the control of Scer\GAL4dpp.blk1.

When thGMR.PH is added to DfdScer\UAS.cLa, Scer\GAL4GMR.PF animals the eye phenotype is almost completely suppressed.

The addition of cncB.hs suppresses the rescuing effect seen by DfdScer\UAS.cLa (when driven by Scer\GAL4arm.PS) on Dfd16 mutants.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

When DfdScer\UAS.cLa driven by Scer\GAL4arm.PS is added to Dfd16 mutants, the maxillary mouth hooks and cirri are restored to near-normal morphology.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
DfdScer\UAS.cLa
DfdUAS.cLa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Li
Secondary FlyBase IDs
    References (11)