FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\HtrA2GMR.PK
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General Information
Symbol
Dmel\HtrA2GMR.PK
Species
D. melanogaster
Name
glass multimer reporter construct of Khan
FlyBase ID
FBal0240453
Feature type
allele
Associated gene
Dmel\HtrA2
Associated Insertion(s)
Carried in Construct
P{GMR-HtrA2.K}
Key Links
Transgenic product class
wild_type
(Khan et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Khan et al., 2008)
Mutagen
in vitro construct
(Khan et al., 2008)
Progenitor genotype
Carried in construct
P{GMR-HtrA2.K}
Cytology
Description

GMR regulatory sequences drive expression of full-length, wild-type HtrA2.

(Khan et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
GMR
Encoded product / tool
HtrA2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Two copies of HtrA2GMR.PK generally do not disrupt eye development at room temperature (14/19 lines tested).

      Expression of HtrA2GMR.PK in heat-stressed larvae (incubated at 30[o]C for 5 days) results in an eye ablation phenotype in newly eclosed adults.

      (Khan et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      HtrA2GMR.PK has visible | heat sensitive phenotype, suppressible by Diap1GMR.PH

      (Khan et al., 2008)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      HtrA2GMR.PK has eye | heat sensitive phenotype, suppressible by Diap1GMR.PH

      (Khan et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of thGMR.PH suppresses the eye ablation phenotype seen in animals in which HtrA2GMR.PK has been expressed under heat-stress conditions (30[o]C for 5 days).

      (Khan et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      HtrA2GMR.PK
      Name Synonyms
      glass multimer reporter construct of Khan
      Secondary FlyBase IDs
        References (1)