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General Information
Symbol
Dmel\hidAla5.GMR
Species
D. melanogaster
Name
FlyBase ID
FBal0093995
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
GMR-hidAla5
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Five out of five phosphorylation sites mutated. Amino acid replacement: S121A. Amino acid replacement: T148A. Amino acid replacement: T180A. Amino acid replacement: T228A. Amino acid replacement: S251A. Expression is governed by GMR regulatory sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

WAla5.GMR flies have a smaller eye than normal.

WAla5.GMR flies exhibit a small eye phenotype due to increased apoptosis in the eye.

Mutant animals have small rough eyes.

Eye reduced. Phenotypes of WGMR.PG, WAla3.GMR and WAla5.GMR are comparable. Some lines completely lack eye structures. Phenotype is slightly suppressed by hemizygosity at the endogenous W locus.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Suppressed by
NOT suppressed by
Statement
Reference

hidAla5.GMR has visible phenotype, non-suppressible by RasGAP1mip-w+/Gap1[+]

hidAla5.GMR has visible phenotype, non-suppressible by aos[+]/aosΔ7

Other
Phenotype Manifest In
Enhanced by
Statement
Reference

hidAla5.GMR has eye phenotype, enhanceable by mir-bftΔ263a

Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference

hidAla5.GMR has eye phenotype, non-suppressible by aos[+]/aosΔ7/AckK156A.UAS/Scer\GAL4GMR.PU

hidAla5.GMR has eye phenotype, non-suppressible by RasGAP1mip-w+/Gap1[+]

hidAla5.GMR has eye phenotype, non-suppressible by aos[+]/aosΔ7

hidAla5.GMR has phenotype, non-suppressible by Ras85DV12.sev

Additional Comments
Genetic Interactions
Statement
Reference

Heterozygosity for either Gap1mip-w+ or aosΔ7 does not suppress the small eye phenotype caused by WAla5.GMR.

Expression of AckK156A.Scer\UAS under the control of Scer\GAL4GMR.PU (either alone, or in conjunction with either aosΔ7/+ or Gap1mip-w+/+) does not suppress the small eye phenotype caused by WAla5.GMR.

Expression of AckScer\UAS.cSb under the control of Scer\GAL4GMR.PU suppresses the small eye phenotype caused by WAla5.GMR. Further suppression is seen if the flies are also heterozygous for either aosΔ7/+ or Gap1mip-w+/+.

Expression of AckScer\UAS.cSb under the control of Scer\GAL4GMR.PU suppresses the small eye phenotype caused by WAla5.GMR. Further suppression is seen if the flies are also co-expressing SH3PX1KK100618.

Co-expression of either Hsp26KK106347 or MagiGD10066 further reduces the size of the eye in a WAla5.GMR, AckScer\UAS.cSb, Scer\GAL4GMR.PU background.

Co-expression of drkKK109233 does not modify eye size in animals expressing WAla5.GMR.

Co-expression of drkKK109233 in a WAla5.GMR, AckScer\UAS.cSb, Scer\GAL4GMR.PU background results in flies with eyes that are greatly reduced in size.

Ras85DR68Q fails to suppress WAla5.GMR (which lacks all of the 5 predicted MAPK phosphorylation sites) induced cell death.

Expression of dcoScer\UAS.cSa in the eye (under the control of Scer\GAL4GMR.PF) strongly suppresses the pro-apoptotic activity of WAla5.GMR.

Eye size is largely restored by co-expression of banEP3622 (driven by Scer\GAL4GMR.PF) with WAla5.GMR. The addition of Df(3L)banΔ1 to WAla5.GMR animals leads to a significant enhancement of the eye phenotype.

When sav3 clones are induced in the eye disc in WAla5.GMR mutants, the induction of apoptosis is reduced in a cell autonomous manner.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
WAla5.GMR
hidAla5.GMR
Name Synonyms
Secondary FlyBase IDs
    References (8)