FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\HtrA2ΔPDZ.GMR
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General Information
Symbol
Dmel\HtrA2ΔPDZ.GMR
Species
D. melanogaster
Name
FlyBase ID
FBal0240454
Feature type
allele
Associated gene
Dmel\HtrA2
Associated Insertion(s)
Carried in Construct
P{GMR-HtrA2.ΔPDZ}
Key Links
Transgenic product class
inframe_deletion
(Khan et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Khan et al., 2008)
Mutagen
in vitro construct
(Khan et al., 2008)
Progenitor genotype
Carried in construct
P{GMR-HtrA2.ΔPDZ}
Cytology
Description

GMR regulatory sequences drive expression of a constitutively active form of HtrA2 (the PDZ domain is deleted).

(Khan et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
GMR
Encoded product / tool
HtrA2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Parkinson's disease
      CEA
      (Khan et al., 2008)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  Parkinson's disease
      is ameliorated by Diap1GMR.PH
      (Khan et al., 2008)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of HtrA2ΔPDZ.GMR generally results in eye ablation (25/31 lines tested).

      (Khan et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      HtrA2ΔPDZ.GMR
      Name Synonyms
      Secondary FlyBase IDs
        References (1)