FlyBase Allele Report: Dmel\pic[PL12c]

General Information

Symbol

Dmel\pic^PL12c

Species

D. melanogaster

Name

FlyBase ID

FBal0220978

Feature type

allele

Associated gene

Dmel\pic

Associated Insertion(s)

Carried in Construct

Also Known As

Ddb1^PL12c

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Hu et al., 2008)

Mutagen

P-element activity

(Hu et al., 2008)

Progenitor genotype

pic^EY01408

(Hu et al., 2008)

Cytology

Description

Excision of the insertion in pic^EY01408.

(Hu et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate (with pic²)

(Hu et al., 2008)

cell lethal | somatic clone

(Hwangbo et al., 2016)

partially lethal - majority die (with pic²)

(Hu et al., 2008)

visible (with pic²)

(Hu et al., 2008)

Phenotype Manifest In

eye | somatic clone

(Hwangbo et al., 2016)

macrochaeta (with pic²)

(Hu et al., 2008)

wing disc | somatic clone | third instar larval stage

(Hwangbo et al., 2016)

Detailed Description

Statement

Reference

pic^PL12c/pic^PL12c limits clonal growth in the eye or wing disc.

(Hwangbo et al., 2016)

pic²/pic^PL12c animals develop into viable adults, but these animals show a significant developmental delay and eclose on average 2 to 4 days later than control siblings at 25[o]C and 18[o]C respectively. The flies have cuticle defects including missing bristles and small bristles that resemble those of Minute mutants.

(Hu et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

pic^PL12c has cell lethal | somatic clone phenotype, suppressible by DCAF12^Δ1/DCAF12^Δ1

(Hwangbo et al., 2016)

pic^PL12c has cell lethal | somatic clone phenotype, suppressible by BacA\p35^UAS.cUa

(Hwangbo et al., 2016)

pic^PL12c/pic² has partially lethal - majority die phenotype, suppressible by gig[+]/gig¹⁹²

(Hu et al., 2008)

pic^PL12c/pic² has abnormal developmental rate phenotype, suppressible by gig[+]/gig¹⁹²

(Hu et al., 2008)

Phenotype Manifest In

Suppressed by

Statement

Reference

pic^PL12c has eye | somatic clone phenotype, suppressible by DCAF12^Δ1/DCAF12^Δ1

(Hwangbo et al., 2016)

pic^PL12c has wing disc | somatic clone | third instar larval stage phenotype, suppressible by DCAF12^Δ1/DCAF12^Δ1

(Hwangbo et al., 2016)

pic^PL12c has eye | somatic clone phenotype, suppressible by BacA\p35^UAS.cUa

(Hwangbo et al., 2016)

NOT suppressed by

Statement

Reference

pic^PL12c/pic² has macrochaeta phenotype, non-suppressible by gig[+]/gig¹⁹²

(Hu et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

DCAF12^Δ1/DCAF12^Δ1 suppresses the apoptotic phenotype (of limited clonal growth) in pic^PL12c/pic^PL12c eye clones or wing clones.

(Hwangbo et al., 2016)

Heterozygosity for gig¹⁹² substantially suppresses the late eclosion phenotype and the semi-lethality of pic²/pic^PL12c animals, but the bristle defects caused by pic²/pic^PL12c are not significantly suppressed by gig¹⁹²/+.

(Hu et al., 2008)

Xenogenetic Interactions

Statement

Reference

BacA\p35^Scer\UAS.cUa expression suppresses the apoptotic phenotype (of limited clonal growth) in pic^PL12c/pic^PL12c eye clones.

(Hwangbo et al., 2016)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Ddb1^PL12c

(Hu et al., 2008)

ddb1^PL12C

(Hwangbo et al., 2016)

pic^PL12c

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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