Vps43B1 suppresses the increase in photoreceptor number seen in shi7C7 mutant eye disc clones, with the double mutants showing the photoreceptor loss seen in Vps43B1 mutants alone. The same is seen in a DroncI29 mutant background.
Dcp-1Prev1; NcI29 double mutants exhibit an arrest of vCrz programmed cell death with all 16 vCrz neurons retained at 7 and 16 hours after puparium formation, compared to apoptosis of these neurons in wild-type controls.
Induction of NcI29 third instar larval eyes disc clones blocks the cell death seen when p53GUS.PB is expressed under the control of Scer\GAL4GMR.PU. However the reduction in R7 photoreceptors is not rescued.
Females containing dream4 ; NcI29 double homozygous germline clones are fertile, but their ovaries contain 46% of mid-stage egg chambers with missing follicle cells and large surviving nurse cells. Many of these egg chambers contain excessive numbers of nurse cells. There is also an increase in mid-stage egg chambers containing condensed nurse cell nuclei but lacking follicle cells. 21% of stage 14 egg chambers contain persisting nurse cell nuclei.
The persistence of salivary gland tissue that is seen at 24 hours hours after puparium formation when Pi3K92EScer\UAS.T:Hsap\MYC is expressed under the control of Scer\GAL4fkh.PH is significantly enhanced if the animals are also carrying NcI24/NcI29.
NcI29/+ suppresses the increase in the number of TUNEL-positive cells seen in the wing discs in larvae expressing Rcom\RAcs2.Scer\UAS under the control of Scer\GAL4en-e16E at 30[o]C. It also largely rescues the non-autonomous increase in BrdU incorporation which is seen in the non-expressing compartment in discs expressing Rcom\RAcs2.Scer\UAS under the control of Scer\GAL4en-e16E at 30[o]C. NcI29/+ does not rescue the autonomous or the non-autonomous reduction in wing area caused by expression of Rcom\RAcs2.Scer\UAS under the control of Scer\GAL4en-e16E.
Both the significant proportion of hyperplastic adult testes and the increased necrosis at the apical tip of the testes observed in DroncI29/DroncL32 transheterozygotes are rescued by the expression of Droncpro.Scer\UAS, Droncpro.C-A.Scer\UAS, DroncΔN.Scer\UAS, or DroncΔN.C-A.Scer\UAS, but not DroncCARD.Scer\UAS, under the control of Scer\GAL4nos.PU. The significant proportion of hyperplastic adult testes is also rescued by the expression of either DroncWT.5'3'UTR or DroncC-A.5'3'UTR.