FlyBase Allele Report: Dmel\Dcp-1[Prev1]

General Information

Symbol

Dmel\Dcp-1^Prev1

Species

D. melanogaster

Name

FlyBase ID

FBal0156746

Feature type

allele

Associated gene

Dmel\Dcp-1

Associated Insertion(s)

Carried in Construct

Also Known As

Dcp-1^Prev, dcp1^Prev1, dcp1^Prev

Key Links

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Laundrie et al., 2003)

Progenitor genotype

Dcp-1^k05606

(Laundrie et al., 2003)

Cytology

Description

Imprecise excision of P{lacW}Dcp-1^k05606 has left 40bp of P-element sequence at the insertion site leading to a frameshift in Dcp-1 and an in-frame stop codon within the 40-bp insertion.

(Laundrie et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Both Dcp-1^Prev1 homozygotes (in a cleaned-up background by recombination) and Dcp-1^k05606/Dcp-1^Prev1 transheterozygotes do not show protection against (injury-induced) Wallerian degeneration in third instar larval motoneurons.

(Hao et al., 2019)

Dcp-1^Prev1 homozygotes do not exhibit a significant proportion of hyperplastic testes, as compared to controls.

(Napoletano et al., 2017)

In Dcp-1^Prev1 mutant optic lobes, the peak number of apoptotic cells is unchanged as compared to wild-type, at 24h APF, but the decrease of number of apoptotic cells following the peak is slower. By 72h APF, however, the number of apoptotic cells is similar to wild-type. The spatial distribution of apoptotic cells is very similar to wild type between 0-36h APF, but there were apoptotic cells in some regions of the optic lobe at 48h that do not have apoptotic cells in wild type. Cell corpse clearance is normal between 0-24h APF and in late pupal stages, but is reduced throughout the optic lobe in areas of cell death at 36h APF.

(Akagawa et al., 2015)

After amino acid deprivation, degenerating midstage egg chambers from Dcp-1^Prev1 flies contain a reduction in the percentage of autolysosomes compared with controls. Non-degenerating midstage egg chambers from starved Dcp-1^Prev1 flies also display reduced autophagic flux.

Fed Dcp-1^Prev1 flies expressing Avic\GFP^{E.Scer\UAS.P\T.T:Hsap\Mito-COX8A} in the germline contain mitochondria with an altered morphology even in the absence of starvation. Approximately 54% of midstage egg chambers from Dcp-1^Prev1 flies contain mitochondria that are elongated and overly connected, whereas only 39% of midstage egg chambers contain mitochondria that are healthy.

ATP levels are significantly increased in ovaries from Dcp-1^Prev1 flies subjected to starvation conditions.

(DeVorkin et al., 2014)

As in wild type, no bursCCAP neuron somata are seen in the ventral nerve cord of Dcp-1^Prev1 mutant flies at 3-5 days post-eclosion. However the usual post-eclosion cell death is slightly delayed. Some neurites are still present at 3-5 days.

(Lee et al., 2013)

Dcp-1^Prev1 mutant flies exhibit slightly increased levels of spermatogonial cyst death compared to controls.

(Yacobi-Sharon et al., 2013)

Engulfment of nurse cells by follicle cells is largely inhibited in homozygous Dcp-1^Prev1 mutant starvation-induced degenerating egg chambers. Most follicle cells fail to enlarge and display thinning out of the membranes.

(Etchegaray et al., 2012)

Dcp-1^Prev1 mutants display a significant delay of ~1hr in the rate of cell death, reaching the wild-type plateau level 4hrs after irradiation.

Dcp-1^Prev1 mutants do not exhibit a difference in survival rate compared to wild-type controls.

(Florentin and Arama, 2012)

Homozygous Dcp-1^Prev1 mutants are viable and do not display any defects in NMJ integrity or growth.

(Keller et al., 2011)

Dcp-1^Prev1 mutants exhibit an average of 9 vCrz somata at 7 hours after puparium formation, with no vCrz somata at 16 hours after puparium formation. The general morphology of vCrz neurons at 7 hours after puparium formation was comparable to those of wild-type at 4-5 hours after puparium formation, indicating that programmed cell death has been slowed down in the absence of Dcp-1 function.

(Lee et al., 2011)

Dcp-1^Prev1 mutants exhibit a mild reduction in dendritic branch pruning at 18 hours after puparium formation.

(Schoenmann et al., 2010)

Nutrient-deprived Dcp-1^Prev1 mutant flies display reduced levels of autophagy (punctate Lysotracker staining) in region two of the germarium and in stage eight degenerating egg chambers compared to controls.

Fewer apoptotic (TUNEL positive) cells are seen in region two cysts in nutrient-deprived Dcp-1^Prev1 mutant flies than are seen in wild type.

(Hou et al., 2008)

Developmental apoptosis is significantly reduced in homozygous third instar eye discs.

γ-ray induced apoptosis is not suppressed in homozygous third instar wing discs.

(Kondo et al., 2006)

The arista of Dcp-1^Prev1 flies appears wild type.

Dcp-1^Prev1 pupal eyes appear wild type.

(Muro et al., 2006)

Dcp-1^Prev1 homozygotes are viable and fertile. The ovaries of these flies are largely normal, but have occasional egg chambers lacking follicle cells. This phenotype is exacerbated by nutrient deprivation to a much greater degree than in wild-type. Degeneration of egg chambers correlates with ectopic expression of cell-death markers.

(Laundrie et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Dcp-1^Prev1 has abnormal cell death phenotype, enhanceable by Dronc^I29

(Lee et al., 2011)

NOT suppressed by

Statement

Reference

Dcp-1^Prev1 has decreased cell death phenotype, non-suppressible by Drice^Δ1

(Florentin and Arama, 2012)

Enhancer of

Statement

Reference

Dcp-1^Prev1 is an enhancer of abnormal cell death phenotype of Dronc^I29

(Lee et al., 2011)

Dcp-1[+]/Dcp-1^Prev1 is an enhancer of lethal | pupal stage phenotype of Drice^Δ1

(Muro et al., 2006)

Dcp-1^Prev1 is an enhancer of abnormal developmental rate | pupal stage phenotype of Drice^Δ1

(Muro et al., 2006)

Dcp-1^Prev1 is an enhancer of decreased cell death | embryonic stage phenotype of Drice¹⁷

(Xu et al., 2006)

Suppressor of

Statement

Reference

Dcp-1^Prev1/Dcp-1^Prev1 is a suppressor of increased cell death | oogenesis phenotype of Dyro^Δ6

(Shima et al., 2025)

Drice^Δ1, Dcp-1[+], Dcp-1^Prev1 is a suppressor of increased cell death phenotype of Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Dcp-1^Prev1 is a suppressor of abnormal neuroanatomy phenotype of Ank2^f02001

(Keller et al., 2011)

Dcp-1[+]/Dcp-1^Prev1 is a suppressor | partially of abnormal neuroanatomy phenotype of Ank2^f02001

(Keller et al., 2011)

NOT Suppressor of

Statement

Reference

Dcp-1^Prev1 is a non-suppressor of decreased cell death phenotype of Drice^Δ1

(Florentin and Arama, 2012)

Dcp-1^Prev1 is a non-suppressor of partially lethal - majority die | larval stage phenotype of Drice^Δ1

(Florentin and Arama, 2012)

Dcp-1^Prev1/Dcp-1^Prev1 is a non-suppressor of visible phenotype of hid^GMR.PG

(Kondo et al., 2006)

Other

Statement

Reference

Dcp-1^Prev1, Drice^Δ1 has increased cell death | recessive | P-stage phenotype

(Akagawa et al., 2015)

Dcp-1^Prev1, Drice¹⁷ has abnormal cell death | P-stage phenotype

(Akagawa et al., 2015)

Dcp-1^Prev1, Drice^Δ1 has lethal | pharate adult stage phenotype

(Lee et al., 2011)

Dcp-1^Prev1, Drice^Δ1 has abnormal developmental rate | pupal stage phenotype

(Lee et al., 2011)

Dcp-1^Prev1, Drice¹⁷ has abnormal cell death | germline clone phenotype

(Baum et al., 2007)

Phenotype Manifest In

Enhanced by

Statement

Reference

Dcp-1^Prev1 has neuron phenotype, enhanceable by Dronc^I29

(Lee et al., 2011)

Suppressed by

Statement

Reference

Dcp-1^Prev1 has egg chamber | nutrition conditional phenotype, suppressible by sesB^org

(DeVorkin et al., 2014)

Enhancer of

Statement

Reference

Dcp-1^Prev1 is an enhancer of neuron phenotype of Dronc^I29

(Lee et al., 2011)

Dcp-1[+]/Dcp-1^Prev1 is an enhancer of arista phenotype of Drice^Δ1

(Muro et al., 2006)

Dcp-1[+]/Dcp-1^Prev1 is an enhancer of male genitalia phenotype of Drice^Δ1

(Muro et al., 2006)

Suppressor of

Statement

Reference

Dcp-1^Prev1/Dcp-1^Prev1 is a suppressor | partially of ovary phenotype of Dyro^Δ6

(Shima et al., 2025)

Dcp-1^Prev1/Dcp-1^Prev1 is a suppressor | partially of egg chamber | absent phenotype of Dyro^Δ6

(Shima et al., 2025)

Drice^Δ1, Dcp-1[+], Dcp-1^Prev1 is a suppressor of eye phenotype of Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Dcp-1[+]/Dcp-1^Prev1 is a suppressor | partially of embryonic/larval neuromuscular junction phenotype of Ank2^f02001

(Keller et al., 2011)

Dcp-1^Prev1 is a suppressor of embryonic/larval neuromuscular junction phenotype of Ank2^f02001

(Keller et al., 2011)

NOT Suppressor of

Statement

Reference

Dcp-1^Prev1/Dcp-1^Prev1 is a non-suppressor of egg | absent phenotype of Dyro^Δ6

(Shima et al., 2025)

Dcp-1^Prev1 is a non-suppressor of wing disc phenotype of Drice^Δ1

(Florentin and Arama, 2012)

Dcp-1^Prev1/Dcp-1^Prev1 is a non-suppressor of eye phenotype of hid^GMR.PG

(Kondo et al., 2006)

Other

Statement

Reference

Dcp-1^Prev1, Drice^Δ1 has adult optic lobe | P-stage phenotype

(Akagawa et al., 2015)

Dcp-1^Prev1, Drice¹⁷ has adult optic lobe | P-stage phenotype

(Akagawa et al., 2015)

Dcp-1^Prev1, sesB^org has nurse cell phenotype

(DeVorkin et al., 2014)

Dcp-1^Prev1, Drice^Δ1 has neuron phenotype

(Lee et al., 2011)

Dcp-1^Prev1, Drice¹⁷ has egg chamber | germline clone phenotype

(Baum et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

In Drice^Δ1 and Dcp-1^Prev1 double mutants, the number of apoptotic cells throughout the optic lobe is greatly reduced, though a few apoptotic cells are detectable in the some regions at 48h, when in wild type there are no apoptotic cells in these regions.

In Drice¹⁷ and Dcp-1^Prev1 double mutants, the number of apoptotic cells is reduced compared to wild type between 0-24h APF, and is slightly increased between 48-72h APF.

(Akagawa et al., 2015)

Degenerating midstage egg chambers from nutrient-deprived sesB^org/+; Dcp-1^Prev1/Dcp-1^Prev1 flies contain persisting nurse cell nuclei and an accumulation of ref(2)P protein.

Ovarioles from fed sesB^org/sesB^org; Dcp-1^Prev1/Dcp-1^Prev1 flies arrested during mid-oogenesis, and these midstage egg chambers contain condensed and fragmented nurse cell nuclei and reduced ref(2)P levels.

(DeVorkin et al., 2014)

Dcp-1^Prev1; Ice^Δ1 double mutants exhibit a block on cell death after irradiation.

A Dcp-1^Prev1; Ice^Δ1 double mutant background fails to abolish the ability of Ice^fl.5'3'UTR mutants to induce cell death, although induction is at a reduced rate compared to in a Ice^Δ1 single mutant background.

(Florentin and Arama, 2012)

Homozygous Dcp-1^Prev1 suppresses the NMJ degeneration seen in Ank2^f02001 mutants. One copy of Dcp-1^Prev1 is also able to partially suppress the phenotype.

(Keller et al., 2011)

Dcp-1^Prev1; Nc^I29 double mutants exhibit an arrest of vCrz programmed cell death with all 16 vCrz neurons retained at 7 and 16 hours after puparium formation, compared to apoptosis of these neurons in wild-type controls.

(Lee et al., 2011)

Dcp-1^Prev1 ; Nc^I24/Nc^I29 Ice^Δ1 triple mutant larvae undergo cell death with morphology similar to the midgut of wild-type animals when analysed from -4 to -1 hours relative to puparium formation.

(Denton et al., 2009)

Females containing Dcp-1^Prev1 Ice¹⁷ double mutant germline clones have persisting nurse cell nuclei in 21% of stage 14 egg chambers.

(Baum et al., 2007)

Developmental apoptosis in the eye disc is completely absent in Dcp-1^Prev1 ; Ice^Δ2C8 double homozygous third instar larvae.

The reduction in adult eye size caused by expression of W^GMR.PG is not suppressed if the eye is made homozygous for Dcp-1^Prev1 (using the eyFLP method).

(Kondo et al., 2006)

The lethality of Ice^Δ1 is enhanced by Dcp-1^Prev1 : less than 1% of Dcp-1^Prev1/+, Ice^Δ1/Ice^Δ1 animals eclose and Dcp-1^Prev1/Dcp-1^Prev1; Ice^Δ1/Ice^Δ1 animals die prior to, or during, early pupal stages. Almost all Dcp-1^Prev1/Dcp-1^Prev1; Ice^Δ1/Ice^Δ1 pupae arrest development prior to head inversion.

Dcp-1^Prev1/+, Ice^Δ1 flies show an increased number of lateral branches on the arista compared to Ice^Δ1 single mutant flies. Additionally, the genitalia misrotation phenotype of Ice^Δ1 flies is increased to full penetrance in Dcp-1^Prev1/+, Ice^Δ1 flies.

(Muro et al., 2006)

Ice¹⁷ Dcp-1^Prev1 double mutant embryos derived from mutant female germline clones (so lacking maternal and zygotic function of Ice and Dcp-1 show significantly reduced levels of apoptosis compared to Ice¹⁷ single maternal and zygotic mutant embryos, containing only a few dying cells.

(Xu et al., 2006)

Xenogenetic Interactions

Statement

Reference

A Dcp-1^Prev1/+; Ice^Δ1/Ice^Δ1 background strongly suppresses the adult eye size defect found upon expression of Mmus\Gria1^Lc.Scer\UAS under the control of Scer\GAL4^hs.2sev.

(Yang et al., 2013)

Complementation and Rescue Data

Rescued by

Dcp-1^Prev1 is rescued by Scer\GAL4^{VP16.nanos.UTR}/Dcp-1^ΔN.UASp

(DeVorkin et al., 2014)

Dcp-1^Prev1 is rescued by Dcp-1^t4.4

(Laundrie et al., 2003)

Rescues

Dcp-1^Prev1 rescues Dcp-1^{Drice.5'3'UTR}

(Florentin and Arama, 2012)

Comments

A Dcp-1^Prev1 heterozygous or homozygous background abolishes the ability of Dcp-1^Ice.5'3'UTR mutants to induce cell death.

(Florentin and Arama, 2012)

The presence of egg chambers lacking follicle cells in nutrient deprived Dcp-1^Prev1 homozygotes is prevented by Dcp-1^t4.4.

(Laundrie et al., 2003)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

63814

y¹ w^*; Dcp-1^Prev1

Notes on Origin

Discoverer

raw^dcp-1 has been identified as a second-site mutation on the Dcp-1^Prev1 chromosome.

(Hao et al., 2019)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

Dcp-1^Prev1

(Tavignot et al., 2017, DeVorkin et al., 2014, Lee et al., 2011)

Dcp-1^Prev

(Yang et al., 2013, Schoenmann et al., 2010, Hou et al., 2008)

Dcp-1^prev

(Florentin and Arama, 2012)

dcp-1^Prev1

(Orr et al., 2020, Lee et al., 2013, Lee et al., 2013, Keller et al., 2011, Denton et al., 2009, Baum et al., 2007, Muro et al., 2006, Xu et al., 2006)

dcp-1^Prev

(Yacobi-Sharon et al., 2013)

dcp-1^prev1

(Sun et al., 2020, Hao et al., 2019, Akagawa et al., 2015, Etchegaray et al., 2012, Kondo et al., 2006, Mendes et al., 2006)

dcp-1^prev

(Tarayrah-Ibraheim et al., 2021, Napoletano et al., 2017)

dcp1^Prev1

(Lee et al., 2013, Amarneh et al., 2009)

dcp1^Prev

(Amcheslavsky et al., 2018)

dcp1^prev

(Shima et al., 2025)

ΔDcp-1

(Muro et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (28)

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