FlyBase Allele Report: Dmel\Strica[4]

General Information

Symbol

Dmel\Strica⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0244459

Feature type

allele

Associated gene

Dmel\Strica

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Baum et al., 2007)

Mutagen

Delta2-3 transposase

(Baum et al., 2007)

Progenitor genotype

P{XP}Strica^d06491

(Baum et al., 2007)

Cytology

Description

Imprecise excision of the progenitor insertion, resulting in a 2.63kb deletion which removes genomic sequence from 355bp upstream of the original insertion site, the entire 527 amino acid dream coding region and all of the transcribed region of dream except the final 70bp.

(Baum et al., 2007)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2R:6,020,938..6,023,580 [-]

Comment:

Estimated boundaries of a 2.63 kb deletion resulting from the imprecise excision of P{XP}Strica^d06491 that removes sequences from 355 bases upstream of the insertion to 70 bases from the end of Strica-RA.

(Baum et al., 2007)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage

(Lee et al., 2013)

decreased cell death | adult stage

(Lee et al., 2013)

fertile

(Baum et al., 2007)

viable

(Baum et al., 2007)

Phenotype Manifest In

peptidergic neuron | adult stage | ectopic

(Lee et al., 2013)

Detailed Description

Statement

Reference

Strica⁴ homozygotes do not exhibit a significant proportion of hyperplastic testes, as compared to controls.

(Napoletano et al., 2017)

The programmed cell death of bursCCAP neurons seen in the adult ventral nerve cord of wild type flies after eclosion is strongly suppressed in dream⁴ mutant homozygotes.

(Lee et al., 2013)

dream⁴ mutant males exhibit a similar amount of spermatogonial cyst death to wild type controls.

(Yacobi-Sharon et al., 2013)

dream⁴ homozygotes exhibit wild-type apoptosis of vCrz neurons, with no viable vCrz neurons detected at 7 hours after puparium formation.

(Lee et al., 2011)

No abnormal mid-stage egg chambers are seen in the ovaries of homozygous or dream⁴/Df(2R)nap9 females.

(Baum et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Strica⁴ has abnormal cell death phenotype, enhanceable by Dronc^I24

(Lee et al., 2011)

NOT Enhanced by

Statement

Reference

Dronc^I24, Strica⁴ has abnormal cell death phenotype, non-enhanceable by Dredd^B118

(Lee et al., 2011)

NOT suppressed by

Statement

Reference

Dronc^I24, Strica⁴ has abnormal cell death phenotype, non-suppressible by Dredd^B118

(Lee et al., 2011)

Enhancer of

Statement

Reference

Strica⁴ is an enhancer of abnormal cell death phenotype of Dronc^I24

(Lee et al., 2011)

Strica⁴ is an enhancer of abnormal cell death phenotype of Dronc^I24/Dronc⁵¹

(Lee et al., 2011)

NOT Suppressor of

Statement

Reference

Strica⁴ is a non-suppressor of cell lethal | somatic clone phenotype of RpS3^Plac92

(Kale et al., 2015)

Strica⁴ is a non-suppressor of increased cell death | somatic clone phenotype of RpS3^Plac92

(Kale et al., 2015)

Other

Statement

Reference

Dredd^B118/Dredd[+], Strica⁴ has abnormal neuroanatomy | adult stage phenotype

(Lee et al., 2013)

Dredd^B118/Dredd[+], Strica⁴ has decreased cell death | adult stage phenotype

(Lee et al., 2013)

Dronc^I24, Strica⁴ has female fertile | germline clone phenotype

(Baum et al., 2007)

Dronc^I29, Strica⁴ has female fertile | germline clone phenotype

(Baum et al., 2007)

Phenotype Manifest In

Enhanced by

Statement

Reference

Strica⁴ has neuron phenotype, enhanceable by Dronc^I24

(Lee et al., 2011)

NOT Enhanced by

Statement

Reference

Dronc^I24, Strica⁴ has neuron phenotype, non-enhanceable by Dredd^B118

(Lee et al., 2011)

NOT suppressed by

Statement

Reference

Dronc^I24, Strica⁴ has neuron phenotype, non-suppressible by Dredd^B118

(Lee et al., 2011)

Enhancer of

Statement

Reference

Strica⁴ is an enhancer of neuron phenotype of Dronc^I24

(Lee et al., 2011)

Other

Statement

Reference

Dredd^B118/Dredd[+], Strica⁴ has peptidergic neuron | ectopic | adult stage phenotype

(Lee et al., 2013)

Dronc^I24, Strica⁴ has egg chamber | germline clone phenotype

(Baum et al., 2007)

Dronc^I29, Strica⁴ has egg chamber | germline clone phenotype

(Baum et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

The programmed cell death of bursCCAP neurons seen in the adult ventral nerve cord of wild type flies after eclosion is strongly suppressed in dream⁴/Dredd^B118 mutants.

(Lee et al., 2013)

Nearly all vCrz neurons are present at 7 hours after puparium formation in dream⁴; Nc^I24 double mutants. Such an abnormal programmed cell death phenotype is significantly more severe than in either single mutant. No surviving vCrz neurons are found at 7 hours after puparium formation in dream⁴; Nc^I24/+ mutants, suggesting that heterozygosity of Nc is sufficient to compensate for the lack of dream function.

Triple mutants of Dredd^B118; dream⁴; Nc^I24 display results comparable to dream⁴; Nc^I24 double mutants, i.e. all vCrz neurons are still present having not undergone apoptosis by 7 hours after puparium formation.

(Lee et al., 2011)

dream⁴ ; Nc^I24/Nc^I29 Ice^Δ1 triple mutant larvae show high levels of TUNEL staining at -4 to -1 hours relative to puparium formation, suggesting that they are undergoing cell death.

(Denton et al., 2009)

Females containing dream⁴ ; Nc^I24 double homozygous germline clones are fertile, but their ovaries contain 31% of mid-stage egg chambers with missing follicle cells and large surviving nurse cells. There is also an increase in mid-stage egg chambers containing condensed nurse cell nuclei but lacking follicle cells. 16% of stage 14 egg chambers contain persisting nurse cell nuclei.

Females containing dream⁴ ; Nc^I29 double homozygous germline clones are fertile, but their ovaries contain 46% of mid-stage egg chambers with missing follicle cells and large surviving nurse cells. Many of these egg chambers contain excessive numbers of nurse cells. There is also an increase in mid-stage egg chambers containing condensed nurse cell nuclei but lacking follicle cells. 21% of stage 14 egg chambers contain persisting nurse cell nuclei.

No significant defects is seen in the egg chambers of females containing dream²/dream⁴ ; Nc^I29 double homozygous germline clones.

Dredd^B118 dream⁴ double mutant females do not show any defects during oogenesis.

(Baum et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

63817

y¹ w^*; Strica⁴/CyO, y⁺

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Strica⁴

dream⁴

(Kale et al., 2015)

strica⁴

(Tarayrah-Ibraheim et al., 2021, Napoletano et al., 2017, Lee et al., 2013, Lee et al., 2013, Yacobi-Sharon et al., 2013, Florentin and Arama, 2012, Lee et al., 2011, Denton et al., 2009, Baum et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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