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General Information
Symbol
Dmel\DarkCD8
Species
D. melanogaster
Name
FlyBase ID
FBal0101816
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference

Insertion of a P{lacW} element in the first intron (the P{lacW}Arkk11502 insertion upstream of the Ark promoter is retained).

Insertion components
P{lacW}DarkCD8
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Most homozygotes survive to adulthood, although at a lower frequency than heterozygous siblings. Many homozygotes derived from heterozygous parents have melanotic tumours and abnormalities affecting the wings and/or bristles. Most affected flies have severe wing defects similar to a 'gnarled' or 'wrinkled' phenotype, while others have wing blisters or burnt 'notched' wings. 8% of flies have melanotic tumours inside the body. Among flies with extra bristles, most have one extra anterior scutellar bristle, while a few have two extra anterior scutellar bristles and/or an extra posterior scutellar bristle. Homozygotes derived from homozygous parents have impaired viability and fecundity and have an increased penetrance and expression of similar defects to those seen in homozygotes derived from heterozygous parents.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The border follicle cell migration defect seen in egg chambers expressing Rac1N17.Scer\UAS under the control of Scer\GAL4slbo.2.6 is partially suppressed by ArkCD8/+, ArkCD8/ArkCD8 or ArkCD4/ArkCD8.

Suppresses the eye phenotype of flies expressing debclScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PF.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (6)