FlyBase Allele Report: Dmel\Diap1[21-2s]

General Information

Symbol

Dmel\Diap1^21-2s

Species

D. melanogaster

Name

FlyBase ID

FBal0103516

Feature type

allele

Associated gene

Dmel\Diap1

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: P105S. This mutation is in the C terminal end the first BIR domain.

(Goyal et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:16,039,676..16,039,676 [-]

Nucleotide change:

C16039676T

Amino acid change:

Reported amino acid change:

P105S

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Goyal et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

partially lethal - majority die | recessive

(Goyal et al., 2000)

viable (with Diap1⁴)

(Geisbrecht and Montell, 2004)

viable (with Diap1⁵)

(Geisbrecht and Montell, 2004)

viable (with Diap1^6B)

(Geisbrecht and Montell, 2004)

viable (with Diap1⁷)

(Geisbrecht and Montell, 2004)

Phenotype Manifest In

border follicle cell (with Diap1⁴)

(Geisbrecht and Montell, 2004)

border follicle cell (with Diap1⁵)

(Geisbrecht and Montell, 2004)

border follicle cell (with Diap1⁷)

(Geisbrecht and Montell, 2004)

border follicle cell | somatic clone

(Geisbrecht and Montell, 2004)

egg chamber (with Diap1⁵)

(Geisbrecht and Montell, 2004)

egg chamber (with Diap1^6B)

(Geisbrecht and Montell, 2004)

follicle cell | increased number (with Diap1⁵)

(Geisbrecht and Montell, 2004)

nurse cell | increased number (with Diap1⁵)

(Geisbrecht and Montell, 2004)

nurse cell | increased number (with Diap1^6B)

(Geisbrecht and Montell, 2004)

Detailed Description

Statement

Reference

13% of th⁴/th^21-2s egg chambers have border follicle cell migration defects. 11% of th⁷/th^21-2s egg chambers have border follicle cell migration defects. 14% of th⁵/th^21-2s egg chambers have border follicle cell migration defects, 25% have extra follicle cells and 3% have more than 15 nurse cells. 3% of th⁵/th^21-2s egg chambers show polarity defects. Less than 1% of th^6B/th^21-2s egg chambers have border follicle cell migration defects, while 10% have more than 15 nurse cells. 10% of th^6B/th^21-2s egg chambers show polarity defects. Homozygous follicle cells clones result in border follicle cell migration defects.

(Geisbrecht and Montell, 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

Diap1^21-2s/th[+] is an enhancer of border follicle cell phenotype of chic⁰¹³²⁰/chic^k13321

(Geisbrecht and Montell, 2004)

Diap1^21-2s/th[+] is an enhancer of border follicle cell phenotype of chic⁰¹³²⁰/chic²²¹

(Geisbrecht and Montell, 2004)

Suppressor of

Statement

Reference

Diap1^21-2s is a suppressor of phenotype of hid^GMR.PG

(Goyal et al., 2000)

Diap1^21-2s is a suppressor of phenotype of rpr^GMR.PW

(Goyal et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

51% of chic⁰¹³²⁰/chic^k13321 ; th^21-2s/+ egg chambers have border follicle cell migration defects. In some egg chambers, the border follicle cells migrate to the side of the egg chamber instead of through the middle of the nurse cells, a phenotype that is never seen in wild-type egg chambers. 48% of chic⁰¹³²⁰/chic²²¹ ; th^21-2s/+ egg chambers have border follicle cell migration defects.

(Geisbrecht and Montell, 2004)

Addition of th^21-2s weakly suppresses the phenotype seen in rpr^GMR.PW and W^GMR.PG flies.

(Goyal et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Diap1^21-2s

th^21-2s

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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