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General Information
Symbol
Dmel\Diap121-2s
Species
D. melanogaster
Name
FlyBase ID
FBal0103516
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Nucleotide change:

    C16039676T

    Amino acid change:

    P105S | Diap1-PA; P105S | Diap1-PB; P105S | Diap1-PC; P105S | Diap1-PD; P105S | Diap1-PE; P105S | Diap1-PF

    Reported amino acid change:

    P105S

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Amino acid replacement: P105S. This mutation is in the C terminal end the first BIR domain.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    13% of th4/th21-2s egg chambers have border follicle cell migration defects. 11% of th7/th21-2s egg chambers have border follicle cell migration defects. 14% of th5/th21-2s egg chambers have border follicle cell migration defects, 25% have extra follicle cells and 3% have more than 15 nurse cells. 3% of th5/th21-2s egg chambers show polarity defects. Less than 1% of th6B/th21-2s egg chambers have border follicle cell migration defects, while 10% have more than 15 nurse cells. 10% of th6B/th21-2s egg chambers show polarity defects. Homozygous follicle cells clones result in border follicle cell migration defects.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Enhancer of
    Statement
    Reference
    Suppressor of
    Statement
    Reference

    Diap121-2s is a suppressor of phenotype of hidGMR.PG/WGMR.PG

    Diap121-2s is a suppressor of phenotype of rprGMR.PW

    Additional Comments
    Genetic Interactions
    Statement
    Reference

    51% of chic01320/chick13321 ; th21-2s/+ egg chambers have border follicle cell migration defects. In some egg chambers, the border follicle cells migrate to the side of the egg chamber instead of through the middle of the nurse cells, a phenotype that is never seen in wild-type egg chambers. 48% of chic01320/chic221 ; th21-2s/+ egg chambers have border follicle cell migration defects.

    Addition of th21-2s weakly suppresses the phenotype seen in rprGMR.PW and WGMR.PG flies.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    Reported As
    Symbol Synonym
    Diap121-2s
    th21-2s
    Name Synonyms
    Secondary FlyBase IDs
      References (2)