Gene Group: GERMINAL CENTER KINASES

General Information

Name

GERMINAL CENTER KINASES

Species

D. melanogaster

Symbol

GCK

FlyBase ID

FBgg0000236

Date last reviewed

2022-11-01

Number of members

Description

Germinal center kinases (GCKs) are serine/threonine kinases characterised by an N-terminal STE20 kinase domain. They have diverse roles in signaling pathways; some are MAPK kinase kinase kinases, activating MAPK kinase kinases. (Adapted from FBrf0225276 and FBrf0228279).

Notes on Group

Stlk is predicted to be a pseudokinase based on sequence analysis (FBrf0209106) and is therefore omitted from this group.

Source Material

The GERMINAL CENTER KINASES Gene Group has been compiled using the following publication(s): Sopko et al., 2014, Manning et al., 2002, Dan et al., 2001, and Morrison et al., 2000 .

Key Gene Ontology (GO) terms

Molecular Function

protein serine/threonine kinase activity

Biological Process

protein phosphorylation

Cellular Component

Enzymatic activity

Enzyme name (EC)

2.7.11.-

Related Gene Groups

Parent group(s)

STE20 KINASES