FB2026_02 , released June 18, 2026
Allele: Dmel\ninaCΔ132
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General Information
Symbol
Dmel\ninaCΔ132
Species
D. melanogaster
Name
FlyBase ID
FBal0032276
Feature type
allele
Associated gene
Dmel\ninaC
Associated Insertion(s)
Carried in Construct
P{ninaCΔ132}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Porter et al., 1992)
Progenitor genotype
Carried in construct
P{ninaCΔ132}
Cytology
Description

Construct: The last 20bp of the tenth exon and the first 11bp of the 11th exon of the 4.8kb ninaC mRNA are fused together, deleting a 582bp intron and a 3' end processing signal. This specifically eliminates expression of the p132 ninaC protein.

(Porter et al., 1992)
Allele components
Component
Use(s)
Encoded product / tool
ninaC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing ninaCΔ132 in a ninaC5 background have a slower rate of termination of the photoresponse (measured using an electroretinogram recording) than wild-type flies after pre-exposure to light for 10 minutes.

      (Lee and Montell, 2004)

      Photoreceptors treated with 8-Br-cAMP or IBMX show slowing of macroscopic light response, as do wild type, but unlike ninaC5 or ninaCΔ174.

      (Chyb et al., 1999)

      Plateau response to steady light or flashing light is normal. Pupillary pigment migration is smaller than that in wild type.

      (Hofstee et al., 1996)

      The electroretinogram of ninaC5 flies carrying ninaCΔ132 does not differ with age or with rearing on a light/dark cycle, and no significant reduction in rhabdomeral diameter is seen after 21 days in a light/dark cycle.

      (Porter et al., 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Specifically eliminates expression of the P132 photoreceptor cell specific ninaC protein.

      (Porter et al., 1991)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ninaCΔ132
      (Mecklenburg et al., 2010, Venkatachalam et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)