FB2026_02 , released June 18, 2026
Allele: Dmel\ninaCΔB
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General Information
Symbol
Dmel\ninaCΔB
Species
D. melanogaster
Name
FlyBase ID
FBal0032278
Feature type
allele
Associated gene
Dmel\ninaC
Associated Insertion(s)
Carried in Construct
P{ninaCΔB}
Key Links
Transgenic product class
inframe_deletion
(Porter et al., 1993)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Porter et al., 1993)
Mutagen
in vitro construct
(Arnon et al., 1997, Porter et al., 1995, Porter et al., 1993)
Progenitor genotype
Carried in construct
P{ninaCΔB}
Cytology
Description

Deletion of residues 1037-1253.

(Porter et al., 1995)

Construct: Deletion of the Cam binding domain, the domain begins at the end of the myosin head region in the p174 isoform of ninaC.

(Porter et al., 1993)
Allele components
Component
Use(s)
Encoded product / tool
ninaC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The electroretinogram response of flies carrying ninaCΔB in a ninaC5 background is abnormal.

      (Wes et al., 1999)

      Photoreceptors are Cam deficient.

      (Arnon et al., 1997)

      The light-induced current of isolated ommatidia is disrupted by a specific inhibitor of calcium-calmodulin.

      (Arnon et al., 1997)

      ERG recording of the summed response of all retinal cells to light is indistinguishable from ninaC5 (a large corneal negative response after a 90 second dark adaption, followed by a slow return to baseline and a small or absent off-transient upon cessation of the initial light stimulus). Flies show a prolonged depolarization afterpotential (PDA) under reduced blue light intensities that did not induce PDAs in wild type or in ninaC5.

      (Porter et al., 1995)

      Deletion of the Cam binding domain causes a defect in phototransduction, displayed by a defective ERG. Flies do not undergo the age- and light-dependent retinal degradation.

      (Porter et al., 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ninaCΔB
      Name Synonyms
      Secondary FlyBase IDs
        References (6)