FB2026_02 , released June 18, 2026
Allele: Dmel\CG109395a
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General Information
Symbol
Dmel\CG109395a
Species
D. melanogaster
Name
FlyBase ID
FBal0359013
Feature type
allele
Associated gene
Dmel\CG10939
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    amorphic allele - molecular evidence

    (Ghimire et al., 2019)
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 1 )
        Disease
        Evidence
        References
        model of  hypophosphatemic nephrolithiasis/osteoporosis 2
        CEC
        (Ghimire et al., 2019)
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
         

        FlyBase curator comment: "hypophosphatemic nephrolithiasis/osteoporosis 2" is associated with mutations in the CG10939 ortholog, human SLC9A3R1 (aka NHERF1).

        (Ghimire et al., 2019)
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        CG109395a homozygous adults present numerous birefringent stones in the Malpighian tubules's lumen; these stones start dissolving with pH > 6.7.

        (Ghimire et al., 2019)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        CG109395a
        Sip15a
        (Ghimire et al., 2019)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)