FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\X11LRNAi.UAS.cGa
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General Information
Symbol
Dmel\X11LRNAi.UAS.cGa
Species
D. melanogaster
Name
FlyBase ID
FBal0304607
Feature type
allele
Associated gene
Dmel\X11L
Associated Insertion(s)
Carried in Construct
P{UAS-X11L.RNAi.G}
Key Links
Transgenic product class
RNAi_reagent
(Gross et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Gross et al., 2013)
Mutagen
in vitro construct
(Gross et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-X11L.RNAi.G}
Cytology
Description

The X11L coding region is targeted with microRNA technology to silence X11Lβ. These miRNA are cloned downstream of UAS regulatory sequences.

(Gross et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
X11L
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of X11LdsRNA.Scer\UAS.cGa under the control of the mushroom body driver Scer\GAL4ey-OK107 does not cause structural phenotypes in the larval mushroom body. However, lobe defects are seen in the adult brain.

      (Gross et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Pan-neuronal silencing of X11LdsRNA.Scer\UAS.cGa and X11LβdsRNA.Scer\UAS, under the control of Scer\GAL4elav.PU results in early to mid-third instar larval lethality.

      Flies expressing X11LdsRNA.Scer\UAS.cGa and shiK44A.Scer\UAS in the mushroom body, under the control of Scer\GAL4ey-OK107, are embryonic lethal, indicating a robust genetic interaction between X11L and shi. Raising these flies at a lower temperature (so reducing expression of these transgenes) results in viable flies, displaying aberrant anatomical development of the medial and dorsal lobes.

      (Gross et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      X11LRNAi.UAS.cGa
      X11LdsRNA.Scer\UAS.cGa
      X11LdsRNA.UAS.cGa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)