FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\numb4
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General Information
Symbol
Dmel\numb4
Species
D. melanogaster
Name
FlyBase ID
FBal0090215
Feature type
allele
Associated gene
Dmel\numb
Associated Insertion(s)
Carried in Construct
Also Known As
nb4
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
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    Associated Sequence Data
    DDBJ / EMBL / GenBank
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    UniProtKB/Swiss-Prot
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        Expression Data
        Reporter Expression
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        Marker for
        Reflects expression of
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        Human Disease Associations
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        Models Based on Experimental Evidence ( 0 )
        Disease
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        Modifiers Based on Experimental Evidence ( 0 )
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        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        numb4 clones generated in the larval eye disc lead to rare ommatidial rotation phenotypes - i.e. planar cell polarity defects.

        (Domingos et al., 2019)

        Embryos lacking both maternal and zygotic numb, produced by making numb4 germline clones, display near-complete expressivity of numb phenotypes. Both progeny from the GMC4-2a ganglion mother cell appear to adopt the RP2sib neuronal fate. Both progeny from the GMC1-1a ganglion mother cell appear to adopt the pCC neuronal fate. Both progeny from the ganglion mother cell that normally mothers the U/CQ and U/CQ sibling neurons appear to adopt the U/CQ neuron fate. EL neurons almost completely fail to appear. Maternal loss alone has almost no effect on RP2/RP2sib, U/Usib, EL, and pCC/aCC lineages. Zygotic loss of numb4 allows about 2/3 the wild-type number of RP2 neurons, about 1.5 times the wild-type number of U/CQ neurons, and about 1/10 of the normal number of EL neurons to develop. the pCC/aCC lineage appears to be unaffected.

        (Lear et al., 1999)

        The RP2sib neuron, vMP2 neuron and U neuron are all duplicated at the expense of their siblings. The number of EL neurons is strongly reduced. pCC/aCC are unaffected. This phenotype is the reciprocal of that shown for spdo, Dl, N and mam embryos.

        (Skeath and Doe, 1998)
        External Data
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        Mutant
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        Notes on Origin
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        Comments
        Comments

        On the basis of CNS phenotype numb alleles form a series: numb2 > numb4 > numb1/numb3.

        (Skeath and Doe, 1998)

        Complements: spen03350. Complements: kis07812. Complements: spenk07612. Complements: spenk07721. Complements: kisk08319. Complements: spenk10325.

        (BDGP Project Members, 1994-1999)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        l(2)06740
        (Skeath and Doe, 1998)
        nb4
        (Lear et al., 1999, Skeath and Doe, 1998)
        numb4
        (Domingos et al., 2019)
        Name Synonyms
        Secondary FlyBase IDs
          References (6)