FlyBase Allele Report: Dmel\numb[UAS.cOa]

General Information

Symbol

Dmel\numb^UAS.cOa

Species

D. melanogaster

Name

FlyBase ID

FBal0268711

Feature type

allele

Associated gene

Dmel\numb

Associated Insertion(s)

Carried in Construct

P{UAS-numb.O}

Also Known As

UAS-Numb

Key Links

Transgenic product class

wild_type

(Ouyang et al., 2011)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Ouyang et al., 2011)

Mutagen

in vitro construct

(Ouyang et al., 2011)

Progenitor genotype

Carried in construct

P{UAS-numb.O}

Cytology

Description

UAS regulatory sequences drive expression of wild-type numb coding sequences.

(Ouyang et al., 2011)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

numb

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage, with Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

decreased cell number | larval stage, with Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

Phenotype Manifest In

type II neuroblast | larval stage, with Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

Detailed Description

Statement

Reference

Larval brains expressing numb^Scer\UAS.cOa under the control of Scer\GAL4^insc-Mz1407 exhibit a complete loss of type II neuroblasts, as compared to controls.

(Wu et al., 2017)

Overexpression of numb^Scer\UAS.cOa in larval brain neuroblasts under the control of Scer\GAL4^insc-Mz1407 does not affect neuroblast number.

(Ouyang et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^insc-Mz1407, numb^UAS.cOa has decreased cell number | larval stage phenotype, suppressible | partially by HUWE1^HMS01605/Myc^UAS.cZa, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

Scer\GAL4^insc-Mz1407, numb^UAS.cOa has abnormal neuroanatomy | larval stage phenotype, suppressible | partially by HUWE1^HMS01605/Myc^UAS.cZa, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

NOT suppressed by

Statement

Reference

Scer\GAL4^insc-Mz1407, numb^UAS.cOa has decreased cell number | larval stage phenotype, non-suppressible by Myc^UAS.cZa, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

Scer\GAL4^insc-Mz1407, numb^UAS.cOa has abnormal neuroanatomy | larval stage phenotype, non-suppressible by Myc^UAS.cZa, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

NOT Suppressor of

Statement

Reference

numb^UAS.cOa, Scer\GAL4^Toll-6-D42 is a non-suppressor of short lived phenotype of Hsap\TARDBP^UAS.cHa, Scer\GAL4^Toll-6-D42

(Zhan et al., 2013)

Scer\GAL4^insc-Mz1407/numb^UAS.cOa is a non-suppressor of abnormal neuroanatomy | somatic clone phenotype of mts²⁹⁹

(Ouyang et al., 2011)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^insc-Mz1407, numb^UAS.cOa has type II neuroblast | larval stage phenotype, suppressible | partially by HUWE1^HMS01605/Myc^UAS.cZa, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

NOT suppressed by

Statement

Reference

Scer\GAL4^insc-Mz1407, numb^UAS.cOa has type II neuroblast | larval stage phenotype, non-suppressible by Myc^UAS.cZa, Scer\GAL4^insc-Mz1407

(Wu et al., 2017)

NOT Suppressor of

Statement

Reference

Scer\GAL4^insc-Mz1407/numb^UAS.cOa is a non-suppressor of type II neuroblast | increased number | somatic clone phenotype of mts²⁹⁹

(Ouyang et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of both Myc^Scer\UAS.cZa and CG8184^HMS01605 (but not Myc^Scer\UAS.cZa alone) partially rescues the type II neuroblast loss phenotype seen in larval brains expressing numb^Scer\UAS.cOa under the control of Scer\GAL4^insc-Mz1407.

(Wu et al., 2017)

Expression of numb^Scer\UAS.cOa does not suppress the ectopic type II neuroblasts found in mts²⁹⁹ type II neuroblast clones.

(Ouyang et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^insc-Mz1407/numb^UAS.cOa rescues numb¹⁵

(Ouyang et al., 2011)

Comments

Expression of numb^Scer\UAS.cOa suppresses the ectopic neuroblast formation seen in numb¹⁵ mutant clones

(Ouyang et al., 2011)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

numb^Scer\UAS.cOa

numb^UAS.cOa

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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