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General Information
Symbol
Dmel\numbUAS.cOa
Species
D. melanogaster
Name
FlyBase ID
FBal0268711
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Numb
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of wild-type numb coding sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Larval brains expressing numbScer\UAS.cOa under the control of Scer\GAL4insc-Mz1407 exhibit a complete loss of type II neuroblasts, as compared to controls.

Overexpression of numbScer\UAS.cOa in larval brain neuroblasts under the control of Scer\GAL4insc-Mz1407 does not affect neuroblast number.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
NOT suppressed by
NOT Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of both MycScer\UAS.cZa and CG8184HMS01605 (but not MycScer\UAS.cZa alone) partially rescues the type II neuroblast loss phenotype seen in larval brains expressing numbScer\UAS.cOa under the control of Scer\GAL4insc-Mz1407.

Expression of numbScer\UAS.cOa does not suppress the ectopic type II neuroblasts found in mts299 type II neuroblast clones.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of numbScer\UAS.cOa suppresses the ectopic neuroblast formation seen in numb15 mutant clones

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
numbScer\UAS.cOa
numbUAS.cOa
Name Synonyms
Secondary FlyBase IDs
    References (3)