numb15 clones generated in the larval eye disc do not result in ommatidial rotation phenotypes (planar cell polarity defects).
numb15/numbNP2301 transheterozygosity leads to supernumerary type II neuroblasts in the larval optic lobe.
Centrosome asymmetry during cytokinesis in mutant pI (sensory organ precursor) cells in the notum is strongly reduced compared to that seen in wild-type pI cells, as the posterior centrosome movement towards the cell apex is delayed in the mutant cells.
Homozygous clones in the sensory organs of the leg produce four socket cells. These sensory organs fail to induce bracts. The mutant sensory organ socket cells do not show the protrusions normally seen projecting from the basolateral surface of the proximal side of wild-type socket cells.
Ectopic neuroblast formation is seen in numb15 mutant clones.
Homozygous clones in the optic lobe, induced during the first or early-second instar maintain neuroepithelial cell identity until the late-third instar and the differentiation of neuroepithelial cells into medulla neuroblasts is inhibited.
Homozygous intestinal stem cell clones form large clones over time, as do wild-type controls.
Homozygous clones in the larval brain show strong overproliferation in the PAN neuroblast lineage and weaker overproliferation in the ase[+] neuroblast lineage. Homozygous clones in the ventral nerve cord show neuroblast overproliferation.
numb15/numb15 clones have neuronal differentiation defects in the outer optic anlage of third instar larvae.
Homozygous neuroblast clones in the larval brain contain a greater number of cells compared to wild-type clones.
In numb15 embryos, 54% of all hemisegments show a complete loss of sensory neurons. In numb15 embryos, the midline neuroblast MP2 divides to give two vMP2 cells, instead of a vMP2 and a dMP2 neuron. In numb15 embryos, the GMC4-2a divides to give two RP2sib cells, instead of one RP2 neuron and one RP2sib cell. In numb15 stage 14-15 embryos, the DA1 precursors and DO1 precursors are absent, as FDA1 and FDO1 are transformed into their sibling cells. In numb15 embryos, the P2 precursor divides symmetrically and generates four pericardial cells, instead of dividing asymmetrically and giving rise to a DO2 muscle founder and a sibling that divides into two pericardial cells.
In somatic clones of numb15 in the head, almost all bristles are transformed into four sockets.