Open Close
General Information
Symbol
Dmel\bratDG19310
Species
D. melanogaster
Name
FlyBase ID
FBal0215708
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Insertion components
P{wHy}bratDG19310
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

brat1/bratDG19310 transheterozygosity leads to supernumerary type II neuroblasts in the larval optic lobe.

bratDG19310/brat11 mutant clones originating from either a single ase+ immature intermediate neural progenitor (INP) or INP contain a similar number of neuroblasts (reverted clones) as controls.

brat11/bratDG19310 larval brains contain supernumerary type II neuroblasts.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

bratDG19310/brat11 has abnormal neuroanatomy phenotype, enhanceable by erm[+]/erm1

bratDG19310/brat11 has abnormal neuroanatomy phenotype, enhanceable by brm[+]/brm2

bratDG19310/brat11 has abnormal neuroanatomy phenotype, enhanceable by mor[+]/mor1

NOT Enhanced by
Suppressed by
Statement
Reference
NOT suppressed by
Enhancer of
Other
Phenotype Manifest In
Enhanced by
Statement
Reference
NOT Enhanced by
Suppressed by
Statement
Reference
NOT suppressed by
Enhancer of
Other
Additional Comments
Genetic Interactions
Statement
Reference

One copy of erm1 enhances the supernumerary type II neuroblast phenotype seen in bratDG19310/brat11 mutants.

In contrast to bratDG19310/brat11 clones alone, clones originating from either a single ase+ immature Intermediate Neural Progenitor (INP) or INP that are also heterozygous for erm1 contain an increased number of neuroblasts 'reverted clones'. This phenotype is reversed upon expression of ermScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR9D11. This rescue is seen using an insertion line of the driver that expressed in ase[-] INPs (P{GMR9D11-GAL4}2) and one that expresses in ase[+] INPs (P{GMR9D11-GAL4}attP2).

Expression of ermScer\UAS.T:Ivir\HA1 under the control of an insertion of Scer\GAL4GMR9D11 that expresses in ase[-] immature Intermediate Neural Progenitors (INPs) (P{GMR9D11-GAL4}2) suppresses the supernumerary neuroblast phenotype seen in bratDG19310/brat11 mutant larval brains. Expression of ermScer\UAS.T:Ivir\HA1 using a line that expresses in ase[+] INPs (P{GMR9D11-GAL4}attP2) does not suppress the phenotype.

Expression of kluScer\UAS.T:Ivir\HA1 under the control of an insertion of Scer\GAL4GMR9D11 that expresses in ase[-] immature Intermediate Neural Progenitors (INPs) (P{GMR9D11-GAL4}2) enhances the supernumerary neuroblast phenotype seen in bratDG19310/brat11 mutant larval brains. No enhancement is seen when kluScer\UAS.T:Ivir\HA1 is expressed using an insertion of Scer\GAL4GMR9D11 that expresses in ase[+] INPs (P{GMR9D11-GAL4}attP2).

Expression of dpnScer\UAS.cWa under the control of an insertion of Scer\GAL4GMR9D11 that expresses in ase[-] immature Intermediate Neural Progenitors (INPs) (P{GMR9D11-GAL4}2) enhances the supernumerary neuroblast phenotype seen in bratDG19310/brat11 mutant larval brains. A milder enhancement is seen when dpnScer\UAS.cWa is expressed using an insertion of Scer\GAL4GMR9D11 that expresses in ase[+] INPs (P{GMR9D11-GAL4}attP2).

Expression of E(spl)mγ-HLHScer\UAS.cLa under the control of an insertion of Scer\GAL4GMR9D11 that expresses in ase[-] immature Intermediate Neural Progenitors (INPs) (P{GMR9D11-GAL4}2) strongly enhances the supernumerary neuroblast phenotype seen in bratDG19310/brat11 mutant larval brains. A milder enhancement is seen when E(spl)mγ-HLHScer\UAS.cLa is expressed using an insertion of Scer\GAL4GMR9D11 that expresses in ase[+] INPs (P{GMR9D11-GAL4}attP2).

One copy of osa308 enhances the supernumerary neuroblast phenotype seen in bratDG19310/brat11 mutants.

One copy of brm2 enhances the supernumerary neuroblast phenotype seen in bratDG19310/brat11 mutants.

One copy of mor1 enhances the supernumerary neuroblast phenotype seen in bratDG19310/brat11 mutants.

Expression of brmK804R.Scer\UAS.T:Ivir\HA1 under the control of an insertion of Scer\GAL4GMR9D11 that expresses in ase[-] immature Intermediate Neural Progenitors (INPs) (P{GMR9D11-GAL4}2) enhances the supernumerary neuroblast phenotype seen in bratDG19310/brat11 mutant larval brains. Expression of brmK804R.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4wor.PA also enhances the phenotype. No enhancement is seen when brmK804R.Scer\UAS.T:Ivir\HA1 is expressed using an insertion of Scer\GAL4GMR9D11 that expresses in ase[+] INPs (P{GMR9D11-GAL4}attP2).

Expression of armS10.Scer\UAS.T:Hsap\MYC in type II neuroblasts or ase- immature intermediate neural progenitors (INPs) enhances the supernumerary neuroblast phenotype seen in bratDG19310/brat11 larval brains, whereas expression in ase+ immature INPs does not (different insertions of Scer\GAL4GMR9D11 are used to drive expression in each case).

Expression of panΔN.Scer\UAS in type II neuroblasts or ase- immature intermediate neural progenitors (INPs) suppresses the supernumerary neuroblast phenotype seen in bratDG19310/brat11 larval brains, whereas expression in ase+ immature INPs does not (different insertions of Scer\GAL4GMR9D11 are used to drive expression in each case).

kluunspecified/+ strongly suppresses the formation of supernumerary type II neuroblasts which is seen in brat11/bratDG19310 larval brains.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (6)