FlyBase Allele Report: Dmel\brat[DG19310]

General Information

Symbol

Dmel\brat^DG19310

Species

D. melanogaster

Name

FlyBase ID

FBal0215708

Feature type

allele

Associated gene

Dmel\brat

Associated Insertion(s)

P{wHy}brat^DG19310

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gelbart, 2008.3.31)

Progenitor genotype

Associated Insertion(s)

P{wHy}brat^DG19310

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:19,158,447..19,158,447 [-]

(Gelbart, 2008.3.31)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage

(Komori et al., 2014)

abnormal neuroanatomy | larval stage (with brat¹¹)

(Komori et al., 2014, Xiao et al., 2012)

increased cell number (with brat¹¹)

(Rajan et al., 2023)

increased cell number | larval stage (with brat¹¹)

(Komori et al., 2025, Komori et al., 2018)

Phenotype Manifest In

embryonic/larval optic lobe | larval stage (with brat¹¹)

(Komori et al., 2018)

neuroblast | increased number (with brat¹¹)

(Rajan et al., 2023)

type II neuroblast | increased number

(Komori et al., 2014)

type II neuroblast | increased number (with brat¹¹)

(Komori et al., 2025, Komori et al., 2014)

type II neuroblast | increased number | larval stage (with brat¹¹)

(Komori et al., 2018)

type II neuroblast | larval stage | increased number (with brat¹¹)

(Xiao et al., 2012)

Detailed Description

Statement

Reference

brat¹/brat^DG19310 transheterozygosity leads to supernumerary type II neuroblasts in the larval optic lobe.

(Komori et al., 2018)

brat^DG19310/brat¹¹ mutant clones originating from either a single ase+ immature intermediate neural progenitor (INP) or INP contain a similar number of neuroblasts (reverted clones) as controls.

(Janssens et al., 2014)

brat¹¹/brat^DG19310 larval brains contain supernumerary type II neuroblasts.

(Xiao et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Usp5^leon-2/Usp5^leon-1

(Komori et al., 2025)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Usp5^JF02163/Scer\GAL4^wor.PA

(Komori et al., 2025)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Usp5^leon-1/Usp5^leon-1

(Komori et al., 2025)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Scer\GAL4^wor.PA/Patr-1^HMS01144

(Komori et al., 2025)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by DCP2^HMS00115/Scer\GAL4^wor.PA

(Komori et al., 2025)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Scer\GAL4^wor.PA/tral^HM05028

(Komori et al., 2025)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Scer\GAL4^wor.PA/pcm^HMS01169

(Komori et al., 2025)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Scer\GAL4^wor.PA/Edc3^HMS00392

(Komori et al., 2025)

brat^DG19310/brat¹¹ has increased cell number phenotype, enhanceable by fru^AJ96u3

(Rajan et al., 2023)

brat^DG19310/brat¹¹ has increased cell number phenotype, enhanceable by fru^AJ96u3/fru^ΔC

(Rajan et al., 2023)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Df(3R)BSC56/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Tis11[+]/Tis11^IE35

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Df(1)BSC726/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Df(1)BSC623/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Not1^LL08100/Not1[+]

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Pop2^MB11505/Pop2[+]

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by PAN2^f00130/PAN2[+]

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by me31B^k06607/me31B[+]

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell growth rate | larval stage phenotype, enhanceable by Tis11^{H198Q.UAS.Tag:FLAG}/Tis11[+]/Scer\GAL4^wor.PA/Tis11^IE35/Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell growth rate | larval stage phenotype, enhanceable by Tis11[+]/Scer\GAL4^wor.PA/Tis11^{ΔNot1.UAS.Tag:FLAG}/Tis11^IE35/Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell growth rate | larval stage phenotype, enhanceable by Scer\GAL4^wor.PA/Cul1^HM05197/Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by numb^NP2301/numb¹⁵

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by insb^exA45

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Df(2L)ED94/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Df(2L)ED105/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Df(2L)BSC688/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Df(1)BSC625/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Df(2R)BSC355/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by +/Df(2L)BSC292

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by +/Df(3L)brm11

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Df(3L)BSC574/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by +/Df(3R)L127

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Df(3R)Exel7327/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by +/Df(2R)Exel7094

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by +/Df(2L)ED690

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by +/Df(2R)BSC161

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Df(2R)ED1791/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Df(2R)BSC408/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Df(3L)ED4288/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by +/Df(3R)Exel9012

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Df(3R)DG2/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, enhanceable by Df(3R)crb-F89-4/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has abnormal neuroanatomy phenotype, enhanceable by erm[+]/erm¹

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has abnormal neuroanatomy phenotype, enhanceable by osa[+]/osa³⁰⁸

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has abnormal neuroanatomy phenotype, enhanceable by brm[+]/brm²

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has abnormal neuroanatomy phenotype, enhanceable by mor[+]/mor¹

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has abnormal neuroanatomy phenotype, enhanceable by Scer\GAL4^GMR9D11/brm^{K804R.UAS.Tag:HA}

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has abnormal neuroanatomy phenotype, enhanceable by Scer\GAL4^wor.PA/brm^{K804R.UAS.Tag:HA}

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has abnormal neuroanatomy phenotype, enhanceable by klu^UAS.Tag:HA/Scer\GAL4^GMR9D11

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has abnormal neuroanatomy phenotype, enhanceable by dpn^UAS.cWa/Scer\GAL4^GMR9D11

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has abnormal neuroanatomy | larval stage phenotype, enhanceable by Apc2^g10/Apc2[+]

(Komori et al., 2014)

brat^DG19310/brat¹¹ has abnormal neuroanatomy | larval stage phenotype, enhanceable by CkIalpha[+]/CkIα^8B12

(Komori et al., 2014)

brat^DG19310/brat¹¹ has abnormal neuroanatomy | larval stage phenotype, enhanceable by sgg[+]/sgg^8E22

(Komori et al., 2014)

brat^DG19310/brat¹¹ has abnormal neuroanatomy | larval stage phenotype, enhanceable by Axn[+]/Axn^S044230

(Komori et al., 2014)

brat^DG19310/brat¹¹ has abnormal neuroanatomy | larval stage phenotype, enhanceable by Scer\GAL4^wor.PA/arm^{S10.UAS.Tag:MYC}

(Komori et al., 2014)

NOT Enhanced by

Statement

Reference

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, non-enhanceable by Uuuu\Ub^{AA.UAS.Tag:HA}/Scer\GAL4^wor.PA

(Komori et al., 2025)

brat^DG19310/brat¹¹ has increased cell growth rate | larval stage phenotype, non-enhanceable by Tis11[+]/Scer\GAL4^wor.PA/Tis11^{UAS.cKa.Tag:FLAG}/Tis11^IE35/Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹ has abnormal neuroanatomy phenotype, non-enhanceable by Scer\GAL4^GMR9D11/brm^{K804R.UAS.Tag:HA}

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has abnormal neuroanatomy phenotype, non-enhanceable by klu^UAS.Tag:HA/Scer\GAL4^GMR9D11

(Janssens et al., 2014)

Suppressed by

Statement

Reference

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, suppressible by dpn[+]/dpn¹

(Komori et al., 2025, Komori et al., 2018)

Usp5^leon-1, brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, suppressible by Scer\GAL4^GMR9D11/Usp5^UAS.Tag:FLAG

(Komori et al., 2025)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, suppressible by Df(1)ED6565/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, suppressible by Df(3R)3450/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, suppressible by +/Df(3L)BSC377

(Komori et al., 2018)

brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, suppressible by Df(3R)Tl-P/+

(Komori et al., 2018)

Df(2R)ED1791/+, brat^DG19310/brat¹¹ has increased cell growth rate | larval stage phenotype, suppressible | partially by Scer\GAL4^wor.PA/PAN2^UAS.Tag:V5/Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹, insb^exA45 has increased cell number | larval stage phenotype, suppressible by insb^cKa.GFP

(Komori et al., 2018)

Tis11^IE35, brat^DG19310/brat¹¹ has increased cell number | larval stage phenotype, suppressible by dpn[+]/dpn¹

(Komori et al., 2018)

brat^DG19310/brat¹¹, insb^exA45 has increased cell number | larval stage phenotype, suppressible by dpn[+]/dpn¹

(Komori et al., 2018)

brat^DG19310/brat¹¹ has abnormal neuroanatomy phenotype, suppressible by Scer\GAL4^GMR9D11/erm^UAS.Tag:HA

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has abnormal neuroanatomy phenotype, suppressible by E(spl)mγ-HLH^UAS.cLa/Scer\GAL4^GMR9D11

(Janssens et al., 2014)

brat^DG19310/brat¹¹, erm[+]/erm¹ has abnormal neuroanatomy | somatic clone phenotype, suppressible by Scer\GAL4^GMR9D11/erm^UAS.Tag:HA

(Janssens et al., 2014)

Apc2^g10/Apc2[+], brat^DG19310/brat¹¹ has abnormal neuroanatomy | larval stage phenotype, suppressible | partially by arm⁸/arm[+]

(Komori et al., 2014)

brat^DG19310/brat¹¹ has abnormal neuroanatomy | larval stage phenotype, suppressible by klu[+]/klu^unspecified

(Xiao et al., 2012)

NOT suppressed by

Statement

Reference

Df(2R)ED1791/+, brat^DG19310/brat¹¹ has increased cell growth rate | larval stage phenotype, non-suppressible by PAN2^{D1039N.E1041Q.UAS.Tag:V5}/Scer\GAL4^wor.PA/Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹ has abnormal neuroanatomy phenotype, non-suppressible by Scer\GAL4^GMR9D11/erm^UAS.Tag:HA

(Janssens et al., 2014)

Enhancer of

Statement

Reference

brat^DG19310/brat¹¹ is an enhancer of increased cell growth rate | larval stage phenotype of Cul1^HM05197, Scer\GAL4^wor.PA, Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹ is an enhancer of increased cell number | larval stage phenotype of numb^NP2301/numb¹⁵

(Komori et al., 2018)

Other

Statement

Reference

brat^DG19310/brat¹¹, erm[+]/erm¹ has abnormal neuroanatomy | somatic clone phenotype

(Janssens et al., 2014)

Phenotype Manifest In

Enhanced by

Statement

Reference

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by Usp5^leon-2/Usp5^leon-1

(Komori et al., 2025)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by Usp5^JF02163/Scer\GAL4^wor.PA

(Komori et al., 2025)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by Usp5^leon-1/Usp5^leon-1

(Komori et al., 2025)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by Scer\GAL4^wor.PA/Patr-1^HMS01144

(Komori et al., 2025)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by DCP2^HMS00115/Scer\GAL4^wor.PA

(Komori et al., 2025)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by Scer\GAL4^wor.PA/tral^HM05028

(Komori et al., 2025)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by Scer\GAL4^wor.PA/pcm^HMS01169

(Komori et al., 2025)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by Scer\GAL4^wor.PA/Edc3^HMS00392

(Komori et al., 2025)

brat^DG19310/brat¹¹ has neuroblast | increased number phenotype, enhanceable by fru^AJ96u3

(Rajan et al., 2023)

brat^DG19310/brat¹¹ has neuroblast | increased number phenotype, enhanceable by fru^AJ96u3/fru^ΔC

(Rajan et al., 2023)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Df(3R)BSC56/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Tis11[+]/Tis11^IE35

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Tis11[+]/Tis11^IE35

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Df(1)BSC726/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Df(1)BSC726/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Df(1)BSC623/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Df(1)BSC623/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Not1^LL08100/Not1[+]

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Not1^LL08100/Not1[+]

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Pop2^MB11505/Pop2[+]

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Pop2^MB11505/Pop2[+]

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by PAN2^f00130/PAN2[+]

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by PAN2^f00130/PAN2[+]

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by me31B^k06607/me31B[+]

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by me31B^k06607/me31B[+]

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Tis11^{H198Q.UAS.Tag:FLAG}/Tis11[+]/Scer\GAL4^wor.PA/Tis11^IE35/Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage phenotype, enhanceable by Tis11^{H198Q.UAS.Tag:FLAG}/Tis11[+]/Scer\GAL4^wor.PA/Tis11^IE35/Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Tis11[+]/Scer\GAL4^wor.PA/Tis11^{ΔNot1.UAS.Tag:FLAG}/Tis11^IE35/Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage phenotype, enhanceable by Tis11[+]/Scer\GAL4^wor.PA/Tis11^{ΔNot1.UAS.Tag:FLAG}/Tis11^IE35/Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Scer\GAL4^wor.PA/Cul1^HM05197/Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage phenotype, enhanceable by Scer\GAL4^wor.PA/Cul1^HM05197/Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by numb^NP2301/numb¹⁵

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by numb^NP2301/numb¹⁵

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by insb^exA45

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage phenotype, enhanceable by insb^exA45

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by +/Df(3L)BSC377

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by +/Df(3L)BSC377

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Df(2L)ED94/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Df(2L)ED94/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Df(2L)ED105/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Df(2L)ED105/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Df(2L)BSC688/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Df(2L)BSC688/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Df(1)BSC625/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Df(1)BSC625/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Df(2R)BSC355/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Df(2R)BSC355/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by +/Df(2L)BSC292

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by +/Df(2L)BSC292

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by +/Df(3L)brm11

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by +/Df(3L)brm11

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Df(3L)BSC574/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Df(3L)BSC574/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by +/Df(3R)L127

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by +/Df(3R)L127

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Df(3R)Exel7327/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Df(3R)Exel7327/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by +/Df(2R)Exel7094

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by +/Df(2R)Exel7094

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by +/Df(2L)ED690

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by +/Df(2L)ED690

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by +/Df(2R)BSC161

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by +/Df(2R)BSC161

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Df(2R)ED1791/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Df(2R)ED1791/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Df(2R)BSC408/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Df(2R)BSC408/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Df(3L)ED4288/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Df(3L)ED4288/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by +/Df(3R)Exel9012

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by +/Df(3R)Exel9012

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Df(3R)DG2/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Df(3R)DG2/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Df(3R)crb-F89-4/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, enhanceable by Df(3R)crb-F89-4/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, enhanceable by Df(3R)BSC56/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by erm[+]/erm¹

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by brm[+]/brm²

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by mor[+]/mor¹

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by Scer\GAL4^GMR9D11/brm^{K804R.UAS.Tag:HA}

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by Scer\GAL4^wor.PA/brm^{K804R.UAS.Tag:HA}

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by klu^UAS.Tag:HA/Scer\GAL4^GMR9D11

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by dpn^UAS.cWa/Scer\GAL4^GMR9D11

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by E(spl)mγ-HLH^UAS.cLa/Scer\GAL4^GMR9D11

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by osa[+]/osa³⁰⁸

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by Apc2^g10/Apc2[+]

(Komori et al., 2014)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by CkIalpha[+]/CkIα^8B12

(Komori et al., 2014)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by sgg[+]/sgg^8E22

(Komori et al., 2014)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by Axn[+]/Axn^S044230

(Komori et al., 2014)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, enhanceable by Scer\GAL4^wor.PA/arm^{S10.UAS.Tag:MYC}

(Komori et al., 2014)

NOT Enhanced by

Statement

Reference

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, non-enhanceable by Uuuu\Ub^{AA.UAS.Tag:HA}/Scer\GAL4^wor.PA

(Komori et al., 2025)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage | increased number phenotype, non-enhanceable by Tis11[+]/Scer\GAL4^wor.PA/Tis11^{UAS.cKa.Tag:FLAG}/Tis11^IE35/Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | larval stage | increased number phenotype, non-enhanceable by Tis11[+]/Scer\GAL4^wor.PA/Tis11^{UAS.cKa.Tag:FLAG}/Tis11^IE35/Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, non-enhanceable by Scer\GAL4^GMR9D11/brm^{K804R.UAS.Tag:HA}

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, non-enhanceable by klu^UAS.Tag:HA/Scer\GAL4^GMR9D11

(Janssens et al., 2014)

Suppressed by

Statement

Reference

Usp5^leon-1, brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, suppressible by Scer\GAL4^GMR9D11/Usp5^UAS.Tag:FLAG

(Komori et al., 2025)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, suppressible by dpn[+]/dpn¹

(Komori et al., 2025)

brat^DG19310/brat¹¹, insb^exA45 has type II neuroblast | increased number | larval stage phenotype, suppressible by insb^cKa.GFP

(Komori et al., 2018)

brat^DG19310/brat¹¹, insb^exA45 has embryonic/larval optic lobe | larval stage phenotype, suppressible by insb^cKa.GFP

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | increased number | larval stage phenotype, suppressible by dpn[+]/dpn¹

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage phenotype, suppressible by dpn[+]/dpn¹

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | increased number | larval stage phenotype, suppressible by Df(3R)3450/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | increased number | larval stage phenotype, suppressible by Df(3R)Tl-P/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | increased number | larval stage phenotype, suppressible by Df(1)ED6565/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | increased number | larval stage phenotype, suppressible by +/Df(3L)BSC377

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage phenotype, suppressible by Df(1)ED6565/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage phenotype, suppressible by Df(3R)3450/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage phenotype, suppressible by Df(3R)Tl-P/+

(Komori et al., 2018)

brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage phenotype, suppressible by +/Df(3L)BSC377

(Komori et al., 2018)

Df(2R)ED1791/+, brat^DG19310/brat¹¹ has type II neuroblast | increased number | larval stage phenotype, suppressible | partially by Scer\GAL4^wor.PA/PAN2^UAS.Tag:V5/Scer\GAL80^ase.PU

(Komori et al., 2018)

Df(2R)ED1791/+, brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage phenotype, suppressible | partially by Scer\GAL4^wor.PA/PAN2^UAS.Tag:V5/Scer\GAL80^ase.PU

(Komori et al., 2018)

Tis11^IE35, brat^DG19310/brat¹¹ has type II neuroblast | increased number | larval stage phenotype, suppressible by dpn[+]/dpn¹

(Komori et al., 2018)

Tis11^IE35, brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage phenotype, suppressible by dpn[+]/dpn¹

(Komori et al., 2018)

brat^DG19310/brat¹¹, insb^exA45 has type II neuroblast | increased number | larval stage phenotype, suppressible by dpn[+]/dpn¹

(Komori et al., 2018)

brat^DG19310/brat¹¹, insb^exA45 has embryonic/larval optic lobe | larval stage phenotype, suppressible by dpn[+]/dpn¹

(Komori et al., 2018)

brat^DG19310/brat¹¹, erm[+]/erm¹ has type II neuroblast | somatic clone phenotype, suppressible by Scer\GAL4^GMR9D11/erm^UAS.Tag:HA

(Janssens et al., 2014)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, suppressible by Scer\GAL4^GMR9D11/erm^UAS.Tag:HA

(Janssens et al., 2014)

Apc2^g10/Apc2[+], brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, suppressible | partially by arm⁸/arm[+]

(Komori et al., 2014)

brat^DG19310/brat¹¹ has type II neuroblast | increased number | larval stage phenotype, suppressible by klu[+]/klu^unspecified

(Xiao et al., 2012)

NOT suppressed by

Statement

Reference

Df(2R)ED1791/+, brat^DG19310/brat¹¹ has type II neuroblast | increased number | larval stage phenotype, non-suppressible by PAN2^{D1039N.E1041Q.UAS.Tag:V5}/Scer\GAL4^wor.PA/Scer\GAL80^ase.PU

(Komori et al., 2018)

Df(2R)ED1791/+, brat^DG19310/brat¹¹ has embryonic/larval optic lobe | larval stage phenotype, non-suppressible by PAN2^{D1039N.E1041Q.UAS.Tag:V5}/Scer\GAL4^wor.PA/Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹ has type II neuroblast | increased number phenotype, non-suppressible by Scer\GAL4^GMR9D11/erm^UAS.Tag:HA

(Janssens et al., 2014)

Enhancer of

Statement

Reference

brat^DG19310/brat¹¹ is an enhancer of embryonic/larval optic lobe | larval stage phenotype of Cul1^HM05197, Scer\GAL4^wor.PA, Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹ is an enhancer of type II neuroblast | larval stage | increased number phenotype of Cul1^HM05197, Scer\GAL4^wor.PA, Scer\GAL80^ase.PU

(Komori et al., 2018)

brat^DG19310/brat¹¹ is an enhancer of type II neuroblast | larval stage | increased number phenotype of numb^NP2301/numb¹⁵

(Komori et al., 2018)

brat^DG19310/brat¹¹ is an enhancer of embryonic/larval optic lobe | larval stage | increased number phenotype of numb^NP2301/numb¹⁵

(Komori et al., 2018)

Other

Statement

Reference

brat^DG19310/brat¹¹, erm[+]/erm¹ has type II neuroblast | increased number | somatic clone phenotype

(Janssens et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of erm¹ enhances the supernumerary type II neuroblast phenotype seen in brat^DG19310/brat¹¹ mutants.

In contrast to brat^DG19310/brat¹¹ clones alone, clones originating from either a single ase+ immature Intermediate Neural Progenitor (INP) or INP that are also heterozygous for erm¹ contain an increased number of neuroblasts 'reverted clones'. This phenotype is reversed upon expression of erm^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR9D11. This rescue is seen using an insertion line of the driver that expressed in ase[-] INPs (P{GMR9D11-GAL4}2) and one that expresses in ase[+] INPs (P{GMR9D11-GAL4}attP2).

Expression of erm^{Scer\UAS.T:Ivir\HA1} under the control of an insertion of Scer\GAL4^GMR9D11 that expresses in ase[-] immature Intermediate Neural Progenitors (INPs) (P{GMR9D11-GAL4}2) suppresses the supernumerary neuroblast phenotype seen in brat^DG19310/brat¹¹ mutant larval brains. Expression of erm^{Scer\UAS.T:Ivir\HA1} using a line that expresses in ase[+] INPs (P{GMR9D11-GAL4}attP2) does not suppress the phenotype.

Expression of klu^{Scer\UAS.T:Ivir\HA1} under the control of an insertion of Scer\GAL4^GMR9D11 that expresses in ase[-] immature Intermediate Neural Progenitors (INPs) (P{GMR9D11-GAL4}2) enhances the supernumerary neuroblast phenotype seen in brat^DG19310/brat¹¹ mutant larval brains. No enhancement is seen when klu^{Scer\UAS.T:Ivir\HA1} is expressed using an insertion of Scer\GAL4^GMR9D11 that expresses in ase[+] INPs (P{GMR9D11-GAL4}attP2).

Expression of dpn^Scer\UAS.cWa under the control of an insertion of Scer\GAL4^GMR9D11 that expresses in ase[-] immature Intermediate Neural Progenitors (INPs) (P{GMR9D11-GAL4}2) enhances the supernumerary neuroblast phenotype seen in brat^DG19310/brat¹¹ mutant larval brains. A milder enhancement is seen when dpn^Scer\UAS.cWa is expressed using an insertion of Scer\GAL4^GMR9D11 that expresses in ase[+] INPs (P{GMR9D11-GAL4}attP2).

Expression of E(spl)mγ-HLH^Scer\UAS.cLa under the control of an insertion of Scer\GAL4^GMR9D11 that expresses in ase[-] immature Intermediate Neural Progenitors (INPs) (P{GMR9D11-GAL4}2) strongly enhances the supernumerary neuroblast phenotype seen in brat^DG19310/brat¹¹ mutant larval brains. A milder enhancement is seen when E(spl)mγ-HLH^Scer\UAS.cLa is expressed using an insertion of Scer\GAL4^GMR9D11 that expresses in ase[+] INPs (P{GMR9D11-GAL4}attP2).

One copy of osa³⁰⁸ enhances the supernumerary neuroblast phenotype seen in brat^DG19310/brat¹¹ mutants.

One copy of brm² enhances the supernumerary neuroblast phenotype seen in brat^DG19310/brat¹¹ mutants.

One copy of mor¹ enhances the supernumerary neuroblast phenotype seen in brat^DG19310/brat¹¹ mutants.

Expression of brm^{K804R.Scer\UAS.T:Ivir\HA1} under the control of an insertion of Scer\GAL4^GMR9D11 that expresses in ase[-] immature Intermediate Neural Progenitors (INPs) (P{GMR9D11-GAL4}2) enhances the supernumerary neuroblast phenotype seen in brat^DG19310/brat¹¹ mutant larval brains. Expression of brm^{K804R.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^wor.PA also enhances the phenotype. No enhancement is seen when brm^{K804R.Scer\UAS.T:Ivir\HA1} is expressed using an insertion of Scer\GAL4^GMR9D11 that expresses in ase[+] INPs (P{GMR9D11-GAL4}attP2).

(Janssens et al., 2014)

Expression of arm^{S10.Scer\UAS.T:Hsap\MYC} in type II neuroblasts or ase- immature intermediate neural progenitors (INPs) enhances the supernumerary neuroblast phenotype seen in brat^DG19310/brat¹¹ larval brains, whereas expression in ase+ immature INPs does not (different insertions of Scer\GAL4^GMR9D11 are used to drive expression in each case).

Expression of pan^ΔN.Scer\UAS in type II neuroblasts or ase- immature intermediate neural progenitors (INPs) suppresses the supernumerary neuroblast phenotype seen in brat^DG19310/brat¹¹ larval brains, whereas expression in ase+ immature INPs does not (different insertions of Scer\GAL4^GMR9D11 are used to drive expression in each case).

(Komori et al., 2014)

klu^unspecified/+ strongly suppresses the formation of supernumerary type II neuroblasts which is seen in brat¹¹/brat^DG19310 larval brains.

(Xiao et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

brat^DG19310

(Komori et al., 2025, Rajan et al., 2023, Komori et al., 2018, Janssens et al., 2014, Komori et al., 2014, Komori et al., 2014, Xiao et al., 2012, Gelbart, 2008.3.31)

Name Synonyms

Secondary FlyBase IDs

References (8)

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