FlyBase Allele Report: Dmel\klu[unspecified]

General Information

Symbol

Dmel\klu^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0057226

Feature type

allele

Associated gene

Dmel\klu

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

(FlyBase Curators, 2025-)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell death

(Rusconi et al., 2004)

Phenotype Manifest In

larval RP2 motor neuron

(Buescher and Chia, 1997)

ommatidium

(Rusconi et al., 2004)

Detailed Description

Statement

Reference

Hypomorphic mutations in klu result in a partial loss of cell death within the interommatidial lattice in the pupal eye. This results in on average 1.3 additional cells per ommatidial unit, which represents at least one-third of the cells that are normally removed by cell death. The number of additional cells does not change significantly from that seen for the hypomorphic mutations when an amorphic allele of klu in trans to a deficiency for the klu region is used.

(Rusconi et al., 2004)

Mutants show a duplication of the RP2 neurons. klu^unspecified Dr^unspecified double mutants show an additive phenotype with respect to gain of RP2 neurons.

(Buescher and Chia, 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

klu[+]/klu^unspecified is a suppressor of abnormal neuroanatomy | larval stage phenotype of brat^DG19310/brat¹¹

(Xiao et al., 2012)

klu^unspecified/klu^unspecified is a suppressor | somatic clone of abnormal neuroanatomy | larval stage phenotype of brat^k06028/brat¹¹

(Xiao et al., 2012)

klu^unspecified/klu^unspecified is a suppressor of abnormal neuroanatomy | larval stage phenotype of N^intra.GS.UAS, Scer\GAL4^wor.PA

(Xiao et al., 2012)

klu^unspecified/klu^unspecified is a suppressor of abnormal neuroanatomy | somatic clone | larval stage phenotype of N^intra.GS.UAS, Scer\GAL4^Act5C.PP

(Xiao et al., 2012)

klu[+]/klu^unspecified is a suppressor of visible phenotype of Ras85D^V12.sev

(Rusconi et al., 2004)

klu[+]/klu^unspecified is a suppressor of visible phenotype of hid^GMR.PG

(Rusconi et al., 2004)

klu[+]/klu^unspecified is a suppressor of visible phenotype of grim^GMR.PC

(Rusconi et al., 2004)

klu[+]/klu^unspecified is a suppressor of visible phenotype of rpr^GMR.PW

(Rusconi et al., 2004)

klu[+]/klu^unspecified is a suppressor of visible phenotype of Egfr^E1

(Rusconi et al., 2004)

Phenotype Manifest In

Enhancer of

Statement

Reference

klu[+]/klu^unspecified is an enhancer of ommatidium phenotype of Ras85D^V12.hs

(Rusconi et al., 2004)

Suppressor of

Statement

Reference

klu[+]/klu^unspecified is a suppressor of type II neuroblast | increased number | larval stage phenotype of brat^DG19310/brat¹¹

(Xiao et al., 2012)

klu^unspecified/klu^unspecified is a suppressor | somatic clone of type II neuroblast | increased number | larval stage phenotype of brat^k06028/brat¹¹

(Xiao et al., 2012)

klu^unspecified/klu^unspecified is a suppressor of type II neuroblast | increased number | larval stage phenotype of N^intra.GS.UAS, Scer\GAL4^wor.PA

(Xiao et al., 2012)

klu^unspecified/klu^unspecified is a suppressor of type I neuroblast | increased number | somatic clone | larval stage phenotype of N^intra.GS.UAS, Scer\GAL4^Act5C.PP

(Xiao et al., 2012)

klu[+]/klu^unspecified is a suppressor of ommatidium phenotype of Ras85D^V12.sev

(Rusconi et al., 2004)

klu[+]/klu^unspecified is a suppressor of ommatidium phenotype of hid^GMR.PG

(Rusconi et al., 2004)

klu[+]/klu^unspecified is a suppressor of ommatidium phenotype of grim^GMR.PC

(Rusconi et al., 2004)

klu[+]/klu^unspecified is a suppressor of ommatidium phenotype of rpr^GMR.PW

(Rusconi et al., 2004)

klu[+]/klu^unspecified is a suppressor of ommatidium phenotype of Egfr^E1

(Rusconi et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

klu^unspecified/+ strongly suppresses the formation of supernumerary type II neuroblasts which is seen in brat¹¹/brat^DG19310 larval brains.

The formation of supernumerary type II neuroblasts is suppressed in homozygous klu^unspecified type II neuroblast clones in brat¹¹/brat^k06028 larval brains.

Homozygosity for klu^unspecified significantly reduces the number of supernumerary neuroblasts and restores intermediate neural progenitor cells and ganglion mother cells in type II neuroblast clones in the larval brain expressing N^{intra.GS.Scer\UAS} under the control of Scer\GAL4^wor.PA (analysed 72 hours after clone induction).

Homozygosity for klu^unspecified significantly reduces the number of supernumerary neuroblasts per clone as well as the frequency of the clones containing more than one neuroblast in type I neuroblast clones in the larval brain expressing N^{intra.GS.Scer\UAS} under the control of Scer\GAL4^Act5C.PP.

(Xiao et al., 2012)

The eye phenotype caused by rpr^GMR.PW is mildly but consistently suppressed by klu^unspecified/+. The eye phenotype caused by grim^GMR.PC is mildly but consistently suppressed by klu^unspecified/+. klu^unspecified/+ strongly suppresses the eye phenotype caused by W^GMR.PG; the adult eye is dramatically increased in size and the pattern of the ommatidia is almost normal. klu^unspecified/+ suppresses the rough eye phenotype seen in Egfr^E1 adults. The rough eye phenotype caused by Ras85D^V12.sev is suppressed by klu^unspecified/+. klu^unspecified/+ enhances the extra cell phenotype seen in the retina of animals expressing Ras85D^V12.hs using heat shock at 24 hours after puparium formation; the double mutant animals have an average of 20.03 +/- 0.2 cells per ommatidial unit (compared to an average of 18.5 +/- 0.3 cells per ommatidial unit in animals expressing Ras85D^V12.hs at the same time in a klu⁺ background).

(Rusconi et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

klu^unspecified

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

Open Close