FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\numbS52F
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General Information
Symbol
Dmel\numbS52F
Species
D. melanogaster
Name
FlyBase ID
FBal0190604
Feature type
allele
Associated gene
Dmel\numb
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
    Nature of the Allele
    Allele class

    loss of function allele

    (Bhalerao et al., 2005)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Nucleotide substitution: C155T. Amino acid replacement: S52F.

    (Bhalerao et al., 2005)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    2L:9,460,578..9,460,578 [+]
    Nucleotide change:

    C9460578T

    Reported nucleotide change:

    C155T

    Amino acid change:

    S52F | numb-PA; S11F | numb-PB; S52F | numb-PD

    Reported amino acid change:

    S52F

    (Bhalerao et al., 2005)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In

        eo neuron | somatic clone

        (Bhalerao et al., 2005)

        external sensory organ | somatic clone

        (Bhalerao et al., 2005)

        external sensory organ precursor cell I | somatic clone

        (Bhalerao et al., 2005)

        external sensory organ precursor cell IIa | somatic clone | increased number

        (Bhalerao et al., 2005)

        external sensory organ precursor cell IIb | somatic clone

        (Bhalerao et al., 2005)

        hypodermal muscle cell of larval abdominal 9

        (Bhalerao et al., 2005)

        muscle cell of A1-7 dorsal acute muscle 1

        (Bhalerao et al., 2005)

        muscle cell of A1-7 dorsal oblique muscle 1

        (Bhalerao et al., 2005)

        muscle cell of abdominal 1 dorsal oblique muscle 1

        (Bhalerao et al., 2005)

        muscle cell of abdominal 2 dorsal acute muscle 1

        (Bhalerao et al., 2005)

        muscle cell of abdominal 2 dorsal oblique muscle 1

        (Bhalerao et al., 2005)

        muscle cell of abdominal 3 dorsal acute muscle 1

        (Bhalerao et al., 2005)

        muscle cell of abdominal 3 dorsal oblique muscle 1

        (Bhalerao et al., 2005)

        muscle cell of abdominal 4 dorsal acute muscle 1

        (Bhalerao et al., 2005)

        muscle cell of abdominal 4 dorsal oblique muscle 1

        (Bhalerao et al., 2005)

        muscle cell of abdominal 5 dorsal acute muscle 1

        (Bhalerao et al., 2005)

        muscle cell of abdominal 5 dorsal oblique muscle 1

        (Bhalerao et al., 2005)

        muscle cell of abdominal 6 dorsal acute muscle 1

        (Bhalerao et al., 2005)

        muscle cell of abdominal 6 dorsal oblique muscle 1

        (Bhalerao et al., 2005)

        muscle cell of abdominal 7 dorsal acute muscle 1

        (Bhalerao et al., 2005)

        muscle cell of abdominal 7 dorsal oblique muscle 1

        (Bhalerao et al., 2005)

        muscle cell of abdominal 8 dorsal oblique muscle 1

        (Bhalerao et al., 2005)

        sensory neuron | embryonic stage

        (Bhalerao et al., 2005)

        thecogen cell | somatic clone

        (Bhalerao et al., 2005)

        tormogen cell | somatic clone | increased number

        (Bhalerao et al., 2005)

        trichogen cell | somatic clone

        (Bhalerao et al., 2005)

        type II neuroblast | somatic clone | increased number

        (Ouyang et al., 2011)
        Detailed Description
        Statement
        Reference

        numbS52F mutant MARCM clones show a mild ectopic neuroblast formation phenotype in the type II neuroblast lineage.

        (Ouyang et al., 2011)

        Homozygous clones in the larval brain do not show overproliferation in the ase[+] or PAN neuroblast lineages.

        (Wirtz-Peitz et al., 2008)

        In numbS52F mutant clones, external sensory organs show cell-fate transformations: in 90.7%, four socket cells are present, in 7.4% there are two socket cells, one neuron and one sheath, and in 1.8% there are two hairs and two sockets. In embryos both maternally and zygotically mutant for numbS52F, 86% of all hemisegments show a complete loss of all sensory neurons. In numbS52F embryos, 100% of MP2 neuroblasts divide to generate two vMP2 cells, instead of one vMP2 and one dMP2 neuron. The division of GMC4-2a cells into RP2 and RP2sib cells is unaffected. In numbS52F stage 14-15 embryos, the DA1 precursors and DO1 precursors are absent, as FDA1 and FDO1 are transformed into their sibling cells. These embryos show no defects in the P2 lineage.

        (Bhalerao et al., 2005)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhanced by
        Suppressor of
        Phenotype Manifest In
        Enhanced by
        Suppressor of
        NOT Suppressor of
        Statement
        Reference

        numbS52F is a non-suppressor of RP2sib neuron phenotype of CycAC8LR1

        (Bhalerao et al., 2005)

        numbS52F is a non-suppressor of ganglion mother cell GMC4-2a phenotype of CycAC8LR1

        (Bhalerao et al., 2005)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Expression of NcdsRNA.Scer\UAS in a numbS52F background increases the number of ectopic neuroblasts.

        (Ouyang et al., 2011)

        The modest overproliferation of neuroblasts seen in the larval brain in animals expressing aPKCCAAXWT.Scer\UAS under the control of Scer\GAL41407 at 18[o]C is weakly suppressed by numbS52F/+.

        The overproliferation of larval brain neuroblasts seen in l(2)gl1/l(2)gl4 animals is weakly suppressed by numbS52F/+.

        (Wirtz-Peitz et al., 2008)

        In CycAC8LR1; numbS52F double mutant embryos, the GMC4-2a cell differentiates into only one RP2 neuron, instead of a RP2 neuron and a RP2sib neuron.

        (Bhalerao et al., 2005)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Fails to complement

        numb15

        (Bhalerao et al., 2005)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        numbS52F
        (Ouyang et al., 2011, Wirtz-Peitz et al., 2008, Wirtz-Peitz et al., 2008)
        Name Synonyms
        Secondary FlyBase IDs
          References (4)