FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\mol
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General Information
Symbol
Dmel\mol
Species
D. melanogaster
Name
moladietz
Annotation Symbol
CG4482
Feature Type
protein_coding_gene
FlyBase ID
FBgn0086711
Gene Model Status
Current
Stock Availability
21 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

l(2)35Bb, l(2)br3, BG:DS01219.1 , br3, numb-interacting protein

Key Links
Genomic Location
Cytogenetic map
35B7-35B8
Sequence location
Recombination map
2-50
RefSeq locus
NT_033779 REGION:14975747..14997559
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with FLYBASE:numb; FB:FBgn0002973
(Qin et al., 2004)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in intracellular protein localization
inferred from mutant phenotype
(Qin et al., 2004)
involved_in long-term memory
inferred from mutant phenotype
(Akalal et al., 2011)
involved_in response to oxidative stress
inferred from mutant phenotype
(Xie et al., 2010)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in protein transport
inferred from electronic annotation with InterPro:IPR018469
(InterPro Project Members, 2004-)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in basal part of cell
inferred from direct assay
(Qin et al., 2004)
located_in plasma membrane
inferred from direct assay
(Qin et al., 2004)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in endoplasmic reticulum membrane
inferred from electronic annotation with InterPro:IPR018469
(InterPro Project Members, 2004-)
is_active_in membrane
inferred from biological aspect of ancestor with PANTHER:PTN001259754
(GO Reference Genome Project, 2011-)
located_in membrane
inferred from electronic annotation with InterPro:IPR018469
(InterPro Project Members, 2004-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
l(2)35Bb
Rare survivors to adulthood in l(2)35Bb5/Df(2L)fn3.
Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\mol for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VJQ7)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.45

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
mol-RA
FBtr0080676
NM_135889
2210
474
mol-RC
FBtr0111014
NM_001042898
2455
474
mol-RD
FBtr0111015
NM_001042897
3012
474
mol-RF
FBtr0332520
NM_001042899
2073
474
mol-RG
FBtr0332521
NM_165094
2017
330
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
mol-PA
FBpp0080238
53.3
474
9.99
Q9VJQ7
NP_609733
AAF53425
mol-PC
FBpp0110313
53.3
474
9.99
Q9VJQ7
NP_001036363
ABI31317
mol-PD
FBpp0110314
53.3
474
9.99
Q9VJQ7
NP_001036362
ABI31316
mol-PF
FBpp0304790
53.3
474
9.99
Q9VJQ7
NP_001036364
ABI31318
mol-PG
FBpp0304791
37.4
330
10.04
Q7KT87
NP_723890
AAF53424
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

474 aa isoforms: mol-PA, mol-PC, mol-PD, mol-PF
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mol using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.04

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 1 -- 4
organism | ubiquitous
(Xie et al., 2010)
embryonic stage 4 -- 6
organism

Comment: apically cleared

(Fisher et al., 2012)
embryonic stage 5
organism | restricted
(Xie et al., 2010)
Additional Descriptive Data

mol transcripts are ubiquitous in early embryos until cellularization at which point they are excluded from epidermal cells. After cellularization they were undetectable. On northern blots mol transcripts are abundant in the first two hours of embryogenesis and then decline isgnificantly. Levels increase slightly at late embryonic stages and they are not detected in larval stages.

(Xie et al., 2010)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 2 -- 4
organism | restricted
(Xie et al., 2010)
Additional Descriptive Data

mol protein is highly expressed in preblastoderm embryos where it localizes to the cytoplasmic membrane as discrete dots. Levels decline at the syncytial blastoderm and cellularization stages.

(Xie et al., 2010)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in basal part of cell
inferred from direct assay
(Qin et al., 2004)
located_in plasma membrane
inferred from direct assay
(Qin et al., 2004)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\mol in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 20 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of mol
Transgenic constructs containing regulatory region of mol
Aberrations (Deficiencies and Duplications) ( 197 )
Inferred from experimentation ( 197 )
Gene disrupted in
Df(2L)64j
(Furukawa et al., 1992, Ashburner, 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Df(2L)A47
(McNabb et al., 1996)
Df(2L)A48
(McNabb et al., 1996, Roote et al., 1996, Fossett et al., 1994, Gubb et al., 1990, Grau et al., 1984, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A63
(McNabb et al., 1996)
Df(2L)A72
(McNabb et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A215
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A217
(McNabb et al., 1996)
Df(2L)A220
(McNabb et al., 1996, Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A245
(McNabb et al., 1996)
Df(2L)A246
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A260
(McNabb et al., 1996)
Df(2L)A263
(Furukawa et al., 1992, Ashburner et al., 1982)
Df(2L)A264
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A266
(McNabb et al., 1996)
Df(2L)A267
(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A337
(Fossett et al., 1994)
Df(2L)A376
(Fossett et al., 1994, Ashburner, 1982, Ashburner et al., 1982)
Df(2L)A377
(Ashburner, 1982, Ashburner et al., 1982)
Df(2L)A400
(Roote et al., 1996, Fossett et al., 1994, Ashburner, 1982, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A445
(McNabb et al., 1996)
Df(2L)Adh-nBR55
(Fossett et al., 1990)
Df(2L)Adh-nBR101
(Fossett et al., 1994)
Df(2L)Adh-nBR102
(Roote et al., 1996, Fossett et al., 1994)
Df(2L)Adh-nBR103
(Fossett et al., 1994)
Df(2L)Adh-nBR105
(Fossett et al., 1994)
Df(2L)Adh-nBR106
(Fossett et al., 1994)
Df(2L)Adh-nBR107
(Fossett et al., 1994)
Df(2L)Adh-nBR111
(Fossett et al., 1990)
Df(2L)Adh-nBR118
(Fossett et al., 1994)
Df(2L)Adh-nBR120
(Fossett et al., 1994)
Df(2L)Adh-nBR122
(Fossett et al., 1994)
Df(2L)Adh-nBR125
(Fossett et al., 1994)
Df(2L)Adh-nBR126
(Fossett et al., 1994)
Df(2L)Adh-nBR128
(Fossett et al., 1994)
Df(2L)Adh-nBR129
(Fossett et al., 1994)
Df(2L)Adh-nBR130
(Fossett et al., 1994)
Df(2L)Adh-nBR131
(Fossett et al., 1994)
Df(2L)ARR1
(Roote et al., 1996, Furukawa et al., 1992, Ashburner, 1982)
Df(2L)b84a1
(McNabb et al., 1996)
Df(2L)b84a3
(Furukawa et al., 1992)
Df(2L)b84h50
(Furukawa et al., 1992)
Df(2L)BSC254
(Christensen and Cook, 2007.3.22)
Df(2L)do1
(Ashburner, 1982)
Df(2L)el28
(Furukawa et al., 1992)
Df(2L)el80f1
(Ashburner et al., 1983)
Df(2L)Exel7061
(Ryder, 2004.4.26)
Df(2L)Exel8033
(Ryder, 2004.4.26)
Df(2L)fn1
(Grau et al., 1984, Ashburner et al., 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Df(2L)fn2
(McNabb et al., 1996)
Df(2L)fn3
(Ashburner et al., 1999, Roote et al., 1996, Ashburner, 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Df(2L)fn5
(Furukawa et al., 1992, Ashburner et al., 1982, O'Donnell et al., 1977)
Df(2L)fn7
(McNabb et al., 1996)
Df(2L)fn12
(Ashburner et al., 1982, Woodruff and Ashburner, 1979)
Df(2L)fn15
(Ashburner et al., 1982, O'Donnell et al., 1977)
Df(2L)fn26
(Ashburner et al., 1982)
Df(2L)fn27
(Ashburner, 1982, Ashburner et al., 1982, Ashburner et al., 1982, O'Donnell et al., 1977)
Df(2L)fn30
(Ashburner et al., 1982, O'Donnell et al., 1977)
Df(2L)fn31
(Ashburner, 1982, Ashburner et al., 1982, O'Donnell et al., 1977)
Df(2L)fn36
(McNabb et al., 1996)
Df(2L)fn52
(McNabb et al., 1996)
Df(2L)GT5
(Gubb et al., 1990)
Df(2L)k15711
(Ashburner et al., 1999, Roote, 1998.11.16)
Df(2L)n78l3
(Ashburner et al., 1982)
Df(2L)noc10
(McNabb et al., 1996)
Df(2L)noc13
(McNabb et al., 1996)
Df(2L)osp18
(McNabb et al., 1996)
Df(2L)osp29
(McNabb et al., 1996, Roote, 1996.8, Roote et al., 1996, Furukawa et al., 1992, Chia et al., 1985, Grau et al., 1984, Ashburner et al., 1982)
Df(2L)Sco7
(Ashburner et al., 1983)
Df(2L)Scorv4
(Ashburner et al., 1990, Ashburner et al., 1983, Woodruff and Ashburner, 1979)
Df(2L)Scorv23
(Grau et al., 1984, Ashburner et al., 1983, Ashburner, 1982)
Df(2L)TE35B-1
(Gubb et al., 1985)
Df(2L)TE35B-2
(Gubb et al., 1985)
Df(2L)TE35B-5
(Gubb et al., 1985)
Df(2L)TE35B-6
(Gubb et al., 1985)
Df(2L)TE35B-9
(McNabb et al., 1996)
Df(2L)TE35B-11
(McNabb et al., 1996)
Df(2L)TE35B-15
(McNabb et al., 1996)
Df(2L)TE35B-54L
(Roote et al., 1996)
Df(2L)TE35BC-4
(McNabb et al., 1996, Roote, 1996.8, Roote et al., 1996, Gubb et al., 1984, Ashburner, 1982, Ashburner et al., 1982)
Df(2L)TE35BC-6
(Gubb et al., 1984)
Df(2L)TE35BC-7
(Furukawa et al., 1992, Gubb et al., 1984)
Df(2L)TE35BC-8
(Gubb et al., 1984)
Df(2L)TE35BC-23
(Gubb et al., 1984)
Df(2L)TE35BC-28
(McNabb et al., 1996, Roote et al., 1996, Furukawa et al., 1992, Gubb et al., 1984)
Df(2L)TE35BC-29
(Gubb et al., 1984)
Df(2L)TE35BC-31
(Gubb et al., 1984)
Df(2L)TE35BC-34
(Roote, 1996.8, Roote et al., 1996, Gubb et al., 1984)
Df(2L)TE35BC-35
(McNabb et al., 1996, Roote et al., 1996, Gubb et al., 1984)
Df(2L)TE35D-5
(Roote et al., 1996)
Df(2L)TE35D-10
(Roote et al., 1996)
Df(2L)TE35D-12
(Roote et al., 1996)
Df(2L)TE35D-23
(Roote et al., 1996)
Df(2L)W
(McNabb et al., 1996)
In(2L)75c
(Grau et al., 1984, Ashburner, 1982, Woodruff and Ashburner, 1979)
In(2L)C158LScorv11R
(Roote et al., 1996, Ashburner and Harrington, 1984, Ashburner et al., 1983)
In(2L)C158LScorv17R
(Roote et al., 1996, Ashburner and Harrington, 1984, Ashburner et al., 1983)
In(2L)TE35B-13
(Gubb et al., 1985)
In(2LR)noc4LScorv9R
(Ashburner and Harrington, 1984)
In(2LR)TE35B-6LScorv9R
(Ashburner and Harrington, 1984)
T(2;3)TE35B-2a
(Chia et al., 1985)
T(2;3)TE35B-3DG16P
(Chia et al., 1985)
T(Y;2)A80DR15P
(Ashburner et al., 1982, Woodruff and Ashburner, 1979)
Tp(2;2)A446
(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Ts(2Lt;3Lt)Mpe+Ts(2Rt;3Rt)G16
(Chia et al., 1985)
Ts(2Lt;3Lt)TE35B-4+Ts(2Rt;3Rt)Scorv13
(Chia et al., 1985, Ashburner and Harrington, 1984)
Ts(2Lt;3Lt)TE35BC-3+Ts(2Rt;3Rt)Scorv13
(McNabb et al., 1996, Roote et al., 1996, Ashburner and Harrington, 1984, Ashburner et al., 1983)
Ts(Y;2Lt)el4+Ts(YSt;2Rt)R15
(Roote et al., 1996, Ashburner et al., 1982)
Gene duplicated in
Dp(2;1)Scorv23
(Grau et al., 1984, Ashburner et al., 1983, Ashburner, 1982)
Dp(2;2)GYL
(Ashburner, 1982)
Dp(2;2)GYS
(Ashburner, 1982)
Dp(2;2)TE35B-54L
(Roote et al., 1996)
Dp(2;3)osp3
(Roote et al., 1996)
In(2L)C163.41LC158R
(Roote et al., 1996, Ashburner, 1982, Ashburner et al., 1982)
In(2L)Scorv17LC158R
(Ashburner, 1982)
Ts(YLt;2Lt)R15+Ts(Y;2Rt)el4
(Roote et al., 1996)
Ts(YLt;2Lt)R15+Ts(Y;2Rt)TE35B-18
(Roote et al., 1996)
Ts(YLt;2Lt)R15+Ts(YSt;2Rt)A80
(Roote et al., 1996)
Gene not disrupted in
Df(2L)A47
(Roote, 1996.8, Roote et al., 1996, Fossett et al., 1994, Gubb et al., 1990, Ashburner et al., 1982)
Df(2L)A63
(Roote, 1996.8, Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A178
(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A217
(Roote, 2000.7.3, Roote, 1996.8, Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A245
(Roote, 1996.8, Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A260
(Roote, 1996.8, Ashburner et al., 1982)
Df(2L)A266
(Roote, 1996.8, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A379
(McNabb et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A445
(Roote, 1996.8, Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)Adh-nBR41
(Fossett et al., 1990)
Df(2L)Adh-nBR100
(Roote, 1996.1.11, Roote, 1996.8, Fossett et al., 1994)
Df(2L)Adh-nBR117
(Fossett et al., 1994)
Df(2L)Adh-nBR119
(Roote, 1996.1.11, Roote, 1996.8, Fossett et al., 1994)
Df(2L)Adh-nBR121
(Roote, 1996.1.11, Roote, 1996.8, Fossett et al., 1994)
Df(2L)Adh-nBR127
(Roote, 1996.1.11, Roote, 1996.8, Fossett et al., 1994)
Df(2L)b75
(Gubb et al., 1990, Woodruff and Ashburner, 1979)
Df(2L)b80e3
(Roote et al., 1996, Ashburner et al., 1982)
Df(2L)b81a1
(Roote et al., 1996, Ashburner et al., 1982)
Df(2L)b83d29a
(Roote et al., 1996)
Df(2L)b84a1
(Roote, 1996.8)
Df(2L)b84a2
(Roote et al., 1996)
Df(2L)b84a4
(McNabb et al., 1996, Roote et al., 1996)
Df(2L)b84a7
(Furukawa et al., 1992)
Df(2L)b84a8
(McNabb et al., 1996)
Df(2L)b88c25
(Roote, 2000.7.3, Roote, 1996.8)
Df(2L)b88h49
(Roote et al., 1996)
Df(2L)b89e68
(Roote, 2000.7.3)
Df(2L)el14
(Roote et al., 1996)
Df(2L)el77
(McNabb et al., 1996, Woodruff and Ashburner, 1979)
Df(2L)fn2
(Roote, 1996.8, Roote et al., 1996, Grau et al., 1984, Ashburner et al., 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Df(2L)fn7
(Roote, 1996.8, Ashburner, 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Df(2L)fn36
(Roote, 1996.8, Ashburner et al., 1982, O'Donnell et al., 1977)
Df(2L)fn52
(Roote, 1996.8)
Df(2L)GT4
(McNabb et al., 1996, Gubb et al., 1990)
Df(2L)noc10
(Roote, 1996.8)
Df(2L)noc13
(Roote, 1996.8)
Df(2L)noc20
(McNabb et al., 1996)
Df(2L)osp144
(McNabb et al., 1996, Roote et al., 1996, Ashburner et al., 1982)
Df(2L)osp201
(McNabb et al., 1996)
Df(2L)PA4
(Ashburner et al., 1983)
Df(2L)rd9
(Furukawa et al., 1992)
Df(2L)Sco-1
(Ashburner, 1982)
Df(2L)Scorv10
(Grau et al., 1984, Ashburner et al., 1983)
Df(2L)Scorv14
(Ashburner et al., 1983)
Df(2L)Scorv16
(Grau et al., 1984, Ashburner et al., 1983)
Df(2L)Scorv18
(Ashburner et al., 1983)
Df(2L)Scorv19
(Grau et al., 1984, Ashburner et al., 1983)
Df(2L)Scorv25
(Grau et al., 1984, Ashburner et al., 1983)
Df(2L)SS1
(Grau et al., 1984)
Df(2L)TE35B-3
(Gubb et al., 1985)
Df(2L)TE35B-4
(Gubb et al., 1985)
Df(2L)TE35B-7
(Roote et al., 1996, Gubb et al., 1985)
Df(2L)TE35B-8
(McNabb et al., 1996, Roote et al., 1996, Gubb et al., 1985)
Df(2L)TE35B-9
(Roote, 1996.8, Gubb et al., 1985)
Df(2L)TE35B-10
(Gubb et al., 1985)
Df(2L)TE35B-11
(Roote, 1996.8, Roote et al., 1996, Gubb et al., 1985)
Df(2L)TE35B-12
(Roote et al., 1996, Gubb et al., 1985)
Df(2L)TE35B-15
(Roote, 1996.8, Gubb et al., 1985)
Df(2L)TE35B-48
(McNabb et al., 1996, Roote, 1996.8, Gubb et al., 1986)
Df(2L)TE35B-54
(McNabb et al., 1996, Gubb et al., 1986)
Df(2L)TE35B-300
(Roote et al., 1996)
Df(2L)TE35BC-1
(Gubb et al., 1984, Ashburner, 1982)
Df(2L)TE35BC-3
(Grau et al., 1984, Gubb et al., 1984, Ashburner, 1982, Ashburner et al., 1982)
Df(2L)TE35BC-24
(Iyengar et al., 1999, Gubb et al., 1984)
Df(2L)TE35D-2
(Furukawa et al., 1992)
Df(2L)TE35D-6
(Furukawa et al., 1992)
Df(2L)TE35D-13
(Furukawa et al., 1992)
Df(2L)TE35D-15
(Furukawa et al., 1992)
Df(2L)TE35D-18
(Furukawa et al., 1992)
Df(2L)W
(Roote, 1996.8, Ashburner et al., 1982, Woodruff and Ashburner, 1979)
Dp(2;2)Cam12
(Roote et al., 1996)
In(2L)75cLC158.1R
(Woodruff and Ashburner, 1979)
In(2L)C158
(McNabb et al., 1996, Roote et al., 1996)
In(2L)osp22
(McNabb et al., 1996)
In(2L)osp59
(McNabb et al., 1996)
In(2LR)D20Lnoc4R
(Roote et al., 1996)
In(2LR)el6LA379R
(Roote et al., 1996)
T(2;3)H47
(McNabb et al., 1996)
T(2;3)Mpe
(McNabb et al., 1996)
T(2;3)osp90
(McNabb et al., 1996)
T(2;3)Scorv7
(Ashburner and Harrington, 1984, Grau et al., 1984, Ashburner et al., 1983, Woodruff and Ashburner, 1979)
T(2;3)TE35BC-3
(McNabb et al., 1996, Roote et al., 1996)
T(Y;2)a15
(Davis et al., 1997)
T(Y;2)J165DP58P
(Woodruff and Ashburner, 1979)
T(Y;2)R15DJ165P
(Woodruff and Ashburner, 1979)
Tp(2;3)osp3
(McNabb et al., 1996)
Tp(2;3)pb3
(McNabb et al., 1996)
Ts(2Lt;3Lt)dpps19+Ts(2Rt;3Rt)el24
(Roote et al., 1996)
Ts(2Lt;3Lt)TE35B-28+Ts(2Rt;3Rt)osp90
(Roote et al., 1996)
Ts(2Lt;3Rt)GT10+Ts(2Rt;3Lt)TE35B-209
(Roote et al., 1996)
Ts(Y;2Lt)el4+Ts(YSt;2Rt)A80
(Roote et al., 1996)
Ts(Y;2Lt)GT2+Ts(YSt;2Rt)A80
(Roote et al., 1996)
Gene not duplicated in
Dp(2;2)Adh3
(Ashburner, 1982)
In(2LR)TE35B-226LDTD128R
(Roote et al., 1996)
Ts(2Lt;4Lt)TE35B-101+Ts(2Rt;4Rt)GT6
(Roote et al., 1996)
Ts(Y;2Lt)TE35B-18+Ts(YSt;2Rt)A80
(Roote et al., 1996)
Ts(YLt;2Lt)A80+Ts(Y;2Rt)el4
(Roote et al., 1996)
Ts(YLt;2Lt)A80+Ts(YLt;2Rt)G74
(Roote et al., 1996)
Inferred from location ( 6 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal (with Df(2L)BSC254)
lethal (with Df(2R)Exel6066)
lethal (with mole02670)
lethal (with molSH1330)
lethal | chemical conditional, with Scer\GAL4da.G32
lethal | pupal stage | heat sensitive, with Scer\GAL4da.G32
lethal | recessive
lethal - all die before end of first instar larval stage
lethal - all die before end of pupal stage | heat sensitive, with Scer\GAL4αTub84B.PL
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
viable, with Scer\GAL4αTub84B.PL
Sterility
Allele
fertile, with Scer\GAL4αTub84B.PL
Other Phenotypes
Allele
abnormal developmental rate | embryonic stage
abnormal developmental rate | embryonic stage | germline clone
abnormal developmental rate | first instar larval stage
abnormal developmental rate | first instar larval stage | germline clone
abnormal feeding behavior | first instar larval stage | germline clone
abnormal learning
abnormal memory
abnormal oxidative stress response, with Scer\GAL4da.G32
abnormal oxidative stress response, with Scer\GAL4αTub84B.PL
abnormal stress response | adult stage
abnormal stress response | adult stage, with Scer\GAL4rn-GAL4-5
chemical sensitive, with Scer\GAL4da.G32
short lived, with Scer\GAL4da.G32
some die during first instar larval stage
some die during pupal stage | heat sensitive, with Scer\GAL4αTub84B.PL
visible | adult stage
visible | adult stage, with Scer\GAL4rn-GAL4-5
Phenotype manifest in
Allele
embryo | germline clone
embryonic/larval gut | germline clone
larval tracheal system | germline clone
mitochondrion, with Scer\GAL4da.G32
wing
wing, with Scer\GAL4da.G32
wing, with Scer\GAL4rn-GAL4-5
wing, with Scer\GAL4αTub84B.PL
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (2)
Hsap\DUOXA1
12 of 14
Yes
Yes
Hsap\DUOXA2
11 of 14
No
Yes
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (2)
Rnor\Duoxa1
12 of 14
Yes
Yes
Rnor\Duoxa2
11 of 14
No
Yes
Mus musculus (laboratory mouse) (2)
Mmus\Duoxa1
12 of 14
Yes
Yes
Mmus\Duoxa2
10 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\duoxa1
9 of 13
Yes
Yes
Xtro\LOC101733132
6 of 13
No
Yes
Danio rerio (Zebrafish) (1)
Drer\duox2
8 of 14
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\doxa-1
11 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (2)
Agam\AgaP_AGAP009976
7 of 12
Yes
Yes
Agam\AgaP_AGAP009977
3 of 12
No
Yes
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:mol. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    DUOXA2; dual oxidase maturation factor 2
    model of  thyroid dyshormonogenesis 5
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    DUOXA1; dual oxidase maturation factor 1
    12 of 14
    612771
        DUOXA2; dual oxidase maturation factor 2
        11 of 14
        612772
         
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Summary of Genetic Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        mol
        suppressible
        puc
        (Khan et al., 2017)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        mxc
        enhanceable
        mol
        (Kinoshita et al., 2022)
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyBase
        External Links
        External Data
        Linkouts
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2L
        Recombination map
        2-50
        Cytogenetic map
        35B7-35B8
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        35B7-35B8
        Limits computationally determined from genome sequence between P{EP}elBEP2039&P{PZ}osprJ571 and P{lacW}Su(H)k07904
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        35B7-35B7
        (Oh et al., 2003)
        35B6-35B7
        (determined by in situ hybridisation)
        (Ashburner et al., 1999, Spradling et al., 1999)
        35B6-35B7
        (BDGP Project Members, 1994-1999)
        Experimentally Determined Recombination Data
        Location

        2-50

        (FlyBase, 2016)

        2-47.7

        (Comeron et al., 2012)
        Left of (cM)
        (Woodruff and Ashburner, 1979)
        Right of (cM)
        (Woodruff and Ashburner, 1979)
        Notes
        Stocks and Reagents
        Stocks (21)
        Genomic Clones (29)
        cDNA Clones (59)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           
            Other Comments

            Identification: as a protein that binds the numb PTB domain.

            (Qin et al., 2004)

            mol and numb proteins are colocalised at the plasma membrane in Schneider 2 cells.

            (Qin et al., 2004)

            Inhibition of mol expression in Schneider 2 cells by RNA interference releases numb protein from the plasma membrane to the cytosol.

            (Qin et al., 2004)

            1 allele of mol recovered in a P-insertion screen.

            (Oh et al., 2003)
            Relationship to Other Genes
            Source for database merge of

            Source for merge of: BG:DS01219.1 CG15268

            (Crosby and Roote, 2006.3.2, FlyBase, 1996-)
            Additional comments

            Source for merge of BG:DS01219.1 CG15268 was a shared cDNA ( date:010720 ).

            (Crosby and Roote, 2006.3.2, FlyBase, 1996-)

            The "l(2)35Bb" complementation group was previously assigned to the CG31834 annotation (also known as " BG:DS00929.16 ", see FBrf0111326) in FlyBase. However, the CG31834 annotation has been eliminated in release 5.1 of the genome annotation, and the CG4482 annotation (corresponding to mol) on the opposite strand has been extended at the 5'end, such that it overlaps the region of the genome where the CG31834 annotation used to be. This together with complementation data from Crosby and Roote, 2006.3.2, personal communication to FlyBase suggests that the "l(2)35Bb" complementation group actually corresponds to the mol locus.

            (FlyBase Genome Annotators, 2006)

            " BG:DS01219.1 " may correspond to "l(2)35Bb".

            (Ashburner et al., 1999.10.12)
            Nomenclature History
            Source for database identify of

            Source for identity of: BG:DS01219.1 CG4482

            (Kodira, 1999.11)
            Nomenclature comments
            Etymology

            Given the name "moladietz", after one of Pavlov's dogs.

            (Dubnau et al., 2003)
            Synonyms and Secondary IDs (23)
            Reported As
            Symbol Synonym
            35Bb
            (Roote, 1998.11.16, Roote, 1997.6.6)
            B1
            (O'Donnell et al., 1977)
            BG:DS01219.1
            (Giot et al., 2003, Ashburner et al., 1999, Ashburner et al., 1999, Ashburner et al., 1999.10.12)
            CG15268
            CG4482
            (National Institute of Genetics Fly Stocks, 2022-, Palu and Thummel, 2016, Schertel et al., 2013, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Berger et al., 2008, Qin et al., 2004)
            Mol
            (Pinal et al., 2019, Tokusumi et al., 2012)
            NIP
            (Xie et al., 2010)
            br3
            (Furukawa et al., 1992, Gubb et al., 1985, Ashburner and Harrington, 1984, Grau et al., 1984)
            l(2)35Bb
            (Christensen and Cook, 2007.3.22, Roote, 2000.6.13, Roote, 2000.7.3, Ashburner et al., 1999, Ashburner et al., 1999, Ashburner et al., 1999.10.12, Iyengar et al., 1999, Spradling et al., 1999, McNabb et al., 1996, Roote, 1996.1.11, Roote, 1996.8, Roote et al., 1996, Spradling et al., 1995, BDGP Project Members, 1994-1999, Fossett et al., 1990, Gubb et al., 1990, Gubb et al., 1988)
            l(2)SH1330
            l(2)SH2 1330
            (Oh et al., 2002.3.25)
            l(2)br23
            (Woodruff and Ashburner, 1979)
            l(2)br3
            (The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Gubb et al., 1986, Gubb et al., 1984, Ashburner et al., 1983, Ashburner, 1982, Ashburner et al., 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979)
            l35Bb
            (Fossett et al., 1994)
            mol
            (Klemm et al., 2025, Sutton et al., 2024, National Institute of Genetics Fly Stocks, 2022-, Worley and Hariharan, 2022, Fox et al., 2020, Morata and Calleja, 2020, Lee et al., 2018, Pinal et al., 2018, Gene Disruption Project members, 2016-, Panda et al., 2015, Zhang et al., 2015, Ashwal-Fluss et al., 2014, Schertel et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Pezzulo et al., 2012, Reid et al., 2012)
            nip
            (Xie et al., 2010, Qin et al., 2004)
            Name Synonyms
            lethal (2) 35Bb
            lethal (2) SH1330
            lethal 23 in the black-reduced region
            (Woodruff and Ashburner, 1979)
            lethal 3 in the black-reduced region
            (Woodruff and Ashburner, 1979)
            lethal group B1
            (O'Donnell et al., 1977)
            moladietz
            (Reid et al., 2012, Berger et al., 2008, Dubnau et al., 2003, Tully and Dubnau, 2003)
            numb-interacting protein
            (Xie et al., 2010, Qin et al., 2004)
            Secondary FlyBase IDs
            • FBgn0065471
            • FBgn0051834
            • FBgn0040981
            • FBgn0027871
            • FBgn0001972
            • FBgn0028528
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            External Crossreferences and Linkouts ( 52 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            FlyMine - An integrated database for Drosophila genomics
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            MIST (protein-protein) - An integrated Molecular Interaction Database
            References (108)