FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Aberration: Dmel\Df(2L)fn2
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General Information
Symbol
Df(2L)fn2
Species
D. melanogaster
Name
Deficiency (2L) formaldehyde induced
FlyBase ID
FBab0001815
Feature type
chromosomal_deletion
Computed Breakpoints include

35A4-35B1;35B2

Features within 35A4--35B2
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
formaldehyde
(McNabb et al., 1996, Grau et al., 1984, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Gubb et al., 1997, McNabb et al., 1996, Roote et al., 1996, Gubb et al., 1990, Gubb et al., 1986, Ashburner et al., 1983, Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Breakpoints

35A1-35A2;35B6-35B7

(O'Donnell et al., 1977)

35A3;35B2-35B4

(Gubb et al., 1986, Ashburner et al., 1983, Ashburner et al., 1982, Woodruff and Ashburner, 1979)

35A3;35B2

(Gubb et al., 1997, McNabb et al., 1996, Roote et al., 1996, Gubb et al., 1990)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

pu << bk1 << l(2)35Ab << Adh << bk2 << mol

Genetic mapping information
Comments
Comments on Cytology

Left limit of break 1 from non-inclusion of elB (FBrf0091422) Right limit of break 1 from inclusion of elA (FBrf0030161) Left limit of break 2 from inclusion of Adh (FBrf0030161) Right limit of break 2 from polytene analysis (FBrf0051930)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Genes NOT Deleted / Disrupted
Complementation Data
 
Adc
(Ashburner et al., 1982, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Ankrd49
(Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Arpc1
(Ashburner et al., 1982, Woodruff and Ashburner, 1979)
BicC
(Grau et al., 1984)
CIAPIN1
(Ashburner et al., 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
ck
(Grau et al., 1984, Ashburner et al., 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Cul3
(Ashburner et al., 1982, Ashburner et al., 1982)
CycE
(Grau et al., 1984, Ashburner et al., 1982, Ashburner et al., 1982)
DCTN5-p25
(Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
elB
(Davis et al., 1997, Roote et al., 1996)
l(2)34Db
(Ashburner et al., 1982)
l(2)34Fc
(Roote et al., 1996, Ashburner et al., 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
l(2)34Fd
(Roote et al., 1996, Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
lace
(Grau et al., 1984, Ashburner et al., 1982, Ashburner et al., 1982)
mol
(Roote, 1996.8, Roote et al., 1996, Grau et al., 1984, Ashburner et al., 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
ms(2)34Fe
(Roote et al., 1996)
NimA
(Ashburner et al., 1982, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
NimC3
(Ashburner et al., 1982)
Pburs
(Davis et al., 1997, Roote et al., 1996, Grau et al., 1984, Ashburner et al., 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Pgant35A
(Roote et al., 1996, Ashburner et al., 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
PolD3
(Grau et al., 1984, Ashburner et al., 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
PolG1
(Ashburner et al., 1982, Woodruff and Ashburner, 1979)
PolG2
(Ashburner et al., 1982, Woodruff and Ashburner, 1979)
Polr2C
(Ashburner et al., 1982, Woodruff and Ashburner, 1979)
rk
(Ashburner et al., 1982, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Rnmt
(Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Smg5
(Ashburner et al., 1982)
sna
(Grau et al., 1984, Ashburner et al., 1982, Ashburner et al., 1982)
Sos
(Ashburner et al., 1982, Woodruff and Ashburner, 1979)
stc
(Grau et al., 1984, Ashburner et al., 1982, Ashburner et al., 1982)
Su(H)
(Grau et al., 1984, Ashburner et al., 1982, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Thg
(Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
wb
(Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
wor
(Grau et al., 1984, Ashburner et al., 1982, Ashburner et al., 1982)
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (0)
    If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
    In these cases, there will be no "Export to Hitlist" button to the left.
    Phenotypic Data
    In combination with other aberrations

    Df(2L)fn2/Df(2L)b83d29a adults have a weak crippled legs phenotype. Df(2L)fn2/Df(2L)b84a2 animals usually die as pharate adults, rare escapers have crippled legs and show an "elbow" phenotype.

    (Davis et al., 1997)

    Viable in combination with In(2L)TE35B-1, T(2;3)TE35B-3, In(2L)TE35B-8, In(2L)TE35B-11, In(2LR)TE35B-15, In(2L)TE35B-16, T(2;3)TE35B-25, T(2;3)TE35B-26, In(2L)TE35B-27, T(2;3)TE35B-28, T(2;4)TE35B-50, In(2L)TE35B-53, Tp(2;2)TE35B-54, In(2L)TE35B-55, In(2L)TE35B-56, T(2;3)TE35B-58, T(2;3)TE35B-200, T(Y;2)TE35B-201, In(2LR)TE35B-205, T(Y;2)TE35B-206, T(2;3)TE35B-207, T(2;3)TE35B-208, T(2;3)TE35B-209, In(2L)TE35B-210, T(Y;2)TE35B-211, T(2;3)TE35B-212, T(Y;2)TE35B-213, T(2;4)TE35B-214, T(2;3)TE35B-215, T(2;3)TE35B-216, T(1;2)TE35B-217, T(2;3)TE35B-218, In(2)TE35B-219, In(2L)TE35B-220, In(2LR)TE35B-222, In(2LR)TE35B-223, T(2;3)TE35B-224, In(2L)TE35B-225, In(2LR)TE35B-226, In(2L)TE35B-227 and T(2;3)TE35B-230, producing flies with a noc phenotype.

    (Gubb et al., 1997)

    Strongly suppresses the zeste phenotype in a z1 w11E4; Tp(1;2)TE35B homologue.

    (Gubb et al., 1990)
    NOT in combination with other aberrations

    Chromosome acts as a strong trans-suppressor of a physical interaction between tandemly duplicated copies of w+, an interaction that is required for the suppression of genes by z1.

    (Gubb et al., 1990)

    Homozygous embryos gastrulate normally and usually appear morphologically normal at the end of embryogenesis (a few show weak pigmentation).

    (Grau et al., 1984)
    Stocks (2)
    Notes on Origin
    Discoverer

    Sofer.

     

    Selected as ADH null on 1-penten-3-ol.

    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     

    The Df(2L)fn2 chromosome may act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion), but the eye colour phenotype in the presence of Df(2L)fn2 overlaps the eye colour phenotype in a wild-type background so it cannot be unequivocally demonstrated that the deficiency chromosome uncovers a suppressor of telomeric silencing. In addition, any suppression is a false positive result (the suppressor is not within the bounds of the deficient region) because the region of the deficiency is covered by one or more nonsuppressing deficiencies.

    (Mason et al., 2004)

    Reported to delete Adhr in error; see FBrf0141768 for correction.

    (Roote et al., 1996)
    Synonyms and Secondary IDs (3)
    Reported As
    Symbol Synonym
    Df(2L)Adhfn2
    (O'Donnell et al., 1977)
    Df(2L)fn2
    Name Synonyms
    Deficiency (2L) formaldehyde induced
    Secondary FlyBase IDs
      References (21)