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FB2026_01
,
released March 12, 2026
b, black, Gad2, DGad2, BG:DS00941.5
Please see the JBrowse view of Dmel\Adc for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.41
Gene model reviewed during 5.45
Gene model reviewed during 5.51
2.3, 2.1 (northern blot)
514 (aa); 58 (kD)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Adc using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
b expression is observed in adults in the neuropil of the lamina and in regions of the thoracic musculature. Specifically, thoracic hybridization is seen to the tergotrochanteral muscle and in striations along the dorsal medial muscles. Faint hybridization was also observed in a small section of the ventral ganglion in larvae.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Adc in JBrowse2-49
2-45.1
2-48.5 +/- 0.2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Haploinsufficient locus (not associated with strong haplolethality or haplosterility).
Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day.
Isolation and characterisation of the second pyridoxal phosphate-dependent decarboxylase.
Transcript identified during molecular analysis of the Sos genomic region.
b has been molecularly characterised.
Black pigment on body and tarsi and along wing veins. Reflectance of cuticle 40% that of wild type (Pedersen, 1982). Heterozygote somewhat darker than wild type, especially on trident, but never confused with homozygote. Body color darker at low temperature (Sherald, 1981). Puparium lighter than wild type. Not easily classified in newly emerged flies (Waddington, 1942). Tyrosinase formed in adult flies (Horowitz). Fails to synthesize beta-alanine (Hodgetts, 1972) and feeding or injection of beta-alanine to b produces normal phenotype (Jacobs, 1974; Hodgetts, Hodgetts and Choi, 1974). Also corrected by feeding 6-azauracil (Pedersen, 1982); feeding 6-azathymine produces weak b phenocopy which is suppressed by Su(b) (Pedersen). ERG normal (Hotta and Benzer, 1969). Puparial case structurally abnormal with wide, diffuse, exocuticular lamellae and indistinct endocuticular fibrils (Jacobs, 1978). Pupae UV sensitive (Jacobs, 1978). Suppressed by su(b) (Sherald, 1981) and Su(b) (Pedersen); enhanced by sp2 (Gubb) and su(r) (Pedersen). su(r) su(b) b is enhanced black; su(r) b not enhanced by feeding 6-azauracil (Pedersen). Possibly structural gene for beta-ureidopropionase (Sherald).
Source for merge of: b Gad2 anon-34Db
Source for identity of: b CG7811
Source for identity of: Adc b
The original gene name "black" (b) was changed to "Acidic amino acid decarboxylase" (Adc) to reflect its activity and eliminate its potentially offensive association with human characteristics.
