FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term carbon-carbon lyase activity ID (Ontology) GO:0016830 (Gene Ontology)
Definition Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 carbon-carbon lyase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | carbon-carbon lyase activity       --
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  catalytic activity
   |__lyase activity
       |__carbon-carbon lyase activity  41 rec.
           |__2-iminoacetate synthase activity
           |__3,4-dihydroxy-2-butanone-4-phosphate synthase activity
           |__aldehyde oxygenase (deformylating) activity
           |__aldehyde-lyase activity 7 rec.
           |   |__(S)-hydroxynitrile lyase activity(+)
           |   |__2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity
           |   |__2-dehydro-3-deoxy-D-gluconate aldolase activity
           |   |__2-dehydro-3-deoxy-D-pentonate aldolase activity
           |   |__2-dehydro-3-deoxy-L-pentonate aldolase activity
           |   |__2-dehydro-3-deoxy-phosphogluconate aldolase activity
           |   |__2-dehydro-3-deoxyglucarate aldolase activity
           |   |__2-dehydropantoate aldolase activity
           |   |__2-hydroxyacyl-CoA lyase activity(+) 1 rec.
           |   |__2-keto-3-deoxy-L-rhamnonate aldolase activity
           |   |__3-deoxy-D-manno-octulosonate aldolase activity
           |   |__4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase activity
           |   |__4-hydroxy-2-ketopimelate aldolase activity
           |   |__4-hydroxy-L-threonine aldolase activity
           |   |__5-dehydro-2-deoxyphosphogluconate aldolase activity
           |   |__6-carboxytetrahydropterin synthase activity
           |   |__6-deoxy-6-sulfofructose-1-phosphate aldolase activity
           |   |__7,8-dihydromonapterin aldolase activity
           |   |__aliphatic (R)-hydroxynitrile lyase activity
           |   |__benzoin aldolase activity
           |   |__D-threonine aldolase activity
           |   |__deoxyribose-phosphate aldolase activity 1 rec.
           |   |__dihydroneopterin aldolase activity
           |   |__dimethylaniline-N-oxide aldolase activity
           |   |__feruloyl-CoA hydratase/lyase activity
           |   |__fructose 6-phosphate aldolase activity
           |   |__fructose-1-phosphate aldolase activity 1 rec.
           |   |__fructose-6-phosphate phosphoketolase activity
           |   |__fructose-bisphosphate aldolase activity 1 rec.
           |   |__fucosterol-epoxide lyase activity
           |   |__hexulose-6-phosphate synthase activity
           |   |__hydroxymandelonitrile lyase activity
           |   |__hydroxytrimethyllysine aldolase activity 2 rec.
           |   |__indole-3-glycerol-phosphate lyase activity
           |   |__ketotetrose-phosphate aldolase activity
           |   |__L-fuculose-phosphate aldolase activity
           |   |__lactate aldolase activity
           |   |__mandelonitrile lyase activity
           |   |__phenylserine aldolase activity
           |   |__phosphoketolase activity
           |   |__propioin synthase activity
           |   |__rhamnulose-1-phosphate aldolase activity
           |   |__sphinganine-1-phosphate aldolase activity 1 rec.
           |   |__tagatose-bisphosphate aldolase activity
           |   |__threonine aldolase activity(+) 1 rec.
           |   |__trans-o-hydroxybenzylidenepyruvate hydratase-aldolase activity
           |   |__trimethylamine-oxide aldolase activity
           |__benzylsuccinate synthase activity
           |__carboxy-lyase activity 24 rec.
           |   |__2,2-dialkylglycine decarboxylase (pyruvate) activity
           |   |__2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity
           |   |__2-oxoglutarate decarboxylase activity
           |   |__3,4-dihydroxyphenylacetaldehyde synthase activity 1 rec.
           |   |__3,4-dihydroxyphthalate decarboxylase activity
           |   |__3-dehydro-L-gulonate-6-phosphate decarboxylase activity
           |   |__3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase activity
           |   |__3-oxolaurate decarboxylase activity
           |   |__4,5-dihydroxyphthalate decarboxylase activity
           |   |__4-carboxymuconolactone decarboxylase activity
           |   |__4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity 1 rec.
           |   |__4-hydroxy-3-polyprenylbenzoate decarboxylase activity
           |   |__4-hydroxybenzoate decarboxylase activity
           |   |__4-hydroxyphenylacetate decarboxylase activity
           |   |__4-hydroxyphenylpyruvate decarboxylase activity
           |   |__4-oxalocrotonate decarboxylase activity
           |   |__5-guanidino-2-oxopentanoate decarboxylase activity
           |   |__5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity
           |   |__6-methylsalicylate decarboxylase activity
           |   |__acetoacetate decarboxylase activity
           |   |__acetolactate decarboxylase activity
           |   |__acetylenedicarboxylate decarboxylase activity
           |   |__aconitate decarboxylase activity
           |   |__adenosylmethionine decarboxylase activity 1 rec.
           |   |__aminobenzoate decarboxylase activity
           |   |__aminocarboxymuconate-semialdehyde decarboxylase activity
           |   |__arginine decarboxylase activity
           |   |__aromatic-L-amino-acid decarboxylase activity(+) 1 rec.
           |   |__arylmalonate decarboxylase activity
           |   |__aspartate 1-decarboxylase activity 1 rec.
           |   |__aspartate 4-decarboxylase activity
           |   |__benzoylformate decarboxylase activity
           |   |__branched-chain-2-oxoacid decarboxylase activity
           |   |__carnitine decarboxylase activity
           |   |__cytosylglucuronate decarboxylase activity
           |   |__D-dopachrome decarboxylase activity
           |   |__dehydro-L-gulonate decarboxylase activity
           |   |__diaminobutyrate decarboxylase activity
           |   |__diaminopimelate decarboxylase activity
           |   |__dihydrocamalexic acid decarboxylase activity
           |   |__dihydroxyfumarate decarboxylase activity
           |   |__diphosphomevalonate decarboxylase activity 1 rec.
           |   |__gallate decarboxylase activity
           |   |__gamma-glutamyl carboxylase activity 1 rec.
           |   |__gentisate decarboxylase activity
           |   |__glutamate decarboxylase activity 2 rec.
           |   |__histidine decarboxylase activity 1 rec.
           |   |__hydroxyglutamate decarboxylase activity
           |   |__hydroxypyruvate decarboxylase activity
           |   |__indole-3-glycerol-phosphate synthase activity
           |   |__indolepyruvate decarboxylase activity
           |   |__lysine decarboxylase activity
           |   |__malolactic enzyme activity
           |   |__malonyl-CoA decarboxylase activity
           |   |__methionine decarboxylase activity
           |   |__methyl/ethyl malonyl-CoA decarboxylase activity
           |   |__o-pyrocatechuate decarboxylase activity
           |   |__ornithine decarboxylase activity 2 rec.
           |   |__orotidine-5'-phosphate decarboxylase activity 1 rec.
           |   |__orsellinate decarboxylase activity
           |   |__oxalate decarboxylase activity
           |   |__oxaloacetate decarboxylase activity 1 rec.
           |   |__oxalyl-CoA decarboxylase activity
           |   |__pantothenoylcysteine decarboxylase activity
           |   |__phenyl-phosphate phosphatase/carboxylase activity
           |   |__phenylacetaldehyde synthase activity
           |   |__phenylalanine decarboxylase activity
           |   |__phenylpyruvate decarboxylase activity
           |   |__phosphatidylserine decarboxylase activity 1 rec.
           |   |__phosphoenolpyruvate carboxykinase activity(+) 2 rec.
           |   |__phosphomevalonate decarboxylase activity
           |   |__phosphonopyruvate decarboxylase activity
           |   |__phosphopantothenoylcysteine decarboxylase activity 1 rec.
           |   |__phosphoribosylaminoimidazole carboxylase activity 1 rec.
           |   |__protocatechuate decarboxylase activity
           |   |__pyrrole-2-carboxylate decarboxylase activity
           |   |__pyruvate decarboxylase activity
           |   |__ribulose-bisphosphate carboxylase activity
           |   |__serine decarboxylase activity
           |   |__stipitatonate decarboxylase activity
           |   |__sulfinoalanine decarboxylase activity 1 rec.
           |   |__sulfopyruvate decarboxylase activity
           |   |__tartrate decarboxylase activity
           |   |__tartronate-semialdehyde synthase activity
           |   |__threonine-phosphate decarboxylase activity
           |   |__tyrosine decarboxylase activity 2 rec.
           |   |__UDP-D-apiose synthase activity
           |   |__UDP-galacturonate decarboxylase activity
           |   |__UDP-glucuronate decarboxylase activity 1 rec.
           |   |__uracil-5-carboxylate decarboxylase activity
           |   |__uroporphyrinogen decarboxylase activity 1 rec.
           |   |__valine decarboxylase activity
           |__DNA photolyase activity 3 rec.
           |   |__deoxyribodipyrimidine photo-lyase activity 2 rec.
           |   |__DNA (6-4) photolyase activity
           |__GTP 3',8'-cyclase activity 1 rec.
           |__long-chain fatty aldehyde oxidative decarbonylase activity 2 rec.
           |__oxo-acid-lyase activity 1 rec.
           |   |__(1-hydroxycyclohexan-1-yl)acetyl-CoA lyase activity
           |   |__(3R)-citramalyl-CoA lyase activity
           |   |__(4S)-4-hydroxy-2-oxoglutarate aldolase activity
           |   |__(R,S)-4-hydroxy-2-oxoglutarate aldolase activity
           |   |__(S)-citramalyl-CoA lyase activity
           |   |__1,4-dihydroxy-2-naphthoyl-CoA synthase activity
           |   |__2,3-dimethylmalate lyase activity
           |   |__3-hydroxy-3-isohexenylglutaryl-CoA lyase activity
           |   |__3-hydroxyaspartate aldolase activity
           |   |__4-amino-4-deoxychorismate lyase activity
           |   |__4-hydroxy-2-oxovalerate aldolase activity
           |   |__4-hydroxy-4-methyl-2-oxoglutarate aldolase activity
           |   |__anthranilate synthase activity
           |   |__chorismate lyase activity
           |   |__citramalate lyase activity
           |   |__citrate (pro-3S)-lyase activity
           |   |__citryl-CoA lyase activity
           |   |__hydroxymethylglutaryl-CoA lyase activity 1 rec.
           |   |__isocitrate lyase activity
           |   |__L-erythro-3-methylmalyl-CoA lyase activity
           |   |__malyl-CoA lyase activity
           |   |__methylisocitrate lyase activity
           |   |__N-acetylneuraminate lyase activity
           |   |__oxalomalate lyase activity
           |   |__tRNA-4-demethylwyosine synthase activity
           |__phosphomethylpyrimidine synthase activity
           |__tryptophanase activity
           |__tyrosine phenol-lyase activity
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Synonyms
  • "other carbon-carbon lyase activity" NARROW
Secondary IDs
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EC:4.1.-.-
Reactome:R-HSA-189425 "UROD decarboxylates URO3 to COPRO3"
Reactome:R-HSA-190182 "UROD decarboxylates URO1 to COPRO1"
Reactome:R-HSA-389611 "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA"