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FB2021_03, released June 15, 2021

Gene: Dmel\l(2)34Fc

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General Information
Symbol
Dmel\l(2)34Fc
Species
D. melanogaster
Name
lethal (2) 34Fc
Annotation Symbol
CG7532
Feature Type
protein_coding_gene
FlyBase ID
FBgn0261534
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Summary
May have antimicrobial activity. A late response immune regulated gene that is negatively regulated by spz during the immune response. (UniProt, Q9V3Y3)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

l(2)br8, BG:DS01068.5 , DS01068.5

Key Links
Genomic Location
Cytogenetic map
35A1-35A2
Sequence location
2L:14,349,020..14,351,513 [-]
Recombination map
2-50
RefSeq locus
NT_033779 REGION:14349020..14351513
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (3 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in defense response to protozoan
inferred from mutant phenotype
(assigned by UniProt )
(De Gregorio et al., 2002)
involved_in negative regulation of immune response
inferred from mutant phenotype
(assigned by UniProt )
(De Gregorio et al., 2002)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in extracellular region
inferred from sequence or structural similarity with UniProtKB:Q0Q029
(assigned by UniProt )
(UniProt Curators, 2002-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the insect defense protein family. (Q9V3Y3)
Protein Signatures (InterPro)
Summaries
Protein Function (UniProtKB)
May have antimicrobial activity. A late response immune regulated gene that is negatively regulated by spz during the immune response.
(UniProt, Q9V3Y3)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\l(2)34Fc for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene
gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
l(2)34Fc-RA
FBtr0080640
NM_135866
656
159
l(2)34Fc-RB
FBtr0343680
NM_001299001
733
159
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
l(2)34Fc-PA
FBpp0080212
17.2
159
8.48
NP_609710
AAF53387
l(2)34Fc-PB
FBpp0310269
17.2
159
8.48
NP_001285930
AHN54444
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

159 aa isoforms: l(2)34Fc-PA, l(2)34Fc-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\l(2)34Fc using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\l(2)34Fc in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB
EMBL-EBI Single Cell Expression Atlas
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 14 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of l(2)34Fc
Transgenic constructs containing regulatory region of l(2)34Fc
Aberrations (Deficiencies and Duplications) ( 139 )
Inferred from experimentation ( 139 )
Gene not disrupted in
Df(2L)A48
(Roote et al., 1996, Fossett et al., 1994, Gubb et al., 1990, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A63
(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A72
(Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A178
(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A220
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A245
(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A260
(Ashburner et al., 1982)
Df(2L)A264
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A266
(Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A267
(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A379
(Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A400
(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A445
(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)Adh-nBR102
(Roote et al., 1996, Fossett et al., 1994)
Df(2L)Adh-nBR105
(Fossett et al., 1994)
Df(2L)Adh-nBR106
(Fossett et al., 1994)
Df(2L)Adh-nBR107
(Fossett et al., 1994)
Df(2L)Adh-nBR118
(Fossett et al., 1994)
Df(2L)Adh-nBR119
(Fossett et al., 1994)
Df(2L)Adh-nBR121
(Fossett et al., 1994)
Df(2L)Adh-nBR122
(Fossett et al., 1994)
Df(2L)Adh-nBR126
(Fossett et al., 1994)
Df(2L)Adh-nBR127
(Fossett et al., 1994)
Df(2L)Adh-nBR128
(Fossett et al., 1994)
Df(2L)Adh-nBR129
(Fossett et al., 1994)
Df(2L)ARR1
(Roote et al., 1996)
Df(2L)b75
(Gubb et al., 1990, Woodruff and Ashburner, 1979)
Df(2L)b78j
(Roote, 2009.11.24)
Df(2L)ED8185
(Roote, 2009.11.24, Roote, 2009.11.24)
Df(2L)ED8186
(Roote, 2009.11.24, Roote, 2009.11.24)
Df(2L)el14
(Roote et al., 1996)
Df(2L)fn2
(Roote et al., 1996, Ashburner et al., 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Df(2L)fn3
(Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Df(2L)fn15
(Ashburner et al., 1982, O'Donnell et al., 1977)
Df(2L)fn27
(Ashburner et al., 1982, Ashburner et al., 1982, O'Donnell et al., 1977)
Df(2L)k08712-rv21
(Roote, 2009.11.24)
Df(2L)k08712-rv34
(Roote, 2009.11.24)
Df(2L)n78l3
(Ashburner et al., 1982)
Df(2L)osp29
(Roote et al., 1996, Ashburner et al., 1982)
Df(2L)osp144
(Roote et al., 1996, Ashburner et al., 1982)
Df(2L)Scorv4
(Woodruff and Ashburner, 1979)
Df(2L)TE35B-1
(Gubb et al., 1985)
Df(2L)TE35B-6
(Gubb et al., 1985)
Df(2L)TE35B-7
(Roote et al., 1996, Gubb et al., 1985)
Df(2L)TE35B-11
(Roote et al., 1996, Gubb et al., 1985)
Df(2L)TE35B-12
(Roote et al., 1996, Gubb et al., 1985)
Df(2L)TE35B-54L
(Roote et al., 1996)
Df(2L)TE35BC-1
(Gubb et al., 1984)
Df(2L)TE35BC-3
(Gubb et al., 1984, Ashburner et al., 1982)
Df(2L)TE35BC-4
(Roote et al., 1996, Gubb et al., 1984, Ashburner et al., 1982)
Df(2L)TE35BC-7
(Gubb et al., 1984)
Df(2L)TE35BC-8
(Gubb et al., 1984)
Df(2L)TE35BC-24
(Gubb et al., 1984)
Df(2L)TE35BC-28
(Gubb et al., 1984)
Df(2L)TE35BC-34
(Gubb et al., 1984)
Df(2L)TE35BC-35
(Gubb et al., 1984)
Dp(2;2)Cam12
(Roote et al., 1996)
In(2L)TE35B-13
(Gubb et al., 1985)
In(2LR)el6LA379R
(Roote et al., 1996)
T(2;3)Scorv7
(Woodruff and Ashburner, 1979)
T(2;4)GT6
(Roote, 1999.6.8)
T(Y;2)A80DR15P
(Ashburner et al., 1982, Woodruff and Ashburner, 1979)
T(Y;2)J165DP58P
(Woodruff and Ashburner, 1979)
T(Y;2)R15DJ165P
(Woodruff and Ashburner, 1979)
Tp(2;2)A446
(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Ts(2Lt;3Lt)dpps19+Ts(2Rt;3Rt)el24
(Roote et al., 1996)
Ts(2Lt;3Lt)TE35B-28+Ts(2Rt;3Rt)osp90
(Roote et al., 1996)
Ts(2Lt;3Rt)GT10+Ts(2Rt;3Lt)TE35B-209
(Roote et al., 1996)
Ts(Y;2Lt)el4+Ts(YSt;2Rt)A80
(Roote et al., 1996)
Ts(Y;2Lt)el4+Ts(YSt;2Rt)R15
(Roote et al., 1996, Ashburner et al., 1982)
Ts(Y;2Lt)GT2+Ts(YSt;2Rt)A80
(Roote et al., 1996)
Gene not duplicated in
Dp(2;2)TE35B-54L
(Roote et al., 1996)
Dp(2;3)osp3
(Roote et al., 1996)
In(2L)C163.41LC158R
(Roote et al., 1996)
In(2LR)TE35B-226LDTD128R
(Roote et al., 1996)
Ts(Y;2Lt)TE35B-18+Ts(YSt;2Rt)A80
(Roote et al., 1996)
Ts(YLt;2Lt)A80+Ts(Y;2Rt)el4
(Roote et al., 1996)
Ts(YLt;2Lt)R15+Ts(Y;2Rt)el4
(Roote et al., 1996)
Ts(YLt;2Lt)R15+Ts(Y;2Rt)TE35B-18
(Roote et al., 1996)
Ts(YLt;2Lt)R15+Ts(YSt;2Rt)A80
(Roote et al., 1996)
Gene disrupted in
Df(2L)64j
(Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Df(2L)A47
(Roote et al., 1996, Fossett et al., 1994, Gubb et al., 1990, Ashburner et al., 1982)
Df(2L)A215
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A217
(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A246
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A263
(Ashburner et al., 1982)
Df(2L)A337
(Fossett et al., 1994)
Df(2L)A376
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A377
(Ashburner et al., 1982)
Df(2L)Adh-nBR100
(Fossett et al., 1994)
Df(2L)Adh-nBR101
(Fossett et al., 1994)
Df(2L)Adh-nBR103
(Fossett et al., 1994)
Df(2L)Adh-nBR117
(Fossett et al., 1994)
Df(2L)Adh-nBR120
(Fossett et al., 1994)
Df(2L)Adh-nBR125
(Fossett et al., 1994)
Df(2L)Adh-nBR130
(Fossett et al., 1994)
Df(2L)Adh-nBR131
(Fossett et al., 1994)
Df(2L)b80e3
(Roote et al., 1996, Ashburner et al., 1982)
Df(2L)b81a1
(Roote et al., 1996, Ashburner et al., 1982)
Df(2L)b83d29a
(Roote et al., 1996)
Df(2L)b84a2
(Roote et al., 1996)
Df(2L)b84a4
(Roote et al., 1996)
Df(2L)b88h49
(Roote et al., 1996)
Df(2L)do1
(Roote, 1996.8)
Df(2L)el77
(Woodruff and Ashburner, 1979)
Df(2L)EP(2)2039-rv4
(Roote, 2000.6.13)
Df(2L)Exel6035
(Ryder, 2004.4.26)
Df(2L)fn1
(Ashburner et al., 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Df(2L)fn5
(Ashburner et al., 1982, O'Donnell et al., 1977)
Df(2L)fn7
(Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Df(2L)fn12
(Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Df(2L)fn26
(Ashburner et al., 1982, O'Donnell et al., 1977)
Df(2L)fn30
(Ashburner et al., 1982, O'Donnell et al., 1977)
Df(2L)fn31
(Ashburner et al., 1982, O'Donnell et al., 1977)
Df(2L)fn36
(Ashburner et al., 1982, O'Donnell et al., 1977)
Df(2L)GT4
(Gubb et al., 1990)
Df(2L)GT5
(Gubb et al., 1990)
Df(2L)TE35B-2
(Gubb et al., 1985)
Df(2L)TE35B-3
(Gubb et al., 1985)
Df(2L)TE35B-4
(Gubb et al., 1985)
Df(2L)TE35B-5
(Gubb et al., 1985)
Df(2L)TE35B-8
(Roote et al., 1996, Gubb et al., 1985)
Df(2L)TE35B-9
(Gubb et al., 1985)
Df(2L)TE35B-10
(Gubb et al., 1985)
Df(2L)TE35B-15
(Gubb et al., 1985)
Df(2L)TE35B-300
(Roote et al., 1996)
Df(2L)TE35BC-6
(Gubb et al., 1984)
Df(2L)TE35BC-23
(Gubb et al., 1984)
Df(2L)TE35BC-29
(Gubb et al., 1984)
Df(2L)TE35BC-31
(Gubb et al., 1984)
Df(2L)W
(Ashburner et al., 1982, Woodruff and Ashburner, 1979)
In(2L)75cLC158.1R
(Woodruff and Ashburner, 1979)
In(2L)75c
(Woodruff and Ashburner, 1979)
In(2LR)D20Lnoc4R
(Roote et al., 1996)
T(2;3)GT10
(Ashburner et al., 1999.10.12, Gubb et al., 1990)
T(2;4)GT6
(Gubb et al., 1990)
Ts(2Lt;4Lt)GT6+Ts(2Rt;4Rt)TE35B-101
(Roote et al., 1996, Roote, 1995.3.27)
Gene duplicated in
Ts(2Lt;4Lt)TE35B-101+Ts(2Rt;4Rt)GT6
(Roote et al., 1996)
Ts(YLt;2Lt)A80+Ts(YLt;2Rt)G74
(Roote et al., 1996)
Gene partially disrupted in
Ts(2Lt;3Rt)GT10+Ts(2Rt;3Lt)TE35BC-8
(Ashburner et al., 1999.10.12)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | recessive
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\FRRS1
6 of 15
Yes
No
1  
Hsap\REELD1
2 of 15
No
No
Hsap\FRRS1L
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Frrs1
5 of 15
Yes
No
Mmus\Frrs1l
1 of 15
No
No
Rattus norvegicus (Norway rat) (2)
Rnor\Frrs1
3 of 13
Yes
No
Rnor\Frrs1l
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (5)
Xtro\frrs1
3 of 12
Yes
No
Xtro\LOC105947222
2 of 12
No
Yes
Xtro\frrs1l
1 of 12
No
No
Xtro\LOC100489839
1 of 12
No
No
Xtro\LOC100491943
1 of 12
No
No
Danio rerio (Zebrafish) (9)
Drer\si:dkey-251i10.2
9 of 15
Yes
Yes
Drer\si:ch73-14h1.2
4 of 15
No
Yes
Drer\frrs1a
3 of 15
No
No
Drer\frrs1b
3 of 15
No
No
Drer\zgc:163022
3 of 15
No
No
Drer\si:ch73-196i15.3
2 of 15
No
Yes
Drer\frrs1l
1 of 15
No
No
Drer\LOC108179094
1 of 15
No
Yes
Drer\si:ch73-196i15.5
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (7)
Cele\C05D12.1
5 of 15
Yes
No
Cele\C13B4.1
3 of 15
No
No
Cele\M03A1.3
3 of 15
No
No
Cele\F23B12.4
2 of 15
No
Yes
Cele\M03A1.8
2 of 15
No
No
Cele\C44B7.5
1 of 15
No
No
Cele\Y57G11A.4
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190H4E )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00000879
Drosophila simulans
Dsim\GD22011
Drosophila sechellia
Dsec\GM14866
Drosophila erecta
Dere\GG10152
Drosophila yakuba
Dyak\GE25048
Drosophila ananassae
Dana\GF14493
Drosophila pseudoobscura pseudoobscura
Dpse\GA20419
Drosophila persimilis
Dper\GL21051
Drosophila willistoni
Dwil\GK18114
Drosophila virilis
Dvir\GJ18058
Drosophila mojavensis
Dmoj\GI17382
Drosophila grimshawi
Dgri\GH10402
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150ED3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17013052
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_02566
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_11086
Anopheles darlingi
American malaria mosquito
Adar\ADAC010239
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0HR0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ixodes scapularis
Black-legged tick
Isca\ISCW005667
Ixodes scapularis
Black-legged tick
Isca\ISCW003629
Ixodes scapularis
Black-legged tick
Isca\ISCW000006
Ixodes scapularis
Black-legged tick
Isca\ISCW000233
Ixodes scapularis
Black-legged tick
Isca\ISCW017732
Ixodes scapularis
Black-legged tick
Isca\ISCW017733
Ixodes scapularis
Black-legged tick
Isca\ISCW018240
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g09320
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (2)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG8399
5 of 10
CG14515
3 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    FRRS1; ferric chelate reductase 1
    6 of 15
    611578
         
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Interactions Browser
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2L
        Recombination map
        2-50
        Cytogenetic map
        35A1-35A2
        Sequence location
        2L:14,349,020..14,351,513 [-]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        35A1-35A2
        Left limit from complementation mapping against In(2L)75c (FBrf0033164) Right limit from complementation mapping against T(Y;2)el4 (FBrf0091422)
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        2-50

        (FlyBase, 2016)

        2-46.2

        (Comeron et al., 2012)

        2-[49]

        Left of (cM)
        (Woodruff and Ashburner, 1979)
        Right of (cM)
        Notes

        Excisions of Rab14k08712 show that the gene order is ms(2)34Fe, l(2)34Fd, Rab14, Pgant35A.

        (Ashburner et al., 1999.10.12)

        Maps 0.19cM to the left of Tp(2;2)Sco.

        (Woodruff and Ashburner, 1979)
        Stocks and Reagents
        Stocks (8)
        Genomic Clones (17)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (24)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of

        Source for identity of: BG:DS01068.5 CG7532

        (Kodira, 1999.11)
        Source for database merge of

        Source for merge of: BG:DS01068.5 anon- EST:ParkEST060

        (Bayraktaroglu, 2000.11.2)

        Source for merge of: l(2)34Fc CG7532

        (Roote, 2009.11.24)

        Source for merge of: CG7532 BcDNA:RE60882

        (FlyBase, 1996-)
        Additional comments

        " BG:DS01068.1 ", " BG:DS01068.2 ", " BG:DS01068.10 ", " BG:DS01068.4 ", " BG:DS01068.5 " or " BG:DS01068.11 " may correspond to "l(2)34Fc".

        (Ashburner et al., 1999.10.12)

        " BG:DS01068.5 " may correspond to "ms(2)34Fe", "l(2)34Fc" or "l(2)34Fd".

        (Ashburner et al., 1999.10.12)

        Source for merge of CG7532 BcDNA:RE60882 was a shared cDNA ( date:030728 ).

        (FlyBase, 1996-)
        Other Comments
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 32 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DRscDB
        EMBL-EBI Single Cell Expression Atlas
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        FlyMine - An integrated database for Drosophila genomics
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL
        modMine - A data warehouse for the modENCODE project
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        Synonyms and Secondary IDs (13)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (59)